Left bundle branch block epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2] ; J. Adrian Gutierrez [3]

Overview

LBBB is uncommon among patients under 50 years of age (<0.5%). It occurs in 6% to 8% of patients over the age of 50.

Epidemiology and Demographics

Prevalence

Prevalence of LBBB in the general population ranges from 200 to 1100 per 100,000. ^[1]

Age

Prevalence of LBBB increases with age. Large prospective studies have reported a mean age at diagnosis of approximately 70 years in men and 68 years in women. ^[2]

Prevalence in heart failure populations

Among patients with heart failure with reduced ejection fraction (HFrEF), LBBB is a common conduction abnormality. In an analysis of the PARADIGM-HF and ATMOSPHERE trials, LBBB was present in 15.1% of 11,861 patients. ^[3]

References

↑ Chung MK, Patton KK, Lau CP, Dal Forno AR, Al-Khatib SM, Arora V, Birgersdotter-Green UM, Cha YM, Chung EH, Cronin EM, Curtis AB, Cygankiewicz I, Dandamudi G, Dubin AM, Ensch DP, Glotzer TV, Gold MR, Goldberger ZD, Gopinathannair R, Gorodeski EZ, Gutierrez A, Guzman JC, Huang W, Imrey PB, Indik JH, Karim S, Karpawich PP, Khaykin Y, Kiehl EL, Kron J, Kutyifa V, Link MS, Marine JE, Mullens W, Park SJ, Parkash R, Patete MF, Pathak RK, Perona CA, Rickard J, Schoenfeld MH, Seow SC, Shen WK, Shoda M, Singh JP, Slotwiner DJ, Sridhar AR, Srivatsa UN, Stecker EC, Tanawuttiwat T, Tang WH, Tapias CA, Tracy CM, Upadhyay GA, Varma N, Vernooy K, Vijayaraman P, Worsnick SA, Zareba W, Zeitler EP (September 2023). "2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure". Heart Rhythm. 20 (9): e17–e91. doi:10.1016/j.hrthm.2023.03.1538. PMID 37283271 Check |pmid= value (help).
↑ Thein AS, Dixit S, Soliman EZ, Heckbert SR, Psaty BM, Gottdiener J, Marcus GM (August 2025). "Left Bundle Branch Block as a Risk Factor for Heart Failure". JAMA Netw Open. 8 (8): e2525801. doi:10.1001/jamanetworkopen.2025.25801. PMID 40773196 Check |pmid= value (help).
↑ Kristensen SL, Castagno D, Shen L, Jhund PS, Docherty KF, Rørth R, Abraham WT, Desai AS, Dickstein K, Rouleau JL, Zile MR, Swedberg K, Packer M, Solomon SD, Køber L, McMurray JJ (December 2020). "Prevalence and incidence of intra-ventricular conduction delays and outcomes in patients with heart failure and reduced ejection fraction: insights from PARADIGM-HF and ATMOSPHERE". Eur J Heart Fail. 22 (12): 2370–2379. doi:10.1002/ejhf.1972. PMID 32720404 Check |pmid= value (help).

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[pmid37283271-1] Chung MK, Patton KK, Lau CP, Dal Forno AR, Al-Khatib SM, Arora V, Birgersdotter-Green UM, Cha YM, Chung EH, Cronin EM, Curtis AB, Cygankiewicz I, Dandamudi G, Dubin AM, Ensch DP, Glotzer TV, Gold MR, Goldberger ZD, Gopinathannair R, Gorodeski EZ, Gutierrez A, Guzman JC, Huang W, Imrey PB, Indik JH, Karim S, Karpawich PP, Khaykin Y, Kiehl EL, Kron J, Kutyifa V, Link MS, Marine JE, Mullens W, Park SJ, Parkash R, Patete MF, Pathak RK, Perona CA, Rickard J, Schoenfeld MH, Seow SC, Shen WK, Shoda M, Singh JP, Slotwiner DJ, Sridhar AR, Srivatsa UN, Stecker EC, Tanawuttiwat T, Tang WH, Tapias CA, Tracy CM, Upadhyay GA, Varma N, Vernooy K, Vijayaraman P, Worsnick SA, Zareba W, Zeitler EP (September 2023). "2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure". Heart Rhythm. 20 (9): e17–e91. doi:10.1016/j.hrthm.2023.03.1538. PMID 37283271 Check |pmid= value (help).

[pmid40773196-2] Thein AS, Dixit S, Soliman EZ, Heckbert SR, Psaty BM, Gottdiener J, Marcus GM (August 2025). "Left Bundle Branch Block as a Risk Factor for Heart Failure". JAMA Netw Open. 8 (8): e2525801. doi:10.1001/jamanetworkopen.2025.25801. PMID 40773196 Check |pmid= value (help).

[pmid32720404-3] Kristensen SL, Castagno D, Shen L, Jhund PS, Docherty KF, Rørth R, Abraham WT, Desai AS, Dickstein K, Rouleau JL, Zile MR, Swedberg K, Packer M, Solomon SD, Køber L, McMurray JJ (December 2020). "Prevalence and incidence of intra-ventricular conduction delays and outcomes in patients with heart failure and reduced ejection fraction: insights from PARADIGM-HF and ATMOSPHERE". Eur J Heart Fail. 22 (12): 2370–2379. doi:10.1002/ejhf.1972. PMID 32720404 Check |pmid= value (help).

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