Buerger's disease causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Buerger's disease may be caused by tobacco smoking, rickettsial infection, or autoimmune phenomena.

Causes

Buerger's disease may be caused by:

• Tobacco smoking
• Rickettsiae
• Autoimmune phenomenon

Genetic Causes

• Buerger disease may be caused by a mutation in DRBl*0405, DQAl *03, DQBl*0401, DPBl*0501, HLA-A54, HLA-A9,and HLA-B54 genes.

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	Smoking
Gastroenterologic	No underlying causes
Genetic	DRBl*0405, DQAl *03, DQBl*0401, DPBl*0501, HLA-A54, HLA-A9,and HLA-B54
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	Rickettsial infection
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Autoimmune with presence of anti-endothelial cell antibody and anti-cardiolipin antibodies
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

• Autoimmune with presence of anti-endothelial cell antibody and anti-cardiolipin antibodies
• DRBl*0405, DQAl *03, DQBl*0401, DPBl*0501
• HLA-A54, HLA-A9,and HLA-B54
• Rickettsial infection
• Smoking