Leucine rich repeat containing 16A is a protein that in humans is encoded by the LRRC16A gene .[ 1] [ 1]
Model organisms
Model organisms have been used in the study of LRRC16A function. A conditional knockout mouse line, called Lrrc16atm1a(KOMP)Wtsi [ 6] [ 7] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[ 8] [ 9] [ 10]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[ 4] [ 11] mutant mice but no significant abnormalities were observed.[ 4]
References
↑ 1.0 1.1 "leucine rich repeat containing 16A" . Retrieved 2011-12-04 .↑ "Salmonella infection data for Lrrc16a" . Wellcome Trust Sanger Institute.↑ "Citrobacter infection data for Lrrc16a" . Wellcome Trust Sanger Institute.↑ 4.0 4.1 4.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . ↑ Mouse Resources Portal , Wellcome Trust Sanger Institute.↑ "International Knockout Mouse Consortium" .↑ "Mouse Genome Informatics" .↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature . 474 (7351): 262–3. doi :10.1038/474262a . PMID 21677718 . ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
Further reading
Yang, C.; Pring, M.; Wear, M. A.; Huang, M.; Cooper, J. A.; Svitkina, T. M.; Zigmond, S. H. (2005). "Mammalian CARMIL Inhibits Actin Filament Capping by Capping Protein" . Developmental Cell . 9 (2): 209–221. doi :10.1016/j.devcel.2005.06.008 . PMC 2628720 PMID 16054028 . Liang, Y.; Niederstrasser, H.; Edwards, M.; Jackson, C. E.; Cooper, J. A. (2009). "Distinct Roles for CARMIL Isoforms in Cell Migration" . Molecular Biology of the Cell . 20 (24): 5290–5305. doi :10.1091/mbc.E08-10-1071 . PMC 2793302 PMID 19846667 . Gunjaca, G.; Boban, M.; Pehlić, M.; Zemunik, T.; Budimir, D.; Kolcić, I.; Lauc, G.; Rudan, I.; Polasek, O. (2010). "Predictive Value of 8 Genetic Loci for Serum Uric Acid Concentration" . Croatian medical journal . 51 (1): 23–31. doi :10.3325/cmj.2010.51.23 . PMC 2829178 PMID 20162742 .
