AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene .[1] [2]
Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1 ), a medium chain, mu-4 (AP4M1 ), and a small chain, sigma-4 (AP4S1 )[2]
Interactions AP4B1 has been shown to interact with AP4M1 .[3]
Clinical relevance AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[4] [5]
References
↑ Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem . 274 (11): 7278–85. doi :10.1074/jbc.274.11.7278 . PMID 10066790 . ↑ 2.0 2.1 "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit" .↑ Hirst J, Bright NA, Rous B, Robinson MS (August 1999). "Characterization of a fourth adaptor-related protein complex" . Mol. Biol. Cell . 10 (8): 2787–802. doi :10.1091/mbc.10.8.2787 . PMC 25515 PMID 10436028 . ↑ Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L (June 2011). "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature" . Am. J. Hum. Genet . 88 (6): 788–95. doi :10.1016/j.ajhg.2011.04.019 . PMC 3113253 PMID 21620353 . ↑ "Cerebral Palsy Linked to Genetic Abnormalities" . medscape.
External links Further reading
Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex" . Mol. Biol. Cell . 10 (8): 2787–802. doi :10.1091/mbc.10.8.2787 . PMC 25515 PMID 10436028 . Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun . 284 (4): 1083–9. doi :10.1006/bbrc.2001.5081 . PMID 11409905 . Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun . 298 (5): 720–30. doi :10.1016/S0006-291X(02)02522-6 . PMID 12419313 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature . 441 (7091): 315–21. doi :10.1038/nature04727 . PMID 16710414 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
