17 alpha-hydroxylase deficiency natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2], Mehrian Jafarizade, M.D [3]

Overview

If left untreated, patients with 17 alpha-hydroxylase deficiency may progress to develop malignant hypertension. Common complications of 17 alpha-hydroxylase deficiency include muscle weakness, metabolic alkalosis, and infertility. Prognosis is generally good with treatment.

Natural History

If left untreated, patients with 17 alpha-hydroxylase deficiency may progress to develop malignant hypertension.

Complications

Complications of Hypertension

• Vascular hemorrhage
• Renal insufficiency
• Left ventricular hypertrophy
• Hypertensive retinopathy
• Stroke

Complications of Hypokalemia

• Muscle weakness
• Metabolic alkalosis
• Paralytic ileus

Other Complications

• Infertility

Prognosis

• The prognosis of 17 alpha-hydroxylase deficiency is generally good or excellent.