Anaplastic large cell lymphoma diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Diagnostic Criteria

To make this diagnosis under its present system of classification, the WHO:

Requires

• The presence of "hallmark" cells
• Immunopositivity for CD30

Acknowledges as typical, but does not require

• Immunopositivity for ALK (anaplastic lymphoma kinase) protein

Specifically excludes

• Primary cutaneous T-cell lymphomas
• Other specific types of anaplastic lymphoma (particularly those of B-cell lineage) with CD30 positivity