Interstitial nephritis diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Mohsen Basiri M.D.
Overview
Renal biopsy is the gold standard and definitive test of establishing the diagnosis of AIN, however it is not needed in all patients and often considered to make a definitive diagnosis for patients who do not improve following withdrawal of offensive agent or in the presence of doubtful findings.
Diagnostic Study of Choice
Study of choice
- Renal biopsy is the gold standard test for the diagnosis of AIN. However, it is not needed in all patients, such as among patients with onset of renal failure after initiation of a common culprit drug and who improve immediately upon cessation the causative drug.[1]
The Renal biopsy should be performed when:
- Patients who do not improve following cessation of culprit drug
- Characteristic urinalysis for AIN, but there are not being treated with a drug known to cause AIN.
- Patients who are being considered for treatment with glucocorticoids for AIN
- Patients who present with advanced renal failure, providing the onset of renal failure is known to be relatively recent
References
- ↑ Baker, R. J.; Pusey, C. D. (2004). "The changing profile of acute tubulointerstitial nephritis". Nephrology Dialysis Transplantation. 19 (1): 8–11. doi:10.1093/ndt/gfg464. ISSN 0931-0509.