Intussusception risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]


Common risk factors for the development of intussusception include male gender, age 6 to 12 months and anatomical anomaly of the intestine. Less common risk factors in the development of intussusception include antecedent viral illness, seasonal variation, first generation Rotavirus vaccine, Meckel's diverticulum, Celiac disease, polyp, cystic fibrosis, Henoch-Schönlein purpura (HSP), surgical procedures involving the gut, duplication cyst, lymphomas, and areas of reactive lymphoid hyperplasia.

Risk Factors

Common risk factors

  • Common risk factors in the development of intussusception include:
    • Male gender: It affects boys four times as often as girls
    • Age 6 to 12 months : Intussusception can affect both children and adults, although most cases occur in children ages 6 months to 2 years
    • Anatomic variation of the intestine

Less common risk factors


  1. Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, Barnett P, Bishop RF, Robins-Browne R, Carlin JB (2006). "Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus". J. Pediatr. 149 (4): 452–60. doi:10.1016/j.jpeds.2006.04.010. PMID 17011313.
  2. Nylund CM, Denson LA, Noel JM (2010). "Bacterial enteritis as a risk factor for childhood intussusception: a retrospective cohort study". J. Pediatr. 156 (5): 761–5. doi:10.1016/j.jpeds.2009.11.026. PMID 20138300.
  3. Buettcher M, Baer G, Bonhoeffer J, Schaad UB, Heininger U (2007). "Three-year surveillance of intussusception in children in Switzerland". Pediatrics. 120 (3): 473–80. doi:10.1542/peds.2007-0035. PMID 17766518.
  4. Shimabukuro TT, Nguyen M, Martin D, DeStefano F (2015). "Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS)". Vaccine. 33 (36): 4398–405. doi:10.1016/j.vaccine.2015.07.035. PMC 4632204. PMID 26209838.
  5. Mushtaq N, Marven S, Walker J, Puntis JW, Rudolf M, Stringer MD (1999). "Small bowel intussusception in celiac disease". J. Pediatr. Surg. 34 (12): 1833–5. PMID 10626866.
  6. Martinez G, Israel NR, White JJ (2001). "Celiac disease presenting as entero-enteral intussusception". Pediatr. Surg. Int. 17 (1): 68–70. doi:10.1007/s003830000395. PMID 11294274.
  7. Ludvigsson JF, Nordenskjöld A, Murray JA, Olén O (2013). "A large nationwide population-based case-control study of the association between intussusception and later celiac disease". BMC Gastroenterol. 13: 89. doi:10.1186/1471-230X-13-89. PMC 3661363. PMID 23679928.
  8. Ludvigsson JF, Nordenskjöld A, Murray JA, Olén O (2013). "A large nationwide population-based case-control study of the association between intussusception and later celiac disease". BMC Gastroenterol. 13: 89. doi:10.1186/1471-230X-13-89. PMC 3661363. PMID 23679928.
  9. Webb AK, Khan A (1989). "Chronic intussusception in a young adult with cystic fibrosis". J R Soc Med. 82 Suppl 16: 47–8. PMC 1291920. PMID 2657054.
  10. Gross K, Desanto A, Grosfeld JL, West KW, Eigen H (1985). "Intra-abdominal complications of cystic fibrosis". J. Pediatr. Surg. 20 (4): 431–5. PMID 4045671.
  11. Ebert EC (2008). "Gastrointestinal manifestations of Henoch-Schonlein Purpura". Dig. Dis. Sci. 53 (8): 2011–9. doi:10.1007/s10620-007-0147-0. PMID 18351468.
  12. Little KJ, Danzl DF (1991). "Intussusception associated with Henoch-Schonlein purpura". J Emerg Med. 9 Suppl 1: 29–32. PMID 1955678.
  13. López-Tomassetti Fernández EM, Lorenzo Rocha N, Arteaga González I, Carrillo Pallarés A (2006). "Ileoileal intussusception as initial manifestation of Crohn's disease". Mcgill J Med. 9 (1): 34–7. PMC 2687895. PMID 19529808.
  14. Cohen DM, Conard FU, Treem WR, Hyams JS (1992). "Jejunojejunal intussusception in Crohn's disease". J. Pediatr. Gastroenterol. Nutr. 14 (1): 101–3. PMID 1573498.
  15. Ein SH, Ferguson JM (1982). "Intussusception--the forgotten postoperative obstruction". Arch. Dis. Child. 57 (10): 788–90. PMC 1627910. PMID 7138069.
  16. Linke F, Eble F, Berger S (1998). "Postoperative intussusception in childhood". Pediatr. Surg. Int. 14 (3): 175–7. doi:10.1007/s003830050479. PMID 9880741.
  17. Kidd J, Jackson R, Wagner CW, Smith SD (2000). "Intussusception following the Ladd procedure". Arch Surg. 135 (6): 713–5. PMID 10843370.
  18. Klein JD, Turner CG, Kamran SC, Yu AY, Ferrari L, Zurakowski D, Fauza DO (2013). "Pediatric postoperative intussusception in the minimally invasive surgery era: a 13-year, single center experience". J. Am. Coll. Surg. 216 (6): 1089–93. doi:10.1016/j.jamcollsurg.2013.01.059. PMID 23571141.

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