Clostridium difficile infection Biopsy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.
Overview
On microscopic examination, erosions within colonic crypts or formation of mushroom-like exudates with hemorrhage and necrosis are characteristic features of C. difficile infection.
Biopsy Findings
On microsopic pathology, the following characteristic features may be present in C. difficile colitis:
- Erosions within colonic crypts with pseudomembrane formation, which contains neutrophils, fibrin, and necrotic debris
- Linear neutrophilic infiltration at the level of the lamina propria and within areas of necrosis
- Necrotizing enteritis with or without hemorrhage
- Submucosal edema
- Inflammatory exudates (mushroom-like)