Flumetasone

Flumetasone

Clinical data
Synonyms	(6S,8S,9S,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical
ATC code	D07AB03 (WHO) , D07XB01 (WHO) (combinations), Template:ATCvet
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Identifiers
IUPAC name (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number	2135-17-3 Y
PubChem CID	16490
UNII	LR3CD8SX89
KEGG	D04208 Y
ChEMBL	ChEMBL1201392 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H28F2O5
Molar mass	410.452 g/mol
NY (what is this?)  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Flumethasone (usually as the pivalic acid ester flumethasone pivalate, trade name Locacorten or Locorten) is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.

Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.

Synthesis

See also

• Glucocorticoid
• Corticosteroid
• Triamcinolone acetonide