Etanautine

Etanautine

Clinical data
ATC code	N04AB01 (WHO)
Identifiers
IUPAC name 2-[di(phenyl)methoxy]-N,N-dimethylethanamine; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid
CAS Number	88637-37-0 Y
ChemSpider	8430627
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C26H31N5O5
Molar mass	493.555 g/mol
3D model (JSmol)	Interactive image
SMILES O=C2N(c1ncn(c1C(=O)N2C)CC(=O)O)C.O(CCN(C)C)C(c1ccccc1)c2ccccc2
InChI InChI=1S/C17H21NO.C9H10N4O4/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h3-12,17H,13-14H2,1-2H3;4H,3H2,1-2H3,(H,14,15) Key:UFKLOBYBVCBTBP-UHFFFAOYSA-N
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List of terms related to Etanautine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Etanautine, also known as diphenhydramine monoacefyllinate, is an anticholinergic used as an antiparkinsonian agent. It is a 1:1 salt of diphenhydramine with acefylline, similar to the diphenhydramine/8-chlorotheophylline combination product dimenhydrinate.

As with dimenhydrinate, the stimulant effect of the acefylline counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.

The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine.