(Redirected from 17-hydroxypregnenolone)
Jump to navigation Jump to search
Pharmacokinetic data
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass332.48 g/mol
Melting point268 °C (514.4 °F)

WikiDoc Resources for 17-Hydroxypregnenolone


Most recent articles on 17-Hydroxypregnenolone

Most cited articles on 17-Hydroxypregnenolone

Review articles on 17-Hydroxypregnenolone

Articles on 17-Hydroxypregnenolone in N Eng J Med, Lancet, BMJ


Powerpoint slides on 17-Hydroxypregnenolone

Images of 17-Hydroxypregnenolone

Photos of 17-Hydroxypregnenolone

Podcasts & MP3s on 17-Hydroxypregnenolone

Videos on 17-Hydroxypregnenolone

Evidence Based Medicine

Cochrane Collaboration on 17-Hydroxypregnenolone

Bandolier on 17-Hydroxypregnenolone

TRIP on 17-Hydroxypregnenolone

Clinical Trials

Ongoing Trials on 17-Hydroxypregnenolone at Clinical Trials.gov

Trial results on 17-Hydroxypregnenolone

Clinical Trials on 17-Hydroxypregnenolone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on 17-Hydroxypregnenolone

NICE Guidance on 17-Hydroxypregnenolone


FDA on 17-Hydroxypregnenolone

CDC on 17-Hydroxypregnenolone


Books on 17-Hydroxypregnenolone


17-Hydroxypregnenolone in the news

Be alerted to news on 17-Hydroxypregnenolone

News trends on 17-Hydroxypregnenolone


Blogs on 17-Hydroxypregnenolone


Definitions of 17-Hydroxypregnenolone

Patient Resources / Community

Patient resources on 17-Hydroxypregnenolone

Discussion groups on 17-Hydroxypregnenolone

Patient Handouts on 17-Hydroxypregnenolone

Directions to Hospitals Treating 17-Hydroxypregnenolone

Risk calculators and risk factors for 17-Hydroxypregnenolone

Healthcare Provider Resources

Symptoms of 17-Hydroxypregnenolone

Causes & Risk Factors for 17-Hydroxypregnenolone

Diagnostic studies for 17-Hydroxypregnenolone

Treatment of 17-Hydroxypregnenolone

Continuing Medical Education (CME)

CME Programs on 17-Hydroxypregnenolone


17-Hydroxypregnenolone en Espanol

17-Hydroxypregnenolone en Francais


17-Hydroxypregnenolone in the Marketplace

Patents on 17-Hydroxypregnenolone

Experimental / Informatics

List of terms related to 17-Hydroxypregnenolone


17-Hydroxypregnenolone (also 17-OH-pregnenolone and 17α-hydroxypregnenolone), is a C21 steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty and then decline.[1] High levels are also achieved during pregnancy.


17-OH-pregnenolone is considered a prohormone in the formation of dehydroepiandrosterone (DHEA), itself a prohomone of the sex steroids.

This conversion is mediated by the enzyme 17,20 lyase . As such 17-OH-pregenolone represents an intermediary in the delta-5-pathway that leads from pregnenolone to DHEA. 17-hydroxypregneolone is also converted to 17-hydroxyprogesterone, a prohomone for glucocorticosteroids and androstenedione through the activity of 3-hydroxysteroid dehydrogenase.


There is some evidence that 17-OH-pregnenolone may have activity as a neurohormone.[2]

Clinical use

Measurements of 17-OH-pregnenolone are useful in the diagnosis of certain forms of congenital adrenal hyperplasia.[3] In patients with congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency 17-OH-pregnenolone is increased, while in patients with congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency levels are low to absent.

See also

Congenital adrenal hyperplasia

Additional images


  1. Hill M, Lukac D, Lapcik O, Sulcova J, Hampl R, Pouzar V, Starka L. Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects. Clin Chem Lab Med. 1999 Apr;37(4):439-47. PMID 10369116
  2. Matsunaga M, Ukena K, Baulieu EE, Tsutsui K 7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system. Proc Natl Acad Sci USA 2004 Dec 7;101(49):17282-7. PMID 15569930
  3. Riepe FG, Mahler P, Sippell, Partsch CJ. Longitudinal Study of Plasma Pregnenolone and 17-Hydroxypregnenolone in Full-Term and Preterm Neonates at Birth and during the Early Neonatal Period. The Journal of Clinical Endocrinology & Metabolism (2002) 87: 4301-4306 [1]

Template:WikiDoc Sources