Levo-transposition of the great arteries epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [5]

Overview

Among patients with congenital heart disease, CCTGA has an incidence of 0.5%, with a slight male predominance.

Epidemiology and Demographics

• Among patients with congenital heart disease, CCTGA has an incidence of 0.5%, with a slight male predominance. 95% of CCTGA occurs in "situs solitus".
• Transposition of the great arteries TGA is one of the most common cyanotic congenital heart defects present in the first 24 hours of life.
• TGA represents 5-7% of all CHD with an incidence at birth of 20-30 in 100000 live births and almost 20 percent of all cyanotic CHD defects
• TGA is more common in infants of diabetic mothers.
• Boys outnumber girls with an approximate ratio of 2:1.
• Without treatment, 30% of infants die within the first week of life, 50% will die in the first month, 70% will die in the first 6 months and 90% of infants will die before the end of the first year.
• Heart defects are the most common birth defect, occurring in approximately 1% of live births
• Approximately one million people worldwide are currently living with a CHD
• Having a child with a CHD increases an individual’s chances of having another child with a CHD from 1% to 3%. Subsequent children born with a CHD increase that individual’s chances further.