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Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.


Hypomelanosis is also referred to as hypopigmentation, and a condition in which there is too little pigment in the skin, hair, mucous membranes, and retina of the eye.


Common Causes

Causes by Organ System

Cardiovascular Varicosis
Chemical/Poisoning Azelaic acid
Dental No underlying causes
Dermatologic Actinic granuloma, Albinism, Albinoidism, Anemia, Anetoderma, Burns, Chediak-higashi disease, Cole disease, Dermatomyositis, Dyskeratosis congenita, Elejalde syndrome, Griscelli syndrome , Idiopathic guttate hypomelanosis, Incontinentia pigmenti, Ito syndrome, Lepromatous leprosy, Leprosy , Lymphoproliferative diseases, Malassezia furfur, Malignant melanoma, Melanocortin 1 receptor mutations, Melanoma, Neuroectodermal melanolysosomal disease, Nevus anemicus, Nevus depigmentosus, Oculo-cutaneous albinism, Pinta, Poikiloderma, Proopiomelanocortin deficiency, Psoriasis, Reticulate acropigmentation of dohi, Rothmund-thomson syndrome, Skin damage, Tinea versicolor, Transient bullous dermolysis of the newborn, Tuberculoid leprosy, Vitiligo
Drug Side Effect Corticosteroid injection, Drugs, Hydroquinone, Mequinol, Pazopanib
Ear Nose Throat No underlying causes
Endocrine Addison's disease, Albinism, Albinoidism, Chediak-higashi disease, Hashimoto's thyroiditis, Homocystinuria, Hyperthyroidism, Hypoparathyroidism, Hypothyroidism, Kwashiorkor, Marasmus, Nephropathic early-onset cystinosis, Phenylketonuria , Pituitary insufficiency, Polyendocrine deficiency syndrome type 2, Proopiomelanocortin deficiency
Environmental No underlying causes
Gastroenterologic Gastric carcinoma, Hirschsprung disease, Kwashiorkor, Marasmus
Genetic Angelman syndrome, Cole disease, Cowden's syndrome , Cross-mckusick-breen syndrome, Genetic defects, Hirschsprung disease, Melanocortin 1 receptor mutations, Menkes disease, Piebaldism, Polyendocrine deficiency syndrome type 2, Rothmund-thomson syndrome, Spondylometaphyseal dysplasia with combined immunodeficiency , Tietz syndrome, Transient bullous dermolysis of the newborn, Trichorhinophalangeal syndrome type i , Triploid syndrome, Vogt-koyanagi-harada syndrome, Waardenburg syndrome, Whitaker syndrome 
Hematologic Diabetes mellitus, Dysgammaglobulinemia, Lymphoproliferative diseases, Pernicious anemia, Thrombopenia
Iatrogenic Corticosteroid injection
Infectious Disease Candidiasis , Infection, Inflammation, Malassezia furfur, Onchocerciasis, Pinta, Pityriasis alba, Pseudoatrophoderma colli, Secondary syphilis, Tinea versicolor, Tuberculoid leprosy
Musculoskeletal/Orthopedic No underlying causes
Neurologic Angelman syndrome, Deafness, Phenylketonuria , Syringomyelia, Tuberous sclerosis, Yemenite deaf-blind hypopigmentation syndrome
Nutritional/Metabolic Diabetes mellitus
Obstetric/Gynecologic Candidiasis
Oncologic Cowden's syndrome , Cutaneous t-cell lymphoma, Dermatomyositis, Gastric carcinoma, Malignant melanoma, Melanoma
Ophthalmologic Homocystinuria, Oculo-cutaneous albinism
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Sarcoidosis
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Dysgammaglobulinemia, Juvenile rheumatoid arthritis , Myasthenia gravis, Psoriasis, Rheumatoid arthritis, Sarcoidosis, Scleroderma, Systemic lupus erythematosus
Sexual Secondary syphilis
Trauma Burns
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order[1] [2]


  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

See Also

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