Campylobacteriosis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical therapy of campylobacteriosis mainly consist of supportive therapy. Antibiotics is reserved for severe cases of gastroenteritis and other extraintestinal infections
Medical Therapy
In most cases, reposition of liquid and electrolytes is enough. The use of antibiotics is controversial. Some studies show that erythromycin rapidly eliminates Campylobacter from the stool without affecting the duration of illness. Studies in children with dysentery due to C jejuni have shown benefit from early treatment with erythromycin. Treatment with antibiotics, therefore, depends on the severity of symptoms. Antimotility agents, such as loperamide, can lead to prolonged illness or intestinal perforation in any invasive diarrhea, and should be avoided.
Antimicrobial regimen
- 1. Gastroenteritis[1]
- Most patients donot require antibiotics and symptoms last < 1 week
- 1.1 Indications for the treatment
- Highfevers
- Bloodystools
- Prolonged illness > 1 week
- Pregnancy
- HIV and other immunosuppressed states
- 1.2 Treatment regimen [2]
- Preferred regimen (1):Erythromycin stearate 500 mg PO bid for 5 days
- Preferred regimen (2): Ciprofloxacin 500 mg PO bid for 3–5 days
- Alternative regimen (1): TMP-SMX DS PO bid for 3–5 days
- Note (1): Campylobacter resistance to TMP-SMX common in tropics
- Note (2): Extraintestinal infections should be treated for longer duration (e.g.,2-4 weeks)
References
- ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
- ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.