Stomach cancer causes: Difference between revisions
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== Stomach cancer causes == | == Stomach cancer causes == | ||
* Causes of stomach cancer depends on type of cancer | * Causes of stomach cancer depends on type of cancer: | ||
==== Adenocarcinoma ==== | |||
* Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria. | * Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria. | ||
* ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and intestinal [[metaplasia]]. | * ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and intestinal [[metaplasia]]. | ||
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* Almost 50% of gastric cancers have alterations in genes ''[[TP53 (gene)|TP53]],'' ''[[TP73L|TP73]]'', ''[[APC]]'', TFF, ''[[DCC1|DCC]]'', LOH, and ''[[FHIT]].'' | * Almost 50% of gastric cancers have alterations in genes ''[[TP53 (gene)|TP53]],'' ''[[TP73L|TP73]]'', ''[[APC]]'', TFF, ''[[DCC1|DCC]]'', LOH, and ''[[FHIT]].'' | ||
* Inactivation of [[P53 (protein)|p53]] in gastric [[epithelial cells]] reduce their ability to undergo [[apoptosis]]. | * Inactivation of [[P53 (protein)|p53]] in gastric [[epithelial cells]] reduce their ability to undergo [[apoptosis]]. | ||
* | |||
==== Diffuse gastric carcinoma ==== | |||
* Diffuse gastric carcinomas do not have a [[precancerous]] lesion. The [[E-cadherin]] [[gene]] (CDH1) encodes a [[Transmembrane protein|transmembrane cellular adhesion protein]]. | |||
* [[Somatic]] [[mutations]] in the ''[[CDH11|CDH1]]'' gene by hypermethylation, [[mutation]], and [[loss of heterozygosity]] are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. | |||
* Prostate stem cell antigen [[gene]] is also involved in regulating gastric [[Epithelium|epithelial cell]] proliferation. | |||
* Its [[Cytoplasm|cytoplasmic]] tail interacts with [[Catenin|catenins]] making the adhesion. | |||
==References== | ==References== | ||
Revision as of 16:30, 4 December 2017
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Overview
Stomach cancer causes
- Causes of stomach cancer depends on type of cancer:
Adenocarcinoma
- Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria.
- K-ras mutations oncogenes are found in invasive cancers and intestinal metaplasia.
- Hepatocyte growth factor receptor c-met oncogene is found in intestinal-type gastric cancers.
- Almost 50% of gastric cancers have alterations in genes TP53, TP73, APC, TFF, DCC, LOH, and FHIT.
- Inactivation of p53 in gastric epithelial cells reduce their ability to undergo apoptosis.
Diffuse gastric carcinoma
- Diffuse gastric carcinomas do not have a precancerous lesion. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.
- Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers.
- Prostate stem cell antigen gene is also involved in regulating gastric epithelial cell proliferation.
- Its cytoplasmic tail interacts with catenins making the adhesion.