VAMP1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Vesicle-associated membrane protein 1''' is a [[protein]] that in humans is encoded by the ''VAMP1'' [[gene]].<ref name="pmid1976629">{{cite journal | vauthors = Archer BT, Ozçelik T, Jahn R, Francke U, Südhof TC | title = Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2 | journal = The Journal of Biological Chemistry | volume = 265 | issue = 28 | pages = 17267–73 | date = October 1990 | pmid = 1976629 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6843| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_VAMP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kil.
| PDB = {{PDB2|1kil}}, {{PDB2|1n7s}}
| Name = Vesicle-associated membrane protein 1 (synaptobrevin 1)
| HGNCid = 12642
| Symbol = VAMP1
| AltSymbols =; DKFZp686H12131; SYB1; VAMP-1
| OMIM = 185880
| ECnumber = 
| Homologene = 40678
| MGIid = 1313276
| GeneAtlas_image1 = PBB_GE_VAMP1_207101_at_tn.png
| GeneAtlas_image2 = PBB_GE_VAMP1_213326_at_tn.png
| GeneAtlas_image3 = PBB_GE_VAMP1_207100_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6843
    | Hs_Ensembl = ENSG00000139190
    | Hs_RefseqProtein = NP_055046
    | Hs_RefseqmRNA = NM_014231
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 6440603
    | Hs_GenLoc_end = 6450326
    | Hs_Uniprot = P23763
    | Mm_EntrezGene = 22317
    | Mm_Ensembl = ENSMUSG00000030337
    | Mm_RefseqmRNA = NM_001080557
    | Mm_RefseqProtein = NP_001074026
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 125181200
    | Mm_GenLoc_end = 125206163
    | Mm_Uniprot = Q62442
  }}
}}
'''Vesicle-associated membrane protein 1 (synaptobrevin 1)''', also known as '''VAMP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6843| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Synaptobrevin]]s/VAMPs, [[syntaxin]]s, and the 25-kD synaptosomal-associated protein [[SNAP25]] are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple [[alternative splicing|alternative splice]] variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.<ref name="entrez" />  
{{PBB_Summary
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.<ref name="entrez">{{cite web | title = Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6843| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Homozygous mutations in VAMP1 have been identified in a series of children affected with a form of [[congenital myasthenic syndrome]] and similar presynaptic features in these patients  and the [[knock-out mouse|knock-out]] VAMP1 mouse have been demonstrated.<ref>{{cite journal | vauthors = Salpietro V, Lin W, Delle Vedove A, Storbeck M, Liu Y, Efthymiou S, Manole A, Wiethoff S, Ye Q, Saggar A, McElreavey K, Krishnakumar SS, Pitt M, Bello OD, Rothman JE, Basel-Vanagaite L, Hubshman MW, Aharoni S, Manzur AY, Wirth B, Houlden H | title = Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome | journal = Annals of Neurology | volume = 81 | issue = 4 | pages = 597–603 | date = April 2017 | pmid = 28253535 | pmc = 5413866 | doi = 10.1002/ana.24905 }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== Interactive pathway map ==
| citations =
{{NicotineDopaminergicActivity_WP1602|highlight=Dopamine__alt3}}
*{{cite journal | author=Archer BT, Ozçelik T, Jahn R, ''et al.'' |title=Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17267-73 |year= 1990 |pmid= 1976629 |doi= }}
 
*{{cite journal | author=Ravichandran V, Chawla A, Roche PA |title=Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13300-3 |year= 1996 |pmid= 8663154 |doi= }}
== References ==
*{{cite journal | author=Jagadish MN, Fernandez CS, Hewish DR, ''et al.'' |title=Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. |journal=Biochem. J. |volume=317 ( Pt 3) |issue=  |pages= 945-54 |year= 1996 |pmid= 8760387 |doi= }}
{{reflist}}
*{{cite journal | author=Annaert WG, Becker B, Kistner U, ''et al.'' |title=Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. |journal=J. Cell Biol. |volume=139 |issue= 6 |pages= 1397-410 |year= 1998 |pmid= 9396746 |doi= }}
{{-}}
*{{cite journal | author=Weir ML, Klip A, Trimble WS |title=Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. |journal=Biochem. J. |volume=333 ( Pt 2) |issue=  |pages= 247-51 |year= 1998 |pmid= 9657962 |doi= }}
== Further reading ==
*{{cite journal | author=Isenmann S, Khew-Goodall Y, Gamble J, ''et al.'' |title=A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. |journal=Mol. Biol. Cell |volume=9 |issue= 7 |pages= 1649-60 |year= 1999 |pmid= 9658161 |doi= }}
{{refbegin | 33em}}
*{{cite journal | author=Nishimura Y, Hayashi M, Inada H, Tanaka T |title=Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 1 |pages= 21-6 |year= 1999 |pmid= 9920726 |doi= 10.1006/bbrc.1998.9876 }}
* {{cite journal | vauthors = Ravichandran V, Chawla A, Roche PA | title = Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues | journal = The Journal of Biological Chemistry | volume = 271 | issue = 23 | pages = 13300–3 | date = June 1996 | pmid = 8663154 | doi = 10.1074/jbc.271.23.13300 }}
*{{cite journal | author=Berglund L, Hoffmann HJ, Dahl R, Petersen TE |title=VAMP-1 has a highly variable C-terminus generated by alternative splicing. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 3 |pages= 777-80 |year= 1999 |pmid= 10544008 |doi= 10.1006/bbrc.1999.1588 }}
* {{cite journal | vauthors = Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW | title = Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2 | journal = The Biochemical Journal | volume = 317 ( Pt 3) | issue =  | pages = 945–54 | date = August 1996 | pmid = 8760387 | pmc = 1217577 | doi = 10.1042/bj3170945 | series = 317 }}
*{{cite journal | author=Pérez-Brangulí F, Muhaisen A, Blasi J |title=Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. |journal=Mol. Cell. Neurosci. |volume=20 |issue= 2 |pages= 169-80 |year= 2002 |pmid= 12093152 |doi=  }}
* {{cite journal | vauthors = Annaert WG, Becker B, Kistner U, Reth M, Jahn R | title = Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31 | journal = The Journal of Cell Biology | volume = 139 | issue = 6 | pages = 1397–410 | date = December 1997 | pmid = 9396746 | pmc = 2132629 | doi = 10.1083/jcb.139.6.1397 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Weir ML, Klip A, Trimble WS | title = Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP | journal = The Biochemical Journal | volume = 333 ( Pt 2) | issue =  | pages = 247–51 | date = July 1998 | pmid = 9657962 | pmc = 1219579 | doi = 10.1042/bj3330247 | series = 333 }}
*{{cite journal | author=Imabayashi H, Mori T, Gojo S, ''et al.'' |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35-50 |year= 2003 |pmid= 12878157 |doi= }}
* {{cite journal | vauthors = Isenmann S, Khew-Goodall Y, Gamble J, Vadas M, Wattenberg BW | title = A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal | journal = Molecular Biology of the Cell | volume = 9 | issue = 7 | pages = 1649–60 | date = July 1998 | pmid = 9658161 | pmc = 25402 | doi = 10.1091/mbc.9.7.1649 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Nishimura Y, Hayashi M, Inada H, Tanaka T | title = Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins | journal = Biochemical and Biophysical Research Communications | volume = 254 | issue = 1 | pages = 21–6 | date = January 1999 | pmid = 9920726 | doi = 10.1006/bbrc.1998.9876 }}
}}
* {{cite journal | vauthors = Berglund L, Hoffmann HJ, Dahl R, Petersen TE | title = VAMP-1 has a highly variable C-terminus generated by alternative splicing | journal = Biochemical and Biophysical Research Communications | volume = 264 | issue = 3 | pages = 777–80 | date = November 1999 | pmid = 10544008 | doi = 10.1006/bbrc.1999.1588 }}
* {{cite journal | vauthors = Pérez-Brangulí F, Muhaisen A, Blasi J | title = Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay | journal = Molecular and Cellular Neurosciences | volume = 20 | issue = 2 | pages = 169–80 | date = June 2002 | pmid = 12093152 | doi = 10.1006/mcne.2002.1122 }}
* {{cite journal | vauthors = Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A | title = Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis | journal = Experimental Cell Research | volume = 288 | issue = 1 | pages = 35–50 | date = August 2003 | pmid = 12878157 | doi = 10.1016/S0014-4827(03)00130-7 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6843}}
{{WikiDoc Sources}}
{{Vesicular transport proteins}}
 
{{gene-12-stub}}

Latest revision as of 16:08, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.[1][2]

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.[2]

Clinical significance

Homozygous mutations in VAMP1 have been identified in a series of children affected with a form of congenital myasthenic syndrome and similar presynaptic features in these patients and the knock-out VAMP1 mouse have been demonstrated.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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<imagemap> Image:NicotineDopaminergic_WP1602.png
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

  1. ↑ Archer BT, Ozçelik T, Jahn R, Francke U, Südhof TC (October 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". The Journal of Biological Chemistry. 265 (28): 17267–73. PMID 1976629.
  2. ↑ 2.0 2.1 "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)".
  3. ↑ Salpietro V, Lin W, Delle Vedove A, Storbeck M, Liu Y, Efthymiou S, Manole A, Wiethoff S, Ye Q, Saggar A, McElreavey K, Krishnakumar SS, Pitt M, Bello OD, Rothman JE, Basel-Vanagaite L, Hubshman MW, Aharoni S, Manzur AY, Wirth B, Houlden H (April 2017). "Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome". Annals of Neurology. 81 (4): 597–603. doi:10.1002/ana.24905. PMC 5413866. PMID 28253535.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=VAMP1&oldid=1416118"