Marburg hemorrhagic fever natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

If left untreated symptoms of marburg hemorrhagic fever become increasingly severe and can include jaundice, inflammation of the pancreas, severe weight loss, delirium, shock, liver failure, massive hemorrhage, and multi-organ dysfunction. Common complications of marburg hemorrhagic fever include orchitis, Transverse myelitis and Parotitis. Prognosis of marburg hemorrhagic fever is generally poor. Case fatality rates in marburg hemorrhagic fever outbreaks have ranged from 23% to 90%.

Natural History

Complications

Common complications of marburg hemorrhagic fever include:[2][3]

Prognosis

References

  1. Grolla A, Lucht A, Dick D, Strong JE, Feldmann H (2005). "Laboratory diagnosis of Ebola and Marburg hemorrhagic fever". Bull Soc Pathol Exot. 98 (3): 205–9. PMID 16267962.
  2. Bausch DG, Borchert M, Grein T, Roth C, Swanepoel R, Libande ML, Talarmin A, Bertherat E, Muyembe-Tamfum JJ, Tugume B, Colebunders R, Kondé KM, Pirad P, Olinda LL, Rodier GR, Campbell P, Tomori O, Ksiazek TG, Rollin PE (2003). "Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo". Emerging Infect. Dis. 9 (12): 1531–7. doi:10.3201/eid0912.030355. PMC 3034318. PMID 14720391.
  3. Roddy P, Thomas SL, Jeffs B, Nascimento Folo P, Pablo Palma P, Moco Henrique B, Villa L, Damiao Machado FP, Bernal O, Jones SM, Strong JE, Feldmann H, Borchert M (2010). "Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola". J. Infect. Dis. 201 (12): 1909–18. doi:10.1086/652748. PMC 3407405. PMID 20441515.
  4. Smith CE, Simpson DI, Bowen ET, Zlotnik I (1967). "Fatal human disease from vervet monkeys". Lancet. 2 (7526): 1119–21. PMID 4168558.
  5. Kissling RE, Robinson RQ, Murphy FA, Whitfield SG (1968). "Agent of disease contracted from green monkeys". Science. 160 (3830): 888–90. PMID 4296724.