2-Butyl-3-(p-tolyl)quinuclidine

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2-Butyl-3-(p-tolyl)quinuclidine
File:2-Butyl-3-(p-tolyl)quinuclidine.png
Legal status
Legal status
  • In general: legal
Identifiers
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC18H27N
Molar mass257.414 g/mol
3D model (JSmol)

2-Butyl-3-(p-tolyl)quinuclidine (BTQ) is a stimulant drug which acts as a dopamine reuptake inhibitor.[1] It is one of a number of substituted quinuclidine derivatives developed as potential medications for the treatment of cocaine abuse,[2][3] and produces similar effects to cocaine in animal studies, although milder and longer lasting.

References

  1. ↑ Sakamuri S, Enyedy IJ, Kozokowski AP, Wang S. Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors. Tetrahedron Letters. 2000; 41:9949-9952.
  2. ↑ Sakamuri S, Enyedy IJ, Zaman WA, Tella SR, Kozikowski AP, Flippen-Anderson JL, Farkas T, Johnson KM, Wang S. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic and Medicinal Chemistry. 2003 Mar 20;11(6):1123-36. PMID 12614900
  3. ↑ Enyedy IJ, Sakamuri S, Zaman WA, Johnson KM, Wang S. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic and Medicinal Chemistry Letters. 2003 Feb 10;13(3):513-7. PMID 12565962


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