- For the similarly-spelled vitamin compound, see Thiamine
3D model (JSmol)
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|Molar mass||126.11334 g/mol|
|Except where noted otherwise, data are given for|
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Thymine is one of the four bases in the nucleic acid of DNA that make up the letters ATGC. The others are adenine, guanine, and cytosine. Thymine (T) always pairs with adenine. Also known as 5-methyluracil a pyrimidine nucleobase. As the name implies, thymine may be derived by methylation of uracil at the 5th carbon. In RNA thymine is replaced with uracil in most cases. In DNA, thymine(T) binds to adenine (A) via two hydrogen bonds to assist in stabilizing the nucleic acid structures.
Thymine combined with deoxyribose creates the nucleoside deoxythymidine, which is synonymous with the term thymidine. Thymidine can be phosphorylated with one, two or three phosphoric acid groups, creating respectively TMP, TDP or TTP (thymidine mono- di- or triphosphate).
One of the common mutations of DNA involves two adjacent thymines or cytosine, which in presence of ultraviolet light may form thymine dimers, causing "kinks" in the DNA molecule that inhibit normal function.
Thymine could also be a target for actions of 5-fu in cancer treatment. 5-fu can be a metabolic analog of Thymine (in DNA synthesis) or Uracil (in RNA synthesis). Substitution of this analog inhibit DNA synthesis in actively dividing cells.
ar:ثايمين ca:Timina cs:Thymin da:Thymin de:Thymin el:Θυμίνη eo:Timino id:Timin it:Timina he:תימין lt:Timinas hu:Timin nl:Thymine simple:Thymine sl:Timin sr:Тимин sh:Timin fi:Tymiini sv:Tymin th:ไทมีน uk:Тимін