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{{distinguish2|XXY ([[Klinefelter's syndrome]])}}
{{Infobox_Disease |
{{Infobox_Disease |
  Image          = Chromosome Y.svg |
  Caption        = [[Y chromosome]] |
   DiseasesDB    = 33038 |
   DiseasesDB    = 33038 |
   ICD10          = {{ICD10|Q|98|5|q|90}} |
   ICD10          = {{ICD10|Q|98|5|q|90}} |
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   OMIM          = |
   OMIM          = |
   MedlinePlus    = |
   MedlinePlus    = |
  eMedicineSubj  = |
  eMedicineTopic = |
   MeshID        = D014997 |
   MeshID        = D014997 |
}}
}}
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{{CMG}}
{{CMG}}


{{Editor Help}}
 


==Overview==
==Overview==


{{distinguish2|XXY ([[Klinefelter's syndrome]])}}
'''XYY syndrome''' is an [[aneuploidy]] of the [[sex chromosome]]s in which a [[human]] [[male]] receives an extra [[Y chromosome]],producing a '''47,XYY''' [[karyotype]].  
'''XYY syndrome''' is an [[aneuploidy]] of the [[sex chromosome]]s in which a [[human]] [[male]] receives an extra [[Y chromosome]],producing a '''47,XYY''' [[karyotype]].  


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|url=http://www.genetic.org/knowledge/support/store/C210/#Genetics |publisher=KS&A}}</ref>
|url=http://www.genetic.org/knowledge/support/store/C210/#Genetics |publisher=KS&A}}</ref>


==Physical traits==
==Etiology==
Most often, the extra Y chromosome causes no unusual physical features or medical problems. 47,XYY boys have an increased growth velocity during earliest childhood, with an average final height approximately 7 cm above expected final height.<ref name=nielsen>{{cite web |author=Nielsen, Johannes |year=1998 |title=How is height growth? |url=http://www.aaa.dk/TURNER/ENGELSK/XYY.HTM#height |work=XYY Males. An Orientation  |publisher=The Turner Center, [[Aarhus]] Psychiatric Hospital, [[Risskov]], [[Denmark]] |accessdate=2008-01-11}}</ref> Severe [[Acne vulgaris|acne]] was noted in a very few early case reports, but dermatologists specializing in acne now doubt the existence of a relationship with 47,XYY.<ref name=plewig>{{cite book |author=Plewig, Gerd; Kligman, Albert M. |year=2000 |title=Acne and Rosacea |edition=3rd |pages=377 |location=Philadelphia |publisher=Springer-Verlag |isbn=3-540-66751-2}}</ref>
 
[[Testosterone]] levels (prenatally and postnatally) are normal in 47,XYY males.<ref name=ratcliffe>{{cite journal |author=Ratcliffe SG, Read G, Pan H, Fear C, Lindenbaum R, Crossley J |year=1994 |title=Prenatal testosterone levels in XXY and XYY males |journal=Horm Res |volume=42 |issue=3 |pages=106–9 |pmid=7995613 |quotes=no}}</ref> Most 47,XYY males have normal sexual development and usually have normal fertility. Since XYY is not characterized by distinct physical features, the condition is usually detected only during genetic analysis for another reason.
 
==Behavioral characteristics==
47,XYY boys have an increased risk of [[learning difficulties]] (in up to 50%) and delayed speech and language skills.<ref name=allanson/><ref name=guys>{{cite web |author=Guy's Hospital Clinical Genetics Department |title=The XYY Condition |year=2001 |url=http://www.guysandstthomas.nhs.uk/resources/patientinfo/genetics/genetics/xyyparen.pdf |accessdate=2008-12-16}}</ref><ref name=gardner>{{cite book |author=Gardner, R.J. McKinlay; Sutherland, Grant R. |year=2004 |title=Chromosome Abnormalities and Genetic Counseling |edition=3rd |pages=29–30, 42, 199, 207, 257, 263, 393, 424–430 |location=Oxford |publisher=Oxford University Press |isbn=0-19-514960-2}}</ref><ref name=milunsky>{{cite book |author=Milunsky, Jeff M. |year=2004 |chapter=Prenatal Diagnosis of Sex Chromosome Abnormalities |editor=in Milunsky, Aubrey (ed.) |title=Genetic Disorders and the Fetus : Diagnosis, Prevention, and Treatment |edition=5th |pages=297–340 |location=Baltimore |publisher=The Johns Hopkins University Press |isbn=0-8018-7928-0 |quotes=no}}</ref><ref name=nussbaum>{{cite book |author=Nussbaum, Robert L.; McInnes, Roderick R.; Willard, Huntington F. |year=2004 |title=Thompson & Thompson Genetics in Medicine, Revised Reprint |edition=6th |pages=172–174 |location=Philadelphia |publisher=W.B. Saunders |isbn=0-7216-0244-4}}</ref><ref name=beltz>{{cite book |author=Beltz, Carin Lea |year=2005 |chapter=XYY Syndrome |editor=in Narins, Brigham (ed.) |title=The Gale Encyclopedia of Genetic Disorders |edition=2nd |pages=1369–1371 |location=Detroit |publisher=Thomson Gale |isbn=1-4144-0365-8 |quotes=no}}</ref><ref name=firth>{{cite book |author=Firth, Helen V.; Hurst, Jane A.; Hall, Judith G. |year=2005 |title=Oxford Desk Reference: Clinical genetics |pages=498–499 |location=Oxford |publisher=Oxford University Press |isbn=0-19-262896-8}}</ref><ref name=ghr>{{cite web |author=National Library of Medicine |title=Genetics Home Reference: 47,XYY syndrome |year=2006 |url=http://ghr.nlm.nih.gov/condition=47xyysyndrome |accessdate=2006-08-28}}</ref>  In contrast, a national survey of US children conducted in 2004 for the [[Centers for Disease Control and Prevention|CDC]] found that 10% of 46,XY boys had a learning disability.<ref name=bloom>{{cite journal |author=Bloom B, Dey AN |year=2006 |publisher=National Center for Health Statistics |title=Summary health statistics for U.S. children: National Health Interview Survey, 2004 | journal=Vital Health Stat |volume=10 |issue=227 |url=http://www.cdc.gov/nchs/data/series/sr_10/sr10_227.pdf |pages=1–85 |pmid=16532761 |quotes=no}}</ref>
 
As with [[Klinefelter's syndrome|47,XXY]] boys and [[Triple X syndrome|47,XXX]] girls, [[IQ]] scores of 47,XYY boys average 10–15 points below their siblings.<ref name=guys/><ref name=milunsky/><ref name=nussbaum/><ref name=firth/> It is important to realize that this amount of variation — an average difference of 12 IQ points — occurs naturally between children in the same family.<ref name=guys/> In 14 prenatally diagnosed 47,XYY boys from high socioeconomic status families, IQ scores available for 6 boys ranged from 100–147 with a mean of 120. For 11 boys with siblings, in 9 instances their siblings were stronger academically, but in one case they were performing equal to and in another case superior to their brothers and sisters.<ref name=linden>{{cite journal |author=Linden MG, Bender BG |year=2002 |title=Fifty-one prenatally diagnosed children and adolescents with sex chromosome abnormalities |journal=Am J Med Genet |volume=110 |issue=1 |pagse=11-8 |pmid=12116265 |quotes=no |doi=10.1002/ajmg.10394 |pages=11}}</ref>
 
Developmental delays and behavioral problems are also possible, but these characteristics vary widely among affected boys and men, are not unique to 47,XYY and are managed no differently than in 46,XY males.<ref name=milunsky/><ref name=ghr/> Aggression is not seen more frequently in 47,XYY males.<ref name=allanson/><ref name=guys/><ref name=milunsky/><ref name=nussbaum/><ref name=beltz/>
 
==Cause==
47,XYY is not inherited, but usually occurs as a random event during the formation of [[Spermatozoon|sperm]] cells. An error in chromosome separation during metaphase II (of [[meiosis#meiosis II|meiosis II]]) called [[nondisjunction]] can result in sperm cells with an extra copy of the Y chromosome. If one of these atypical sperm cells contributes to the genetic makeup of a child, the child will have an extra Y chromosome in each of the body's cells.<ref name=ghr/><ref name=robinson>{{cite journal |author=Robinson DO, Jacobs PA |year=1999 |title=The origin of the extra Y chromosome in males with a 47,XYY karyotype |journal=Hum Mol Genet |volume=8 |issue=12 |pages=2205–9 |pmid=10545600 |url=http://hmg.oxfordjournals.org/cgi/content/full/8/12/2205 |quotes=no |doi=10.1093/hmg/8.12.2205}}</ref>
47,XYY is not inherited, but usually occurs as a random event during the formation of [[Spermatozoon|sperm]] cells. An error in chromosome separation during metaphase II (of [[meiosis#meiosis II|meiosis II]]) called [[nondisjunction]] can result in sperm cells with an extra copy of the Y chromosome. If one of these atypical sperm cells contributes to the genetic makeup of a child, the child will have an extra Y chromosome in each of the body's cells.<ref name=ghr/><ref name=robinson>{{cite journal |author=Robinson DO, Jacobs PA |year=1999 |title=The origin of the extra Y chromosome in males with a 47,XYY karyotype |journal=Hum Mol Genet |volume=8 |issue=12 |pages=2205–9 |pmid=10545600 |url=http://hmg.oxfordjournals.org/cgi/content/full/8/12/2205 |quotes=no |doi=10.1093/hmg/8.12.2205}}</ref>


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Four months later, in April 1970, Peter L. Pearson and Martin Bobrow at the [[Medical Research Council (UK)|MRC]] Population Genetics Unit in Oxford and Canino G. Vosa at the [[University of Oxford]] reported fluorescent  "male" sex chromatin bodies in the nuclei of interphase cells in buccal smears treated with quinacrine dihdyrochloride.<!--
Four months later, in April 1970, Peter L. Pearson and Martin Bobrow at the [[Medical Research Council (UK)|MRC]] Population Genetics Unit in Oxford and Canino G. Vosa at the [[University of Oxford]] reported fluorescent  "male" sex chromatin bodies in the nuclei of interphase cells in buccal smears treated with quinacrine dihdyrochloride.<!--
   --><ref name="pearson 1970">{{cite journal |author=Pearson PL, Bobrow M, Vosa CG |month=April 4, |year=1970 |title=Technique for Identifying ''Y'' Chromosomes in Human Interphase Nuclei |journal=[[Nature (journal)|Nature]] |volume=226 |issue=5240 |pages=78–80 |url=http://www.nature.com/nature/journal/v226/n5240/abs/226078a0.html |pmid=4190810 |doi=10.1038/226078a0}}</ref>
   --><ref name="pearson 1970">{{cite journal |author=Pearson PL, Bobrow M, Vosa CG |month=April 4, |year=1970 |title=Technique for Identifying ''Y'' Chromosomes in Human Interphase Nuclei |journal=[[Nature (journal)|Nature]] |volume=226 |issue=5240 |pages=78–80 |url=http://www.nature.com/nature/journal/v226/n5240/abs/226078a0.html |pmid=4190810 |doi=10.1038/226078a0}}</ref>
==Physical traits==
Most often, the extra Y chromosome causes no unusual physical features or medical problems. 47,XYY boys have an increased growth velocity during earliest childhood, with an average final height approximately 7 cm above expected final height.<ref name=nielsen>{{cite web |author=Nielsen, Johannes |year=1998 |title=How is height growth? |url=http://www.aaa.dk/TURNER/ENGELSK/XYY.HTM#height |work=XYY Males. An Orientation  |publisher=The Turner Center, Aarhus Psychiatric Hospital, Risskov, Denmark |accessdate=2008-01-11}}</ref> Severe [[Acne vulgaris|acne]] was noted in a very few early case reports, but dermatologists specializing in acne now doubt the existence of a relationship with 47,XYY.<ref name=plewig>{{cite book |author=Plewig, Gerd; Kligman, Albert M. |year=2000 |title=Acne and Rosacea |edition=3rd |pages=377 |location=Philadelphia |publisher=Springer-Verlag |isbn=3-540-66751-2}}</ref>
[[Testosterone]] levels (prenatally and postnatally) are normal in 47,XYY males.<ref name=ratcliffe>{{cite journal |author=Ratcliffe SG, Read G, Pan H, Fear C, Lindenbaum R, Crossley J |year=1994 |title=Prenatal testosterone levels in XXY and XYY males |journal=Horm Res |volume=42 |issue=3 |pages=106–9 |pmid=7995613 |quotes=no}}</ref> Most 47,XYY males have normal sexual development and usually have normal fertility. Since XYY is not characterized by distinct physical features, the condition is usually detected only during genetic analysis for another reason.
==Behavioral characteristics==
47,XYY boys have an increased risk of [[learning difficulties]] (in up to 50%) and delayed speech and language skills.<ref name=allanson/><ref name=guys>{{cite web |author=Guy's Hospital Clinical Genetics Department |title=The XYY Condition |year=2001 |url=http://www.guysandstthomas.nhs.uk/resources/patientinfo/genetics/genetics/xyyparen.pdf |accessdate=2008-12-16}}</ref><ref name=gardner>{{cite book |author=Gardner, R.J. McKinlay; Sutherland, Grant R. |year=2004 |title=Chromosome Abnormalities and Genetic Counseling |edition=3rd |pages=29–30, 42, 199, 207, 257, 263, 393, 424–430 |location=Oxford |publisher=Oxford University Press |isbn=0-19-514960-2}}</ref><ref name=milunsky>{{cite book |author=Milunsky, Jeff M. |year=2004 |chapter=Prenatal Diagnosis of Sex Chromosome Abnormalities |editor=in Milunsky, Aubrey (ed.) |title=Genetic Disorders and the Fetus : Diagnosis, Prevention, and Treatment |edition=5th |pages=297–340 |location=Baltimore |publisher=The Johns Hopkins University Press |isbn=0-8018-7928-0 |quotes=no}}</ref><ref name=nussbaum>{{cite book |author=Nussbaum, Robert L.; McInnes, Roderick R.; Willard, Huntington F. |year=2004 |title=Thompson & Thompson Genetics in Medicine, Revised Reprint |edition=6th |pages=172–174 |location=Philadelphia |publisher=W.B. Saunders |isbn=0-7216-0244-4}}</ref><ref name=beltz>{{cite book |author=Beltz, Carin Lea |year=2005 |chapter=XYY Syndrome |editor=in Narins, Brigham (ed.) |title=The Gale Encyclopedia of Genetic Disorders |edition=2nd |pages=1369–1371 |location=Detroit |publisher=Thomson Gale |isbn=1-4144-0365-8 |quotes=no}}</ref><ref name=firth>{{cite book |author=Firth, Helen V.; Hurst, Jane A.; Hall, Judith G. |year=2005 |title=Oxford Desk Reference: Clinical genetics |pages=498–499 |location=Oxford |publisher=Oxford University Press |isbn=0-19-262896-8}}</ref><ref name=ghr>{{cite web |author=National Library of Medicine |title=Genetics Home Reference: 47,XYY syndrome |year=2006 |url=http://ghr.nlm.nih.gov/condition=47xyysyndrome |accessdate=2006-08-28}}</ref>  In contrast, a national survey of US children conducted in 2004 for the [[Centers for Disease Control and Prevention|CDC]] found that 10% of 46,XY boys had a learning disability.<ref name=bloom>{{cite journal |author=Bloom B, Dey AN |year=2006 |publisher=National Center for Health Statistics |title=Summary health statistics for U.S. children: National Health Interview Survey, 2004 | journal=Vital Health Stat |volume=10 |issue=227 |url=http://www.cdc.gov/nchs/data/series/sr_10/sr10_227.pdf |pages=1–85 |pmid=16532761 |quotes=no}}</ref>
As with [[Klinefelter's syndrome|47,XXY]] boys and [[Triple X syndrome|47,XXX]] girls, [[IQ]] scores of 47,XYY boys average 10–15 points below their siblings.<ref name=guys/><ref name=milunsky/><ref name=nussbaum/><ref name=firth/> It is important to realize that this amount of variation — an average difference of 12 IQ points — occurs naturally between children in the same family.<ref name=guys/> In 14 prenatally diagnosed 47,XYY boys from high socioeconomic status families, IQ scores available for 6 boys ranged from 100–147 with a mean of 120. For 11 boys with siblings, in 9 instances their siblings were stronger academically, but in one case they were performing equal to and in another case superior to their brothers and sisters.<ref name=linden>{{cite journal |author=Linden MG, Bender BG |year=2002 |title=Fifty-one prenatally diagnosed children and adolescents with sex chromosome abnormalities |journal=Am J Med Genet |volume=110 |issue=1 |pagse=11-8 |pmid=12116265 |quotes=no |doi=10.1002/ajmg.10394 |pages=11}}</ref>
Developmental delays and behavioral problems are also possible, but these characteristics vary widely among affected boys and men, are not unique to 47,XYY and are managed no differently than in 46,XY males.<ref name=milunsky/><ref name=ghr/> Aggression is not seen more frequently in 47,XYY males.<ref name=allanson/><ref name=guys/><ref name=milunsky/><ref name=nussbaum/><ref name=beltz/>


==See also==  
==See also==  
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{{reflist|2}}
{{reflist|2}}


==External links==
{{Chromosomal abnormalities}}
* [[Guy's Hospital]] Clinical Genetics Department (2001). [http://www.guysandstthomas.nhs.uk/resources/patientinfo/genetics/genetics/xyyparen.pdf The XYY Condition]
   


* Nielsen, Johannes (1998). [http://www.aaa.dk/TURNER/ENGELSK/XYY.HTM XYY Males. An Orientation]. The Turner Center, [[Aarhus]] Psychiatric Hospital, [[Risskov]], [[Denmark]].
{{WikiDoc Help Menu}}
** XYY information booklet by Dr. Nielsen, a psychiatrist and geneticist who led the longest running of 8 international newborn screening studies of sex chromosome abnormalities.
{{WikiDoc Sources}}


* Unique (http://www.rarechromo.org)
[[Category:Disease]]
** has XYY information leaflets available to members and available for purchase to non-members
 
* Klinefelter Syndrome & Associates (http://www.genetic.org)
** has ''2006 Trisomy X and XYY National Conference'' binders and DVDs available for purchase
 
 
 
{{Chromosomal abnormalities}}
[[Category:Genetic disorders]]
[[Category:Genetic disorders]]
{{SIB}}   
[[Category:Genetics]]
[[Category:Syndromes]]
[[Category:Syndromes]]
 
[[Category:Needs patient information]]
[[ar:متلازمة XYY]]
[[Category:Mature chapter]]
[[bg:XYY синдром]]
[[cs:XYY syndrom]]
[[de:XYY-Syndrom]]
[[es:Síndrome del XYY]]
[[fr:Syndrome 47,XYY]]
[[it:Sindrome 47,XYY]]
[[hu:XYY-szindróma]]
[[nl:XYY-syndroom]]
[[ja:XYY症候群]]
[[no:XYY-syndrom]]
[[pl:Zespół XYY]]
[[pt:Síndrome XYY]]
[[fi:XYY-syndrooma]]
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Latest revision as of 17:32, 20 August 2012

XYY syndrome
ICD-10 Q98.5
ICD-9 758.8
DiseasesDB 33038
MeSH D014997

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Template:Distinguish2 XYY syndrome is an aneuploidy of the sex chromosomes in which a human male receives an extra Y chromosome,producing a 47,XYY karyotype.

Some medical geneticists question whether the term "syndrome" is appropriate for this condition because its phenotype is normal and the vast majority (an estimated 97% in the UK) of 47,XYY males do not know their karyotype.[1][2]

Etiology

47,XYY is not inherited, but usually occurs as a random event during the formation of sperm cells. An error in chromosome separation during metaphase II (of meiosis II) called nondisjunction can result in sperm cells with an extra copy of the Y chromosome. If one of these atypical sperm cells contributes to the genetic makeup of a child, the child will have an extra Y chromosome in each of the body's cells.[3][4]

In some cases, the addition of an extra Y chromosome results from nondisjunction during cell division during a post-zygotic mitosis in early embryonic development. This can produce 46,XY/47,XYY mosaics.[3][4]

Incidence

About 1 in 1,000 boys are born with a 47,XYY karyotype. The incidence of 47,XYY is not affected by advanced paternal or maternal age.[1][5][6]

First case

The first published report of a man with a 47,XYY karyotype was by Avery A. Sandberg and colleagues at Roswell Park Memorial Institute in Buffalo, New York in 1961. It was an incidental finding in a normal 44-year-old, 6 ft. [183 cm] tall man of average intelligence who was karyotyped because he had a daughter with Down syndrome.[7][8]

47,XYY was the last of the common sex chromosome aneuploidies to be discovered, two years after the discoveries of 47,XXY, 45,X, and 47,XXX in 1959. Even the much less common 48,XXYY had been discovered in 1960, a year before 47,XYY. Screening for these X chromosome aneuploidies was possible by noting the presence or absence of "female" sex chromatin bodies (Barr bodies) in the nuclei of interphase cells in buccal smears, a technique developed a decade before the first reported sex chromosome aneuploidy.[9]

An analogous technique to screen for Y chromosome aneuploidies by noting supernumerary "male" sex chromatin bodies was not developed until 1970, a decade after the first reported sex chromosome aneuploidy.[10][11] In December 1969, Lore Zech at the Karolinska Institute in Stockholm first reported intense fluorescence of the AT-rich distal half of the long arm of the Y chromosome in the nuclei of metaphase cells treated with quinacrine mustard.[12] Four months later, in April 1970, Peter L. Pearson and Martin Bobrow at the MRC Population Genetics Unit in Oxford and Canino G. Vosa at the University of Oxford reported fluorescent "male" sex chromatin bodies in the nuclei of interphase cells in buccal smears treated with quinacrine dihdyrochloride.[13]

Physical traits

Most often, the extra Y chromosome causes no unusual physical features or medical problems. 47,XYY boys have an increased growth velocity during earliest childhood, with an average final height approximately 7 cm above expected final height.[14] Severe acne was noted in a very few early case reports, but dermatologists specializing in acne now doubt the existence of a relationship with 47,XYY.[15]

Testosterone levels (prenatally and postnatally) are normal in 47,XYY males.[16] Most 47,XYY males have normal sexual development and usually have normal fertility. Since XYY is not characterized by distinct physical features, the condition is usually detected only during genetic analysis for another reason.

Behavioral characteristics

47,XYY boys have an increased risk of learning difficulties (in up to 50%) and delayed speech and language skills.[1][17][18][5][19][20][6][3] In contrast, a national survey of US children conducted in 2004 for the CDC found that 10% of 46,XY boys had a learning disability.[21]

As with 47,XXY boys and 47,XXX girls, IQ scores of 47,XYY boys average 10–15 points below their siblings.[17][5][19][6] It is important to realize that this amount of variation — an average difference of 12 IQ points — occurs naturally between children in the same family.[17] In 14 prenatally diagnosed 47,XYY boys from high socioeconomic status families, IQ scores available for 6 boys ranged from 100–147 with a mean of 120. For 11 boys with siblings, in 9 instances their siblings were stronger academically, but in one case they were performing equal to and in another case superior to their brothers and sisters.[22]

Developmental delays and behavioral problems are also possible, but these characteristics vary widely among affected boys and men, are not unique to 47,XYY and are managed no differently than in 46,XY males.[5][3] Aggression is not seen more frequently in 47,XYY males.[1][17][5][19][20]

See also

References

  1. 1.0 1.1 1.2 1.3 Graham, Gail E.; Allanson, Judith E.; Gerritsen, Jennifer A. (2007). "Sex chromosome abnormalities". In Rimoin, David L.; Connor, J. Michael.; Pyeritz, Reed E.; Korf, Bruce R. (eds.). Emery and Rimoin's Principles and Practice of Medical Genetics (5th ed.). Philadelphia: Churchill Livingstone Elsevier. pp. 1038–1057. ISBN 0-443-06870-4.
  2. Jacobs, Patricia (2006). "The genetics of XXY, Trisomy X and XYY syndromes: an overview". National Conference on Trisomy X and XYY, UC Davis M.I.N.D. Institute,. DVD 02. Sacramento: KS&A. Unknown parameter |month= ignored (help)
  3. 3.0 3.1 3.2 3.3 National Library of Medicine (2006). "Genetics Home Reference: 47,XYY syndrome". Retrieved 2006-08-28.
  4. 4.0 4.1 Robinson DO, Jacobs PA (1999). "The origin of the extra Y chromosome in males with a 47,XYY karyotype". Hum Mol Genet. 8 (12): 2205–9. doi:10.1093/hmg/8.12.2205. PMID 10545600. Unknown parameter |quotes= ignored (help)
  5. 5.0 5.1 5.2 5.3 5.4 Milunsky, Jeff M. (2004). "Prenatal Diagnosis of Sex Chromosome Abnormalities". In in Milunsky, Aubrey (ed.). Genetic Disorders and the Fetus : Diagnosis, Prevention, and Treatment (5th ed.). Baltimore: The Johns Hopkins University Press. pp. 297–340. ISBN 0-8018-7928-0. Unknown parameter |quotes= ignored (help)
  6. 6.0 6.1 6.2 Firth, Helen V.; Hurst, Jane A.; Hall, Judith G. (2005). Oxford Desk Reference: Clinical genetics. Oxford: Oxford University Press. pp. 498–499. ISBN 0-19-262896-8.
  7. Sandberg AA, Koepf GF, Ishihara T, Hauschka TS (1961). "An XYY human male". Lancet. 278 (7200): 488–9. doi:10.1016/S0140-6736(61)92459-X. PMID 13746118. Unknown parameter |month= ignored (help)
  8. Hauschka TS, Hasson JE, Goldstein MN, Koepf GF, Sandberg AA (1962). "An XYY man with progeny indicating familial tendency to non-disjunction". Am J Hum Genet. 14: 22–30. PMID 13905424. Unknown parameter |month= ignored (help)
  9. Barr ML, Bertram EG (1949). "A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein Synthesis". Nature. 163 (4148): 676–7. doi:10.1038/163676a0.
  10. "In Pursuit of the Y Chromosome". Nature. 226 (5249): 897. 1970. doi:10.1038/226897a0. Unknown parameter |month= ignored (help)
  11. "Dyeing the Y Chromosome". Lancet. 297 (7693): 275–6. 1971. doi:10.1016/S0140-6736(71)91008-7. Unknown parameter |month= ignored (help)
  12. Zech L (1969). "Investigation of Metaphase Chromosomes with DNA-binding Flurochromes". Exp Cell Res. 58 (2–3): 463. Unknown parameter |month= ignored (help)
  13. Pearson PL, Bobrow M, Vosa CG (1970). "Technique for Identifying Y Chromosomes in Human Interphase Nuclei". Nature. 226 (5240): 78–80. doi:10.1038/226078a0. PMID 4190810. Unknown parameter |month= ignored (help)
  14. Nielsen, Johannes (1998). "How is height growth?". XYY Males. An Orientation. The Turner Center, Aarhus Psychiatric Hospital, Risskov, Denmark. Retrieved 2008-01-11.
  15. Plewig, Gerd; Kligman, Albert M. (2000). Acne and Rosacea (3rd ed.). Philadelphia: Springer-Verlag. p. 377. ISBN 3-540-66751-2.
  16. Ratcliffe SG, Read G, Pan H, Fear C, Lindenbaum R, Crossley J (1994). "Prenatal testosterone levels in XXY and XYY males". Horm Res. 42 (3): 106–9. PMID 7995613. Unknown parameter |quotes= ignored (help)
  17. 17.0 17.1 17.2 17.3 Guy's Hospital Clinical Genetics Department (2001). "The XYY Condition" (PDF). Retrieved 2008-12-16.
  18. Gardner, R.J. McKinlay; Sutherland, Grant R. (2004). Chromosome Abnormalities and Genetic Counseling (3rd ed.). Oxford: Oxford University Press. pp. 29–30, 42, 199, 207, 257, 263, 393, 424–430. ISBN 0-19-514960-2.
  19. 19.0 19.1 19.2 Nussbaum, Robert L.; McInnes, Roderick R.; Willard, Huntington F. (2004). Thompson & Thompson Genetics in Medicine, Revised Reprint (6th ed.). Philadelphia: W.B. Saunders. pp. 172–174. ISBN 0-7216-0244-4.
  20. 20.0 20.1 Beltz, Carin Lea (2005). "XYY Syndrome". In in Narins, Brigham (ed.). The Gale Encyclopedia of Genetic Disorders (2nd ed.). Detroit: Thomson Gale. pp. 1369–1371. ISBN 1-4144-0365-8. Unknown parameter |quotes= ignored (help)
  21. Bloom B, Dey AN (2006). "Summary health statistics for U.S. children: National Health Interview Survey, 2004" (PDF). Vital Health Stat. National Center for Health Statistics. 10 (227): 1–85. PMID 16532761. Unknown parameter |quotes= ignored (help)
  22. Linden MG, Bender BG (2002). "Fifty-one prenatally diagnosed children and adolescents with sex chromosome abnormalities". Am J Med Genet. 110 (1): 11. doi:10.1002/ajmg.10394. PMID 12116265. Unknown parameter |quotes= ignored (help); Unknown parameter |pagse= ignored (help)

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