Endometrial cancer medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]
Overview
The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
Medical Therapy
- The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
- Chemotherapy is not the first-line treatment option for patients with stage I-III endometrial cancer. Surgery is the mainstay of treatment.
- Chemotherapy without prior surgery is usually reserved for patients with stage IV endometrial cancer or patients that are not surgical candidates.
- Typically a platinum based combination regimen or triple druge therapy is used:[1]
- Endocrine therapy is also used with favorable results in patients with:[2]
- Endometroid endmetrial cancer
- Express estrogen and progesterone receptors
- Asymptomatic disease
References
- ↑ Fleming GF (2007). "Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant". J Clin Oncol. 25 (20): 2983–90. doi:10.1200/JCO.2007.10.8431. PMID 17617530.
- ↑ Decruze SB, Green JA (2007). "Hormone therapy in advanced and recurrent endometrial cancer: a systematic review". Int J Gynecol Cancer. 17 (5): 964–78. doi:10.1111/j.1525-1438.2007.00897.x. PMID 17442022.