B-cell lymphoma physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]

Overview

Common physical examination findings of B cell lymphomas include peripheral lymphadenopathy, central lymphadenopathy, fever, pruritus, pallor, petechiae, jaundice, chest tenderness, abdominal distension, abdominal tenderness, and hepatosplenomegaly.

Physical Examination

The following physical examination findings may be present among patients with B cell lymphomas:[1][2][3][4][5]

Appearance of the Patient

  • Appearance of the Patients with B cell lymphomas depends on the stage of disease. Patients may present with cachexia in late disease stage.

Vital Signs

Skin

HEENT

  • Abnormalities of the head/hair may include:
  • Patients may develop superior vena cava syndrome, which may present with:
    • Swelling of the face
    • Facial flushing/redness face or cheeks
    • Facial tenderness
    • Drooping eyelid
    • Swelling around the eye

Neck

Lungs

  • Thoracic masses suggestive of central lymphadenopathy
  • Chest tenderness
  • Pleural effusion may develop, which has signs and symptoms such as:
    • Wheezing
    • Decreased breath sounds
    • Asymmetric chest expansion
    • Hyperresonance lungs on chest auscultation

Heart

  • Cardiovascular examination of patients with B cell lymphomas is usually normal.

Abdomen

Back

  • Back examination of patients with B cell lymphomas is usually normal.

Genitourinary

  • Genitourinary examination of patients with B cell lymphomas is usually normal.

Neuromuscular

  • Neuromuscular examination of patients with B cell lymphomas is usually normal.

Extremities

CNS

References

  1. "StatPearls". 2022. PMID 32644754 Check |pmid= value (help).
  2. "StatPearls". 2022. PMID 29763144.
  3. Hingorjo MR, Syed S (2008). "Presentation, staging and diagnosis of lymphoma: a clinical perspective". J Ayub Med Coll Abbottabad. 20 (4): 100–3. PMID 19999217.
  4. Armitage JO, Gascoyne RD, Lunning MA, Cavalli F (2017). "Non-Hodgkin lymphoma". Lancet. 390 (10091): 298–310. doi:10.1016/S0140-6736(16)32407-2. PMID 28153383.
  5. Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH; et al. (2020). "Hodgkin lymphoma". Nat Rev Dis Primers. 6 (1): 61. doi:10.1038/s41572-020-0189-6. PMID 32703953 Check |pmid= value (help).


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