FABP3

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Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
PDB rendering based on 1g5w.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols FABP3 ; FABP11; H-FABP; MDGI; O-FABP
External IDs Template:OMIM5 Template:MGI HomoloGene68379
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor), also known as FABP3, is a human gene.[1]

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer.[1]

References

  1. 1.0 1.1 "Entrez Gene: FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)".

Further reading

  • Spener F, Unterberg C, Börchers T, Grosse R (1991). "Characteristics of fatty acid-binding proteins and their relation to mammary-derived growth inhibitor". Mol. Cell. Biochem. 98 (1–2): 57–68. PMID 2266970.
  • Zanotti G, Scapin G, Spadon P; et al. (1992). "Three-dimensional structure of recombinant human muscle fatty acid-binding protein". J. Biol. Chem. 267 (26): 18541–50. PMID 1526991.
  • Peeters RA, Veerkamp JH, Geurts van Kessel A; et al. (1991). "Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization". Biochem. J. 276 ( Pt 1): 203–7. PMID 1710107.
  • Tanaka T, Hirota Y, Sohmiya K; et al. (1991). "Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction". Clin. Biochem. 24 (2): 195–201. PMID 2040092.
  • Börchers T, Højrup P, Nielsen SU; et al. (1991). "Revision of the amino acid sequence of human heart fatty acid-binding protein". Mol. Cell. Biochem. 98 (1–2): 127–33. PMID 2266954.
  • Offner GD, Brecher P, Sawlivich WB; et al. (1988). "Characterization and amino acid sequence of a fatty acid-binding protein from human heart". Biochem. J. 252 (1): 191–8. PMID 3421901.
  • Kovalyov LI, Shishkin SS, Efimochkin AS; et al. (1996). "The major protein expression profile and two-dimensional protein database of human heart". Electrophoresis. 16 (7): 1160–9. PMID 7498159.
  • Nielsen SU, Spener F (1993). "Fatty acid-binding protein from rat heart is phosphorylated on Tyr19 in response to insulin stimulation". J. Lipid Res. 34 (8): 1355–66. PMID 7691977.
  • Huynh HT, Larsson C, Narod S, Pollak M (1995). "Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor". Cancer Res. 55 (11): 2225–31. PMID 7757968.
  • Young AC, Scapin G, Kromminga A; et al. (1994). "Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids". Structure. 2 (6): 523–34. PMID 7922029.
  • Yang Y, Spitzer E, Kenney N; et al. (1994). "Members of the fatty acid binding protein family are differentiation factors for the mammary gland". J. Cell Biol. 127 (4): 1097–109. PMID 7962070.
  • Troxler RF, Offner GD, Jiang JW; et al. (1994). "Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33". Hum. Genet. 92 (6): 563–6. PMID 8262516.
  • Watanabe K, Wakabayashi H, Veerkamp JH; et al. (1993). "Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct". J. Pathol. 170 (1): 59–65. doi:10.1002/path.1711700110. PMID 8326460.
  • Phelan CM, Larsson C, Baird S; et al. (1996). "The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors". Genomics. 34 (1): 63–8. doi:10.1006/geno.1996.0241. PMID 8661024.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Zhao Y, Meng XM, Wei YJ; et al. (2004). "Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I.". J. Mol. Med. 81 (5): 297–304. doi:10.1007/s00109-003-0427-x. PMID 12721663.
  • Cheon MS, Kim SH, Fountoulakis M, Lubec G (2004). "Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (67): 225–34. PMID 15068254.
  • Hashimoto T, Kusakabe T, Sugino T; et al. (2005). "Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis". Pathobiology. 71 (5): 267–73. doi:10.1159/000080061. PMID 15459486.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

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