Endometrial cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:

Type	Histology	Prognosis	Pathogenesis	Prevalence
Type I	Endometroid (adenocarcinoma)	Favorable (estrogen-responsive)	• May arise from atypical hyperplasia • Linked to unopposed estrogen stimulation	80%
Type II	• Endometroid • Serous • Clear cell • Mucinous • Squamous • Mesonephric • Undifferentiated	Typically bad prognosis	• Develops from atrophic endometrium • Not linked to hormonally driven pathogenesis	15-20%

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