Follicular lymphoma classification
|
Follicular lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Follicular lymphoma classification On the Web |
|
American Roentgen Ray Society Images of Follicular lymphoma classification |
|
Risk calculators and risk factors for Follicular lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
According to the World Health Organization (WHO), follicular lymphoma may be classified into 3 subtypes: low-grade follicular lymphoma, high-grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include pediatric follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma.
Classification
1- Morphological Classification
The World Health Organization (WHO) classifies follicular lymphoma as follows:[1][2]
- Grades 1 and 2 also known as low-grade follicular lymphoma
- Grade 3A as high-grade follicular lymphoma
- Grade 3B as diffuse large B cell lymphoma
2- Variants of Follicular Lymphoma
Follicular lymphoma has 3 variants that include the following:[3][4]
A. Pediatric follicular lymphoma
- Involves cervical lymph nodes, other peripheral lymph nodes, or Waldeyer's ring
- Patients typically have early-stage disease
- Lacks bcl-2 protein expression and t(14;18)
B. Primary intestinal follicular lymphoma
- Occurs most commonly in the small intestine, and frequently involves the duodenum.
- Duodenal follicular lymphoma
C. Other extranodal follicular lymphomas
- Usually have localized extranodal disease.
- Systemic relapses are rare.
- Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults.
References
- ↑ "Follicular Lymphomas". Retrieved 2008-07-26.
- ↑ Anderson T, Chabner BA, Young RC, Berard CW, Garvin AJ, Simon RM; et al. (1982). "Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute". Cancer. 50 (12): 2699–707. PMID 7139563.
- ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov
- ↑ Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y; et al. (2006). "Histological variety of floral variant of follicular lymphoma". APMIS. 114 (9): 626–32. doi:10.1111/j.1600-0463.2006.apm_424.x. PMID 16948815.