Chorioamnionitis primary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
Effective measures for the primary prevention of chorioamnionitis include induction of labor after 34 weeks of gestation and administration of prophylactic antimicrobial therapy in the presence of preterm premature rupture of membranes (PPROM).
Primary Prevention
Effective measures for the primary prevention of chorioamnionitis in the presence of preterm premature rupture of membranes include:[1][2]
- induction of labor after 34 weeks of gestation
- Prophylactic antimicrobial regimen
- Preferred regimen: Macrolide (Erythromycin OR Azithromycin) AND Ampicillin for 7–10 days (IV for 2 days followed by oral routes)
The use of intrapartum ampicillin-sulbactam might be an effective measure for the primary prevention of chorioamnionitis in the presence of meconium-stained fluid.
References
- ↑ Fishman SG, Gelber SE (2012). "Evidence for the clinical management of chorioamnionitis". Semin Fetal Neonatal Med. 17 (1): 46–50. doi:10.1016/j.siny.2011.09.002. PMID 21962477.
- ↑ Tita AT, Andrews WW (June 2010). "Diagnosis and management of clinical chorioamnionitis". Clin Perinatol. 37 (2): 339–54. doi:10.1016/j.clp.2010.02.003. PMC 3008318. PMID 20569811.