Castleman's disease classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Classification

Two types of classifications exist for Castleman's disease. They are:

• Clinical and Radiologic classification:
  • Unicentric - single lymph node is involved, most commonly in the mediastinum or the mesentery.
  • Multicentric - wide spread involvement of lymph nodes and also liver and spleen in some cases

• Histopathologic classification:
  • Hyaline vascular
  • Plasmacytic
  • Mixed cellularity - has features of both hyaline vascular type and plasmacytic type.