BCL2L11

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.

Function

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Regulation of Bim

Bim expression and activity are regulated at the transcriptional, translational and post-translational levels; coordinated expression and activity of Bim shape immune responses, and ensure tissue integrity. Cancer cells develop mechanisms that suppress Bim expression, which allows for tumor progression and metastasis.

Interactions

BCL2L11 has been shown to interact with:

• BCL2-like 1,
• BCL2L2,
• Bcl-2,
• DYNLL1, and
• MCL1.

See also

• Bcl-2

Further reading

• Wang K, Yin XM, Chao DT, et al. (1996). "BID: a novel BH3 domain-only death agonist". Genes Dev. 10 (22): 2859–69. doi:10.1101/gad.10.22.2859. PMID 8918887.
• Zha J, Harada H, Yang E, et al. (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell. 87 (4): 619–28. doi:10.1016/S0092-8674(00)81382-3. PMID 8929531.
• Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMC 1170452. PMID 9463381.
• Puthalakath H, Huang DC, O'Reilly LA, et al. (1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex". Mol. Cell. 3 (3): 287–96. doi:10.1016/S1097-2765(00)80456-6. PMID 10198631.
• Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
• Bouillet P, Metcalf D, Huang DC, et al. (1999). "Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity". Science. 286 (5445): 1735–8. doi:10.1126/science.286.5445.1735. PMID 10576740.
• Dijkers PF, Medema RH, Lammers JW, et al. (2000). "Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1". Curr. Biol. 10 (19): 1201–4. doi:10.1016/S0960-9822(00)00728-4. PMID 11050388.
• Bouillet P, Zhang LC, Huang DC, et al. (2001). "Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim". Mamm. Genome. 12 (2): 163–8. doi:10.1007/s003350010242. PMID 11210187.
• Putcha GV, Moulder KL, Golden JP, et al. (2001). "Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis". Neuron. 29 (3): 615–28. doi:10.1016/S0896-6273(01)00238-0. PMID 11301022.
• Murray S, Halford S, Ebenezer ND, et al. (2001). "Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids". Cytogenet. Cell Genet. 92 (3–4): 353. doi:10.1159/000056930. PMID 11435715.
• Cheng EH, Wei MC, Weiler S, et al. (2001). "BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis". Mol. Cell. 8 (3): 705–11. doi:10.1016/S1097-2765(01)00320-3. PMID 11583631.
• Mami U, Miyashita T, Shikama Y, et al. (2002). "Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family". FEBS Lett. 509 (1): 135–41. doi:10.1016/S0014-5793(01)03145-3. PMID 11734221.
• Bouillet P, Purton JF, Godfrey DI, et al. (2002). "BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes". Nature. 415 (6874): 922–6. doi:10.1038/415922a. PMID 11859372.
• Marani M, Tenev T, Hancock D, et al. (2002). "Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis". Mol. Cell. Biol. 22 (11): 3577–89. doi:10.1128/MCB.22.11.3577-3589.2002. PMC 133811. PMID 11997495.
• Liu JW, Chandra D, Tang SH, et al. (2002). "Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim". Cancer Res. 62 (10): 2976–81. PMID 12019181.
• Terradillos O, Montessuit S, Huang DC, Martinou JC (2002). "Direct addition of BimL to mitochondria does not lead to cytochrome c release". FEBS Lett. 522 (1–3): 29–34. doi:10.1016/S0014-5793(02)02871-5. PMID 12095614.
• Sugiyama T, Shimizu S, Matsuoka Y, et al. (2002). "Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim". Oncogene. 21 (32): 4944–56. doi:10.1038/sj.onc.1205621. PMID 12118373.

External links

• BCL2L11 human gene location in the UCSC Genome Browser.
• BCL2L11 human gene details in the UCSC Genome Browser.