Toxic shock syndrome diagnostic criteria: Difference between revisions

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== Overview ==
== Overview ==
The diagnostic criteria varies depend on the organism responsible for the Toxic Shock Syndrome (TSS), but mainly the diagnosis of TSS is based on the clinical presentation.  
The diagnostic criteria varies depend on the [[organism]] responsible for the [[Toxic shock syndrome|Toxic Shock Syndrome]] (TSS), but mainly the diagnosis of TSS is based on the clinical presentation.  


==Diagnostic Criteria==
==Diagnostic Criteria==
Line 12: Line 10:


==== Clinical Criteria ====
==== Clinical Criteria ====
The diagnosis of Staphylococcal toxic shock syndrome (TSS) is based upon clinical presentation as no confirmatory diagnostic criteria is developed yet. A criteria list have been established by United States Centers for Disease Control and Prevention ([[Centers for Disease Control and Prevention|CDC]]) for epidemiologic studies on Staphylococcal TSS, mean that a patient can not be excluded from disease based on the absence of one of these criterias when it come to diagnosis terms. This criteria list means that a confirmed case is someone who has fever >38.9°C, [[hypotension]], diffuse [[erythroderma]], [[desquamation]] (unless the patient dies before desquamation can occur), and involvement of at least three organ systems. If a patient misses one of these criterias, the case may be considered as a probable case.<ref name="pmid7289007">{{cite journal |vauthors=Tofte RW, Williams DN |title=Toxic shock syndrome. Evidence of a broad clinical spectrum |journal=JAMA |volume=246 |issue=19 |pages=2163–7 |year=1981 |pmid=7289007 |doi= |url=}}</ref>
The diagnosis of [[Staphylococcus|Staphylococcal]] [[toxic shock syndrome]] (TSS) is based upon clinical presentation as no confirmatory diagnostic criteria is developed yet. A criteria list have been established by United States Centers for Disease Control and Prevention ([[Centers for Disease Control and Prevention|CDC]]) for [[Epidemiology|epidemiologic]] studies on [[Staphylococcus|Staphylococcal]] TSS, mean that a patient can not be excluded from disease based on the absence of one of these criterias when it come to [[diagnosis]] terms. This [[criteria]] list means that a confirmed case is someone who has [[fever]] >38.9°C, [[hypotension]], diffuse [[erythroderma]], [[desquamation]] (unless the patient dies before [[desquamation]] can occur), and involvement of at least three organ systems. If a patient misses one of these criterias, the case may be considered as a probable/susceptible case.<ref name="pmid7289007">{{cite journal |vauthors=Tofte RW, Williams DN |title=Toxic shock syndrome. Evidence of a broad clinical spectrum |journal=JAMA |volume=246 |issue=19 |pages=2163–7 |year=1981 |pmid=7289007 |doi= |url=}}</ref>


An illness with the following clinical manifestations:
An [[illness]] with the following clinical manifestations:
* Fever: temperature greater than or equal to 102.0°F (greater than or equal to 38.9°C)
* [[Fever]]: [[Temperature]] greater than or equal to 102.0°F (greater than or equal to 38.9°C)
* Rash: diffuse macular erythroderma
* [[Rash]]: Diffuse [[macular]] [[erythroderma]]
* Desquamation: 1-2 weeks after onset of rash
* [[Desquamation]]: 1-2 weeks after onset of rash
* Hypotension: systolic blood pressure less than or equal to 90 mm Hg for adults or less than fifth percentile by age for children aged less than 16 years
* [[Hypotension]]: [[Systolic blood pressure]] less than or equal to 90 mm Hg for adults or less than fifth percentile by age for children aged less than 16 years
* Multisystem involvement (three or more of the following organ systems):
* [[Multiorgan failure|Multiorgan involvement]] (three or more of the following organ systems):
** Gastrointestinal: vomiting or diarrhea at onset of illness
** [[Gastrointestinal]]: [[Vomiting]] or [[diarrhea]] at onset of [[illness]]
** Muscular: severe myalgia or creatine phosphokinase level at least twice the upper limit of normal
** [[Muscular]]: Severe myalgia or creatine phosphokinase level at least twice the upper limit of normal
** Mucous membrane: vaginal, oropharyngeal, or conjunctival hyperemia
** [[Mucous membrane]]: [[Vaginal]], [[oropharyngeal]], or [[Conjunctival disease|conjunctival hyperemia]]
** Renal: blood urea nitrogen or creatinine at least twice the upper limit of normal for laboratory or urinary sediment with pyuria (greater than or equal to 5 leukocytes per high-power field) in the absence of urinary tract infection
** [[Kidney|Renal]]: [[Blood urea nitrogen]] or [[creatinine]] at least twice the upper limit of normal for laboratory or urinary sediment with [[pyuria]] (greater than or equal to 5 [[leukocytes]] per high-power field) in the absence of [[urinary tract infection]]
** Hepatic: total bilirubin, alanine aminotransferase enzyme, or asparate aminotransferase enzyme levels at least twice the upper limit of normal for laboratory
** [[Hepatic]]: [[Bilirubin|Total bilirubin]], [[Alanine aminotransferase|alanine]] [[aminotransferase]] enzyme, or [[Aspartate|aspartate aminotransferase]] enzyme levels at least twice the upper limit of normal for laboratory
** Hematologic: platelets less than 100,000/mm3
** [[Hematologic]]: [[Platelets]] less than 100,000/mm3
** Central nervous system: disorientation or alterations in consciousness without focal neurologic signs when fever and hypotension are absent<ref name="pmid2294395"><nowiki>cite journal |vauthors= |title=Repeat injuries in an inner city population--Philadelphia, 1987-1988 |journal=MMWR Morb. Mortal. Wkly. Rep. |volume=39 |issue=1 |pages=1–3 |year=1990 |pmid=2294395 |doi= |url=}}</nowiki></ref><ref name="pmid9148133">{{cite journal |vauthors= |title=Case definitions for infectious conditions under public health surveillance. Centers for Disease Control and Prevention |journal=MMWR Recomm Rep |volume=46 |issue=RR-10 |pages=1–55 |year=1997 |pmid=9148133 |doi= |url=}}</ref>.
** [[Central nervous system]]: [[Disorientation]] or alterations in [[consciousness]] without [[focal neurologic signs]] when [[fever]] and [[hypotension]] are absent<ref name="pmid2294395"><nowiki>cite journal |vauthors= |title=Repeat injuries in an inner city population--Philadelphia, 1987-1988 |journal=MMWR Morb. Mortal. Wkly. Rep. |volume=39 |issue=1 |pages=1–3 |year=1990 |pmid=2294395 |doi= |url=}}</nowiki></ref><ref name="pmid9148133">{{cite journal |vauthors= |title=Case definitions for infectious conditions under public health surveillance. Centers for Disease Control and Prevention |journal=MMWR Recomm Rep |volume=46 |issue=RR-10 |pages=1–55 |year=1997 |pmid=9148133 |doi= |url=}}</ref>.


==== Laboratory Criteria for Diagnosis ====
==== Laboratory Criteria for Diagnosis ====
Negative results on the following tests, if obtained:
Negative results on the following tests, if obtained:
* Blood or cerebrospinal fluid cultures blood culture may be positive for ''Staphylococcus aureus'')
* [[Blood]] or [[cerebrospinal fluid]] cultures. Blood culture may be positive for [[Staphylococcus aureus]].
* Negative serologies for Rocky Mountain spotted fever, leptospirosis, or measles
* Negative [[Serology|serologies]] for [[Rocky Mountain spotted fever]], [[leptospirosis]], or [[measles]]<ref name="urlToxic Shock Syndrome (Other Than Streptococcal) | 2011 Case Definition">{{cite web |url=https://wwwn.cdc.gov/nndss/conditions/toxic-shock-syndrome-other-than-streptococcal/case-definition/2011/ |title=Toxic Shock Syndrome (Other Than Streptococcal) &#124; 2011 Case Definition |format= |work= |accessdate=}}</ref>.
 
==== Case Classification ====
* Probable: A case which meets the laboratory criteria and in which four of the five clinical criteria described above are present
 
* Confirmed: A case which meets the laboratory criteria and in which all five of the clinical criteria described above are present, including desquamation, unless the patient dies before desquamation occurshttps<ref name="urlToxic Shock Syndrome (Other Than Streptococcal) | 2011 Case Definition">{{cite web |url=https://wwwn.cdc.gov/nndss/conditions/toxic-shock-syndrome-other-than-streptococcal/case-definition/2011/ |title=Toxic Shock Syndrome (Other Than Streptococcal) &#124; 2011 Case Definition |format= |work= |accessdate=}}</ref>


== Streptococcal TSS ==
== Streptococcal TSS ==
There is a subtle defference between Streptococcal TSS and other types. Group A Streptococcus(GAS) can be isolated in GAS-related TSS patients.
There is a subtle defference between [[Streptococcus|Streptococcal]] TSS and other types. [[Streptococcus|Group A Streptococcus(GAS]]) can be isolated in GAS-related TSS patients.
* Clinical and biochemical criteria of streptococcal TSS and necrotizing fasciitis<ref name="urlwwwnc.cdc.gov">{{cite web |url=https://wwwnc.cdc.gov/eid/article/1/3/pdfs/95-0301.pdf |title=wwwnc.cdc.gov |format= |work= |accessdate=}}</ref>
* Clinical and biochemical criteria of [[Streptococcus|streptococcal]] TSS and [[necrotizing fasciitis]](NF)<ref name="urlwwwnc.cdc.gov">{{cite web |url=https://wwwnc.cdc.gov/eid/article/1/3/pdfs/95-0301.pdf |title=wwwnc.cdc.gov |format= |work= |accessdate=}}</ref>.
{| class="wikitable"
{| class="wikitable"
!Disease presentation
!Disease presentation
Line 48: Line 41:
|-
|-
! rowspan="2" |Streptococal TSS
! rowspan="2" |Streptococal TSS
|A. Isolation of group A Streptococcus
|A. Isolation of group A [[Streptococcus]]
|1. From a sterile site  
|1. From a [[sterile]] site  


2. From a nonsterile body site
2. From a nonsterile body site
Line 57: Line 50:
|B. Clinical signs of severity
|B. Clinical signs of severity
|
|
* Hypotension
* [[Hypotension]]
* Clinical and laboratory abnormalities (requires two or more of the following):  
* Clinical and laboratory abnormalities (requires two or more of the following):  


** Renal impairment
** [[Renal Failure]]
** Coagulopathy
** [[Coagulopathy]]
** Liver abnormalitie
** [[Hepatic failure]]
** Acute respiratory distress syndrome
** [[Acute respiratory distress syndrome]](ARDS)
** Extensive tissue necrosis, i.e., necrotizing fasciitis
** Extensive tissue [[necrosis]], i.e. necrotizing fasciitis
** Erythematous rash
** [[Erythematous]] [[rash]]
|-
|-
! rowspan="2" |Necrotizing fasciitis
! rowspan="2" |Necrotizing fasciitis
|A. Clinical Criteria
|A. Clinical Criteria
|
|
* Necrosis of soft tissues with involvement of the fascia
* [[Necrosis]] of [[Soft tissue|soft tissues]] with involvement of the [[fascia]]


* Serious systemic disease, including one or more of the following: a) Death b) Shock (systolic blood pressure <90 mm of Hg). c) Disseminated intravascular coagulopathy d) Failure of organ systems a. respiratory failure b. liver failure c. renal failure
* Serious systemic disease, including one or more of the following:
** [[Shock]]
** [[Systolic blood pressure]] <90 mm of Hg
** [[Disseminated intravascular coagulopathy]]
** Failure of organ systems
*** [[Respiratory failure]]
*** [[Hepatic failure|Liver failure]]
*** [[Renal failure]]
| rowspan="2" |A+B1
| rowspan="2" |A+B1
| rowspan="2" |A+B2
| rowspan="2" |A+B2
A+B3
A+B3
|-
|-
|B. Isolation of group A Streptococcus
|B. Isolation of group A [[Streptococcus]]
|
|
# Isolation of group A Streptococcus from a normally sterile body site
# Isolation of group A [[Streptococcus]] from a normally [[sterile]] body site
# serologic confirmation of group A streptococcal infection by a 4-fold rise against: a) streptolysin O b) DNase B
# [[Serological testing|Serologic]] confirmation of group A [[Streptococcus|streptococcal]] infection by a 4-fold rise against: a) streptolysin O b) DNase B
# histologic confirmation: Gram-positive cocci in a necrotic soft tissue infection
# [[Histologic]] confirmation: [[Gram-positive cocci]] in a [[Necrotic tissue|necrotic soft tissue infection]]
|}
|}


Revision as of 16:22, 11 May 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]

Overview

The diagnostic criteria varies depend on the organism responsible for the Toxic Shock Syndrome (TSS), but mainly the diagnosis of TSS is based on the clinical presentation.

Diagnostic Criteria

Toxic Shock Syndrome (Other Than Streptococcal) (TSS)

Clinical Criteria

The diagnosis of Staphylococcal toxic shock syndrome (TSS) is based upon clinical presentation as no confirmatory diagnostic criteria is developed yet. A criteria list have been established by United States Centers for Disease Control and Prevention (CDC) for epidemiologic studies on Staphylococcal TSS, mean that a patient can not be excluded from disease based on the absence of one of these criterias when it come to diagnosis terms. This criteria list means that a confirmed case is someone who has fever >38.9°C, hypotension, diffuse erythroderma, desquamation (unless the patient dies before desquamation can occur), and involvement of at least three organ systems. If a patient misses one of these criterias, the case may be considered as a probable/susceptible case.[1]

An illness with the following clinical manifestations:

Laboratory Criteria for Diagnosis

Negative results on the following tests, if obtained:

Streptococcal TSS

There is a subtle defference between Streptococcal TSS and other types. Group A Streptococcus(GAS) can be isolated in GAS-related TSS patients.

Disease presentation criteria Definite case Suspected case
Streptococal TSS A. Isolation of group A Streptococcus 1. From a sterile site

2. From a nonsterile body site

A1+B A2+B
B. Clinical signs of severity
  • Hypotension
  • Clinical and laboratory abnormalities (requires two or more of the following):
Necrotizing fasciitis A. Clinical Criteria A+B1 A+B2

A+B3

B. Isolation of group A Streptococcus
  1. Isolation of group A Streptococcus from a normally sterile body site
  2. Serologic confirmation of group A streptococcal infection by a 4-fold rise against: a) streptolysin O b) DNase B
  3. Histologic confirmation: Gram-positive cocci in a necrotic soft tissue infection

References

  1. ↑ Tofte RW, Williams DN (1981). "Toxic shock syndrome. Evidence of a broad clinical spectrum". JAMA. 246 (19): 2163–7. PMID 7289007.
  2. ↑ cite journal |vauthors= |title=Repeat injuries in an inner city population--Philadelphia, 1987-1988 |journal=MMWR Morb. Mortal. Wkly. Rep. |volume=39 |issue=1 |pages=1–3 |year=1990 |pmid=2294395 |doi= |url=}}
  3. ↑ "Case definitions for infectious conditions under public health surveillance. Centers for Disease Control and Prevention". MMWR Recomm Rep. 46 (RR-10): 1–55. 1997. PMID 9148133.
  4. ↑ "Toxic Shock Syndrome (Other Than Streptococcal) | 2011 Case Definition".
  5. ↑ "wwwnc.cdc.gov" (PDF).


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