U3 small nucleolar ribonucleoprotein protein MPP10 is a protein that in humans is encoded by the MPHOSPH10 gene .[1] [2] [3]
This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing.[3]
References
↑ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning" . Mol Biol Cell . 7 (9): 1455–69. doi :10.1091/mbc.7.9.1455 . PMC 275994 PMID 8885239 . ↑ Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ (Mar 1998). "M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component" . Mol Biol Cell . 9 (2): 437–49. doi :10.1091/mbc.9.2.437 . PMC 25272 PMID 9450966 . ↑ 3.0 3.1 "Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)" .
Further reading
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol . 12 (1): 1–11. doi :10.1016/S0960-9822(01)00650-9 . PMID 11790298 . Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus" . Mol. Biol. Cell . 13 (11): 4100–9. doi :10.1091/mbc.E02-05-0271 . PMC 133617 PMID 12429849 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes" . Nucleic Acids Res . 31 (7): 1877–87. doi :10.1093/nar/gkg300 . PMC 152815 PMID 12655004 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. doi :10.1038/nature03207 . PMID 15635413 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 .
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