Lopressor injection/adult indications and dosage

Lopressor injection/adult indications and dosage®
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

FDA-Labeled Indications and Dosage (Adult)

Myocardial Infarction

• Upon patient presentation:

Lopressor injection 5 mg IV x 3 boluses at 2-min intervals

• 15 minutes after the full IV dose:

Lopressor tablet 50 mg PO q6h for 2 days followed by Lopressor tablet 100 mg PO q12h

or Lopressor tablet 25—50 mg PO q6h for 2 days if intolerable to the full IV dose; discontinue Lopressor in patients with severe intolerance.

Lopressor injection is indicated in the treatment of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality when used in conjunction with oral Lopressor maintenance therapy. Treatment with Lopressor injection can be initiated as soon as the patient’s clinical condition allows.

Early Treatment: During the early phase of definite or suspected acute myocardial infarction, initiate treatment with Lopressor injection as soon as possible after the patient’s arrival in the hospital. Such treatment should be initiated in a coronary care or similar unit immediately after the patient’s hemodynamic condition has stabilized. Begin treatment in this early phase with the intravenous administration of three bolus injections of 5 mg of Lopressor injection each; give the injections at approximately 2-minute intervals. During the intravenous administration of Lopressor, monitor blood pressure, heart rate, and electrocardiogram.

In patients who tolerate the full intravenous dose (15 mg), initiate Lopressor tablets, 50 mg every 6 hours, 15 minutes after the last intravenous dose and continue for 48 hours. Thereafter, the maintenance dosage is 100 mg orally twice daily. Start patients who appear not to tolerate the full intravenous dose on Lopressor tablets either 25 mg or 50 mg every 6 hours (depending on the degree of intolerance) 15 minutes after the last intravenous dose or as soon as their clinical condition allows. In patients with severe intolerance, discontinue Lopressor (see Warnings).

Off-Label Use and Dosage (Adult)

Cardiac Dysrhythmia

Lopressor injection (range: 2—15 mg) has been shown to be effective in the treatment of atrial flutter, atrial fibrillation, multifocal atrial tachycardia, and supraventricular tachycardia.

Injection Site Pain Associated with Propofol

Pretreatment with Lopressor injection (2 mg IV) was shown to be equally as effective as lidocaine in reducing the pain associated with propofol injection.