Cutaneous small vessel vasculitis

Jump to navigation Jump to search

WikiDoc Resources for Cutaneous small vessel vasculitis

Articles

Most recent articles on Cutaneous small vessel vasculitis

Most cited articles on Cutaneous small vessel vasculitis

Review articles on Cutaneous small vessel vasculitis

Articles on Cutaneous small vessel vasculitis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Cutaneous small vessel vasculitis

Images of Cutaneous small vessel vasculitis

Photos of Cutaneous small vessel vasculitis

Podcasts & MP3s on Cutaneous small vessel vasculitis

Videos on Cutaneous small vessel vasculitis

Evidence Based Medicine

Cochrane Collaboration on Cutaneous small vessel vasculitis

Bandolier on Cutaneous small vessel vasculitis

TRIP on Cutaneous small vessel vasculitis

Clinical Trials

Ongoing Trials on Cutaneous small vessel vasculitis at Clinical Trials.gov

Trial results on Cutaneous small vessel vasculitis

Clinical Trials on Cutaneous small vessel vasculitis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Cutaneous small vessel vasculitis

NICE Guidance on Cutaneous small vessel vasculitis

NHS PRODIGY Guidance

FDA on Cutaneous small vessel vasculitis

CDC on Cutaneous small vessel vasculitis

Books

Books on Cutaneous small vessel vasculitis

News

Cutaneous small vessel vasculitis in the news

Be alerted to news on Cutaneous small vessel vasculitis

News trends on Cutaneous small vessel vasculitis

Commentary

Blogs on Cutaneous small vessel vasculitis

Definitions

Definitions of Cutaneous small vessel vasculitis

Patient Resources / Community

Patient resources on Cutaneous small vessel vasculitis

Discussion groups on Cutaneous small vessel vasculitis

Patient Handouts on Cutaneous small vessel vasculitis

Directions to Hospitals Treating Cutaneous small vessel vasculitis

Risk calculators and risk factors for Cutaneous small vessel vasculitis

Healthcare Provider Resources

Symptoms of Cutaneous small vessel vasculitis

Causes & Risk Factors for Cutaneous small vessel vasculitis

Diagnostic studies for Cutaneous small vessel vasculitis

Treatment of Cutaneous small vessel vasculitis

Continuing Medical Education (CME)

CME Programs on Cutaneous small vessel vasculitis

International

Cutaneous small vessel vasculitis en Espanol

Cutaneous small vessel vasculitis en Francais

Business

Cutaneous small vessel vasculitis in the Marketplace

Patents on Cutaneous small vessel vasculitis

Experimental / Informatics

List of terms related to Cutaneous small vessel vasculitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2].

Synonyms and keywords: Cutaneous leukocytoclastic angiitis, cutaneous leukocytoclastic vasculitis, cutaneous necrotizing venulitis, hypersensitivity angiitis.

Overview

Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis,"[1] "Cutaneous leukocytoclastic vasculitis,"[1] "Cutaneous necrotizing venulitis,"[1] and "Hypersensitivity angiitis"[1]) is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura.[2]:831[3] It is the most common vasculitis seen in clinical practice. Leukocytoclasis refers to the damage caused by nuclear debris from infiltrating neutrophils in and around the vessels.[4]

Subtypes of small-vessel vasculitis include:[2]:833–6


Historical Perspective

  • [Disease name] was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
  • In [year], [gene] mutations were first identified in the pathogenesis of [disease name].
  • In [year], the first [discovery] was developed by [scientist] to treat/diagnose [disease name].

Classification

  • [Disease name] may be classified according to [classification method] into [number] subtypes/groups:
  • [group1]
  • [group2]
  • [group3]
  • Other variants of [disease name] include [disease subtype 1], [disease subtype 2], and [disease subtype 3].

Pathophysiology

  • The pathogenesis of [disease name] is characterized by [feature1], [feature2], and [feature3].
  • The [gene name] gene/Mutation in [gene name] has been associated with the development of [disease name], involving the [molecular pathway] pathway.
  • On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
  • On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Causes

  • [Disease name] may be caused by either [cause1], [cause2], or [cause3].
  • [Disease name] is caused by a mutation in the [gene1], [gene2], or [gene3] gene[s].
  • There are no established causes for [disease name].

Differentiating [disease name] from other Diseases

  • [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
  • [Differential dx1]
  • [Differential dx2]
  • [Differential dx3]

Epidemiology and Demographics

  • The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Patients of all age groups may develop [disease name].
  • [Disease name] is more commonly observed among patients aged [age range] years old.
  • [Disease name] is more commonly observed among [elderly patients/young patients/children].

Gender

  • [Disease name] affects men and women equally.
  • [Gender 1] are more commonly affected with [disease name] than [gender 2].
  • The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

  • There is no racial predilection for [disease name].
  • [Disease name] usually affects individuals of the [race 1] race.
  • [Race 2] individuals are less likely to develop [disease name].

Risk Factors

  • Common risk factors in the development of [disease name] are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

  • The majority of patients with [disease name] remain asymptomatic for [duration/years].
  • Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
  • If left untreated, [#%] of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
  • Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with [disease name] is approximately [#%].

Diagnosis

Diagnostic Criteria

  • The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:
  • [criterion 1]
  • [criterion 2]
  • [criterion 3]
  • [criterion 4]

Symptoms

  • [Disease name] is usually asymptomatic.
  • Symptoms of [disease name] may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical examination

Gallery

Skin

Extremities
Trunk


Laboratory Findings

  • There are no specific laboratory findings associated with [disease name].
  • A [positive/negative] [test name] is diagnostic of [disease name].
  • An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].
  • Other laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

  • There are no [imaging study] findings associated with [disease name].
  • [Imaging study 1] is the imaging modality of choice for [disease name].
  • On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • [Disease name] may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for [disease name]; the mainstay of therapy is supportive care.
  • The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action 1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for [disease name].
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
  • [Surgical procedure] can only be performed for patients with [disease stage] [disease name].

Prevention

  • There are no primary preventive measures available for [disease name].
  • Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with [disease name] are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].

References

  1. 1.0 1.1 1.2 1.3 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  2. 2.0 2.1 James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  3. Lotti T, Ghersetich I, Comacchi C, Jorizzo JL (November 1998). "Cutaneous small-vessel vasculitis". J. Am. Acad. Dermatol. 39 (5 Pt 1): 667–87, quiz 688–90. doi:10.1016/S0190-9622(98)70039-8. PMID 9810883.
  4. Harrison's Principles of Internal Medicine. 18th edition. Page 2798.

Template:WS Template:WH