Hereditary elliptocytosis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Niyousha Danesh M.D., M.P.H

Overview

Medical Therapy

  • Management of hereditary elliptocytosis includes supportive therapy.
  • The vast majority of patients being diagnosed with hereditary elliptocytosis do not need any medication.
  • However HE patients with sever anemia may require blood transfusions.
  • Phototherapy may be required in new borns with jaundice, specially in HPP and  Neonatal poikilocytosis subtypes of HE.
  • There exists no definite treatment for membrane defect in HE.
  • Moreover these patients may have folate deficiency due to hemolysis, so folic acid supplementation or folic acid rich diet(green leafy vegetables) is advised.
  • Folate helps to reduce the extent of hemolysis in those with significant hemolysis due to hereditary elliptocytosis.[1]

References

  1. Barcellini W, Bianchi P, Fermo E, Imperiali FG, Marcello AP, Vercellati C; et al. (2011). "Hereditary red cell membrane defects: diagnostic and clinical aspects". Blood Transfus. 9 (3): 274–7. doi:10.2450/2011.0086-10. PMC 3136593. PMID 21251470.

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