Hepatitis laboratory findings

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Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

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Laboratory Findings

• Hepatitis typically causes a rise in liver function tests. In particular, there is often a disproportionate rise in transaminases relative to the alkaline phosphatase, but this is not universal and the pattern can be suggestive of cause. Furthermore, primary sclerosing cholangitis can sometimes overlap with autoimmune hepatitis.

Immunology

This tends to be most useful when by exclusion autoimmune hepatitis is being considered and the following are necessary as components of a validated probability score.

• Autoantibodies
  • Antinuclear
  • Anti-smooth-muscle
  • Microsome type 1
  • Soluble liver antigen
• Serum IgG