Stomach cancer causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]

Overview

Causes of stomach cancer depends on type of cancer. Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria. Diffuse gastric carcinomas do not have a precancerous lesion. Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.

Stomach cancer causes

  • Causes of stomach cancer depends on type of cancer:

Adenocarcinoma

Diffuse gastric carcinoma

  • Diffuse gastric carcinomas do not have a precancerous lesion.

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