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EPH receptor A5
Symbols EPHA5 ; TYRO4; CEK7; EHK1; HEK7
External IDs Template:OMIM5 Template:MGI HomoloGene55824
RNA expression pattern
PBB GE EPHA5 215664 s at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

EPH receptor A5, also known as EPHA5, is a human gene.[1]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[1]


  1. 1.0 1.1 "Entrez Gene: EPHA5 EPH receptor A5".

Further reading

  • Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands". Cell Tissue Res. 290 (2): 251–9. PMID 9321686.
  • Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1". Cell Tissue Res. 290 (2): 261–4. PMID 9321687.
  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
  • Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
  • Spritz RA, Strunk KM, Lee ST; et al. (1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
  • Fox GM, Holst PL, Chute HT; et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897–905. PMID 7898931.
  • Davis S, Gale NW, Aldrich TH; et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9. PMID 7973638.
  • Gale NW, Holland SJ, Valenzuela DM; et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. PMID 8755474.
  • Miescher GC, Taylor V, Olivieri G; et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors". Brain Res. Mol. Brain Res. 46 (1–2): 17–24. PMID 9191074.
  • "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. 1997. PMID 9267020.
  • Stein E, Savaskan NE, Ninnemann O; et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885–93. PMID 10516308.

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