BMP15 (gene)

Bone morphogenetic protein 15
Identifiers
Symbols	BMP15 ; GDF9B; ODG2; POF4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3977
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Bone morphogenetic protein 15, also known as BMP15, is a human gene.

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.

Further reading

• Dube JL, Wang P, Elvin J; et al. (1999). "The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes". Mol. Endocrinol. 12 (12): 1809–17. PMID 9849956.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aaltonen J, Laitinen MP, Vuojolainen K; et al. (1999). "Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis". J. Clin. Endocrinol. Metab. 84 (8): 2744–50. PMID 10443672.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galloway SM, McNatty KP, Cambridge LM; et al. (2000). "Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner". Nat. Genet. 25 (3): 279–83. doi:10.1038/77033. PMID 10888873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuka F, Yao Z, Lee T; et al. (2001). "Bone morphogenetic protein-15. Identification of target cells and biological functions". J. Biol. Chem. 275 (50): 39523–8. doi:10.1074/jbc.M007428200. PMID 10998422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuka F, Moore RK, Iemura S; et al. (2002). "Follistatin inhibits the function of the oocyte-derived factor BMP-15". Biochem. Biophys. Res. Commun. 289 (5): 961–6. doi:10.1006/bbrc.2001.6103. PMID 11741284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moore RK, Otsuka F, Shimasaki S (2003). "Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells". J. Biol. Chem. 278 (1): 304–10. doi:10.1074/jbc.M207362200. PMID 12419820.CS1 maint: Multiple names: authors list (link)
• Liao WX, Moore RK, Otsuka F, Shimasaki S (2003). "Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep". J. Biol. Chem. 278 (6): 3713–9. doi:10.1074/jbc.M210598200. PMID 12446716.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liao WX, Moore RK, Shimasaki S (2004). "Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9". J. Biol. Chem. 279 (17): 17391–6. doi:10.1074/jbc.M401050200. PMID 14970198.CS1 maint: Multiple names: authors list (link)
• Di Pasquale E, Beck-Peccoz P, Persani L (2004). "Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene". Am. J. Hum. Genet. 75 (1): 106–11. doi:10.1086/422103. PMID 15136966.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto O, Moore RK, Shimasaki S (2005). "Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota". Proc. Natl. Acad. Sci. U.S.A. 102 (15): 5426–31. doi:10.1073/pnas.0409533102. PMID 15809424.CS1 maint: Multiple names: authors list (link)
• Dixit H, Rao LK, Padmalatha VV; et al. (2006). "Missense mutations in the BMP15 gene are associated with ovarian failure". Hum. Genet. 119 (4): 408–15. doi:10.1007/s00439-006-0150-0. PMID 16508750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laissue P, Christin-Maitre S, Touraine P; et al. (2006). "Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure". Eur. J. Endocrinol. 154 (5): 739–44. doi:10.1530/eje.1.02135. PMID 16645022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chand AL, Ponnampalam AP, Harris SE; et al. (2006). "Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure". Fertil. Steril. 86 (4): 1009–12. doi:10.1016/j.fertnstert.2006.02.107. PMID 17027369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)