Endomyocardial fibrosis

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Endomyocardial fibrosis
Left ventricular endocardial fibrosis due to implantable defibrillator.
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and related keywords: Davies' disease, EMF, Fibroelastic endocarditis, Loeffler endomyocardial fibrosis with eosinophilia, Loeffler fibroplastic parietal endocarditis and Loeffler's disease. [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34]

Endomyocardial fibrosis or endocardial fibrosis may seen as;

  • Left ventricular fibrosis
  • Right ventricular fibrosis
  • Biventricular fibrosis

Pathological Findings

Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology



  1. Barretto AC, Mady C, Oliveira SA, et al. Clinical meaning of ascites in patients with endomyocardial fibrosis. Arq Bras Cardiol. Feb 2002;78(2):196-9.
  2. Brockington IF, Edington GM. Adult heart disease in western Nigeria: a clinicopathological synopsis. Am Heart J. Jan 1972;83(1):27-40.
  3. Chopra P, Narula J, Talwar KK, et al. Histomorphologic characteristics of endomyocardial fibrosis: an endomyocardial biopsy study. Hum Pathol. Jun 1990;21(6):613-6.
  4. Eling WM, Jerusalem CR, Heinen-Borries UJ, et al. Is malaria involved in the pathogenesis of tropical endomyocardial fibrosis?. Acta Leiden. 1988;57(1):47-52.
  5. Falase AO. Aetiological considerations in Nigeria. In: Valiathan MS, Somers K, Kartha CC, eds. Endomyocardial Fibrosis. Oxford, England:. Oxford Univ Press;1993:88, 94.
  6. Freers J, Mayanja-Kizza H, Ziegler JL, Rutakingirwa M. Echocardiographic diagnosis of heart disease in Uganda. Trop Doct. Jul 1996;26(3):125-8.
  7. Freers J, Mayanja-Kizza H, Rutakingirwa M, Gerwing E. Endomyocardial fibrosis: why is there striking ascites with little or no peripheral oedema?. Lancet. Jan 20 1996;347(8995):197.
  8. Goo HW, Han NJ, Lim TH. Endomyocardial fibrosis mimicking right ventricular tumor. AJR Am J Roentgenol. Jul 2001;177(1):205-6.
  9. Gupta PN, Valiathan MS, Balakrishnan KG, et al. Clinical course of endomyocardial fibrosis. Br Heart J. Dec 1989;62(6):450-4.
  10. Jatene MB, Contreras IS, Lameda LC, et al. Endomyocardial fibrosis in infancy. Arq Bras Cardiol. Apr 2003;80(4):438-45.
  11. Lowenthal MN. Endomyocardial fibrosis: familial and other cases from northern Zambia. Med J Zambia. 1978 Feb-Mar;12(1):2-7. 1978;12:2-7.
  12. Metras D, Coulibaly AO, Ouattara K. The surgical treatment of endomyocardial fibrosis: results in 55 patients. Circulation. Sep 1985;72(3 Pt 2):II274-9.
  13. Metras D. Endomyocardial fibrosis and its surgical treatment: Ivory Coast experience. In: Valiathan MS, Somers K, Kartha CC, eds. Endomyocardial Fibrosis. Oxford, England:. Oxford Univ Press;1993:207-19.
  14. Moraes CR, Buffolo E, Victor E, et al. Endomyocardial fibrosis: report of 6 patients and review of the surgical literature. Ann Thorac Surg. Mar 1980;29(3):243-8.
  15. Mousseaux E, Hernigou A, Azencot M, et al. Endomyocardial fibrosis: electron-beam CT features. Radiology. Mar 1996;198(3):755-60.
  16. Nieveen J, Huber J. Familial myocardial fibrosis. Acta Med Scand. Nov 1970;188(5):439-45.
  17. Niino T, Shiono M, Yamamoto T, et al. A case of left ventricular endomyocardial fibrosis. Ann Thorac Cardiovasc Surg. Jun 2002;8(3):173-6.
  18. Parry EH, Abrahams DG. The natural history of endomyocardial fibrosis. Q J Med. Oct 1965;34(136):383-408.
  19. Patel AK, Ziegler JL, DArbela PG, Somers K. Familial cases of endomyocardial fibrosis in Uganda. Br Med J. Nov 6 1971;4(783):331-4.
  20. Puvaneswary M, Joshua F, Ratnarajah S. Idiopathic hypereosinophilic syndrome: magnetic resonance imaging findings in endomyocardial fibrosis. Australas Radiol. Nov 2001;45(4):524-7.
  21. Radhakumary C, Kumari TV, Kartha CC. Endomyocardial fibrosis is associated with selective deposition of type I collagen. Indian Heart J. Jul-Aug 2001;53(4):486-9.
  22. Roberts WC, Liegler DG, Carbone PP. Endomyocardial disease and eosinophilia. A clinical and pathologic spectrum. Am J Med. Jan 1969;46(1):28-42.
  23. Salemi VM, Picard MH, Mady C. Assessment of diastolic function in endomyocardial fibrosis: value of flow propagation velocity. Artif Organs. Apr 2004;28(4):343-6.
  24. Shaper AG. The etiology of endomyocardial fibrosis. In: Valiathan MS, Somers K, Kartha CC, eds. Endomyocardial Fibrosis. Oxford, England: Oxford University Press;1993:113.
  25. Shaper AG, Hutt MS, Coles RM. Necropsy study of endomyocardial fibrosis and rheumatic heart disease in Uganda 1950-1965. Br Heart J. May 1968;30(3):391-401.
  26. Smedema JP, Winckels SK, Snoep G, et al. Tropical endomyocardial fibrosis (Davies disease): case report demonstrating the role of magnetic resonance imaging. Int J Cardiovasc Imaging. Dec 2004;20(6):517-22.
  27. Somers K, Hutt MS, Patel AK, DArbela PG. Endomyocardial biopsy in diagnosis of cardiomyopathies. Br Heart J. Nov 1971;33(6):822-32.
  28. Somsen GA, Duren DR. [Heart failure in a Ghanese woman due to endomyocardial fibrosis]. Ned Tijdschr Geneeskd. Aug 26 1995;139(34):1746-8.
  29. Urhoghide GE, Falase AO. Degranulated eosinophils, eosinophil granule basic proteins and humoral factors in Nigerians with endomyocardial fibrosis. Afr J Med Med Sci. Sep 1987;16(3):133-9.
  30. Valiathan MS, Kartha CC, Panday VK, et al. A geochemical basis for endomyocardial fibrosis. Cardiovasc Res. Sep 1986;20(9):679-82
  31. Valiathan MS, Kartha CC. Geochemical basis of tropical endomyocardial fibrosis. In: Valiathan MS, Somers K, Kartha CC, eds. Endomyocardial Fibrosis. Oxford, England:. Oxford University Press;1993:98.
  32. Valiathan MS, Balakrishnan KG, Sankarkumar R, Kartha CC. Surgical treatment of endomyocardial fibrosis. Ann Thorac Surg. Jan 1987;43(1):68-73.
  33. Wynne J, Braunwald E. The cardiomyopathies and myocarditides. In: Braunwald E, ed. Heart Disease. 5th ed. Philadelphia, Pa:. WB Saunders and Co;1997:1433-4.
  34. Zabsonre P, Renambot J, Adoh-Adoh M, et al. [Conduction disorders in chronic parietal endocarditis or endomyocardial fibrosis.170 cases at the Cardiology Institute of Abidjan.]. Dakar Med. 2000;45(1):15-9.

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