Hereditary nonpolyposis colorectal cancer secondary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
Secondary prevention strategies following hereditary nonpolyposis colorectal cancer include genetic testing, colonoscopy, urine cytology, pelvic exam, and endometrial biopsy.
Secondary prevention
Secondary prevention strategies following hereditary nonpolyposis colorectal cancer include:[1][2][3]
- Colonoscopic screening every 2 years from the age of 25 - 35
- Annual Pelvic exam, transvaginal ultrasound and CA-125 level testing from the age of 25 - 35
- Endometrial biopsy (if warranted clinical symptoms)
- Annual Urine cytology from the age of 25 - 35 (for patients who have a family member diagnosed with transitional cell carcinoma of the ureter or renal pelvis)
References
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.
- ↑ Lynch HT, Lynch PM, Lanspa SJ, Snyder CL, Lynch JF, Boland CR (2009). "Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications". Clin Genet. 76 (1): 1–18. doi:10.1111/j.1399-0004.2009.01230.x. PMC 2846640. PMID 19659756.
- ↑ Vasen HF, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G; et al. (1996). "Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis". Gastroenterology. 110 (4): 1020–7. PMID 8612988.