Duodenal atresia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]


In 1900, J. Tandler reported duodenal stenosis due to failure of recanalization of duodenum during fetal development in pregnancy. In 1961, Thomas Santulli and William Blanc described the figure 8 formation of small bowel, which is described as apple-peel intestinal atresia. In 1936, William Ladd developed a surgical procedure to correct the duodenal malrotation.

Historical Perspective


Duodenal atresia discovery is as follows:[1][2]

  • In 1900, J. Tandler was the first to discover the association of duodenal stenosis due to failure of recanalization of the embryonic duodenum and the development of duodenal atresia.
  • In 1961, Thomas V. Santulli and William A. Blanc described apple-peel intestinal atresia, which is the figure 8 formation of the small bowel.

Landmark Events in the Development of Treatment Strategies

  • In 1936, a surgical procedure was developed by William Ladd to to correct the malrotation of duodenal atresia.[3]


  1. Tandler J. Zur entwicklungsdes chichte des menschlichen duodenum in fruhen embry-onalstedien. Morphol Jahrb 1900; 29: 187
  2. SANTULLI TV, BLANC WA (1961). "Congenital atresia of the intestine: pathogenesis and treatment". Ann Surg. 154: 939–48. PMC 1465932. PMID 14497096.
  3. Morris, Grant; Kennedy, Alfred; Cochran, William (2016). "Small Bowel Congenital Anomalies: a Review and Update". Current Gastroenterology Reports. 18 (4). doi:10.1007/s11894-016-0490-4. ISSN 1522-8037.

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