Spontaneous coronary artery dissection medical therapy: Difference between revisions
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Although there is no evidence for using long term anti platelet therapy in this specific group of patients, it is reasonable to use [[aspirin]] for acute and long term management with considering [[acute coronary syndrome]] as an indication.<ref name="pmid11786451">{{cite journal| author=Antithrombotic Trialists' Collaboration| title=Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. | journal=BMJ | year= 2002 | volume= 324 | issue= 7329 | pages= 71-86 | pmid=11786451 | doi= | pmc=64503 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11786451 }} [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12093204 Review in: ACP J Club. 2002 Jul-Aug;137(1):5] </ref> | Although there is no evidence for using long term anti platelet therapy in this specific group of patients, it is reasonable to use [[aspirin]] for acute and long term management with considering [[acute coronary syndrome]] as an indication.<ref name="pmid11786451">{{cite journal| author=Antithrombotic Trialists' Collaboration| title=Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. | journal=BMJ | year= 2002 | volume= 324 | issue= 7329 | pages= 71-86 | pmid=11786451 | doi= | pmc=64503 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11786451 }} [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12093204 Review in: ACP J Club. 2002 Jul-Aug;137(1):5] </ref> | ||
It remains controversial to use clopidogrel in patients managed with conservative therapy. However, it seems to be beneficial to use [[clopidogrel]] in acute management to avoid a new [[thrombus]] formation in true lumen on the basis of dissected part and to reduce the [[thrombus]] burden in the false lumen. <ref name="pmid12403896">{{cite journal| author=Choi JW, Davidson CJ| title=Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy. | journal=J Invasive Cardiol | year= 2002 | volume= 14 | issue= 11 | pages= 675-8 | pmid=12403896 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12403896 }} </ref> The effects of [[P2Y12]] antagonists ([[ticagrelor]] and [[prasugrel]]) in management of SCAD patients is not clear. In addition, [[glycoprotein IIb/IIIa inhibitors]] | It remains controversial to use clopidogrel in patients managed with conservative therapy. However, it seems to be beneficial to use [[clopidogrel]] in acute management to avoid a new [[thrombus]] formation in true lumen on the basis of dissected part and to reduce the [[thrombus]] burden in the false lumen. <ref name="pmid12403896">{{cite journal| author=Choi JW, Davidson CJ| title=Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy. | journal=J Invasive Cardiol | year= 2002 | volume= 14 | issue= 11 | pages= 675-8 | pmid=12403896 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12403896 }} </ref> The effects of [[P2Y12]] antagonists ([[ticagrelor]] and [[prasugrel]]) in management of SCAD patients is not clear. In addition, [[glycoprotein IIb/IIIa inhibitors]] should be avoided in these patients because of high risk of bleeding and a potential risk of extending the [[dissection]]. <ref name="pmid23498840">{{cite journal| author=Saw J| title=Spontaneous coronary artery dissection. | journal=Can J Cardiol | year= 2013 | volume= 29 | issue= 9 | pages= 1027-33 | pmid=23498840 | doi=10.1016/j.cjca.2012.12.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23498840 }} </ref> | ||
===Anticoagulant and Thrombolytic Therapy=== | ===Anticoagulant and Thrombolytic Therapy=== | ||
Revision as of 18:55, 5 December 2017
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Spontaneous Coronary Artery Dissection Microchapters |
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Differentiating Spontaneous coronary artery dissection from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Type 1 Type 2A Type 2B Type 3 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A. Arzu Kalayci, M.D. [2]
Synonyms and keywords: SCAD
Overview
There are no specific guidelines regarding the optimal management of spontaneous coronary artery dissection. Based on the clinical and angiographic scenario, treatment options include conservative medical regimens similar to that for acute coronary syndrome, percutaneous coronary intervention, and/or coronary artery bypass surgery.
Medical Therapy
There are no specific guidelines regarding the optimal management of spontaneous coronary artery dissection. Based on the clinical and angiographic scenario, treatment options include conservative medical regimens similar to that for acute coronary syndrome, percutaneous coronary intervention, and/or coronary artery bypass surgery. In the majority of cases, SCAD may be managed successfully with medical treatment alone in the absence of ongoing myocardial ischemia or hemodynamic instability.[1][2] Initial conservative management typically includes antithrombotic therapy with heparin, aspirin, clopidogrel and glycoprotein IIb/IIIa inhibitors, and antiischemic therapy with beta blockers and nitrates. However, the use of antithrombotic therapy may increase the risk of bleeding in the false lumen causing an expansion of the intramural hematoma, resulting in a decreased flow through the true lumen.[3] Fibrinolytics should be avoided. Calcium channel blockers may offer relief in coronary artery spasm.
Beta Blockers
There is a general agreement that beta blockers take the most important place in the medical management of SCAD patients. These agents may improve the outcomes of SCAD patients with reducing vascular wall shear stress likewise in patients with aortic dissection. [4] Furthermore, beta blockers should be used in these group of patients in order to reduce complications of myocardial infarction. [5] [6]
Antiplatelet Therapy
Although there is no evidence for using long term anti platelet therapy in this specific group of patients, it is reasonable to use aspirin for acute and long term management with considering acute coronary syndrome as an indication.[7] It remains controversial to use clopidogrel in patients managed with conservative therapy. However, it seems to be beneficial to use clopidogrel in acute management to avoid a new thrombus formation in true lumen on the basis of dissected part and to reduce the thrombus burden in the false lumen. [8] The effects of P2Y12 antagonists (ticagrelor and prasugrel) in management of SCAD patients is not clear. In addition, glycoprotein IIb/IIIa inhibitors should be avoided in these patients because of high risk of bleeding and a potential risk of extending the dissection. [9]
Anticoagulant and Thrombolytic Therapy
References
- ↑ Saw J, Aymong E, Sedlak T, Buller CE, Starovoytov A, Ricci D; et al. (2014). "Spontaneous coronary artery dissection: association with predisposing arteriopathies and precipitating stressors and cardiovascular outcomes". Circ Cardiovasc Interv. 7 (5): 645–55. doi:10.1161/CIRCINTERVENTIONS.114.001760. PMID 25294399.
- ↑ Tweet MS, Hayes SN, Pitta SR, Simari RD, Lerman A, Lennon RJ; et al. (2012). "Clinical features, management, and prognosis of spontaneous coronary artery dissection". Circulation. 126 (5): 579–88. doi:10.1161/CIRCULATIONAHA.112.105718. PMID 22800851.
- ↑ Vrints, CJ. (2010). "Spontaneous coronary artery dissection". Heart. 96 (10): 801–8. doi:10.1136/hrt.2008.162073. PMID 20448134.
- ↑ Nienaber CA, Powell JT (2012). "Management of acute aortic syndromes". Eur Heart J. 33 (1): 26–35b. doi:10.1093/eurheartj/ehr186. PMID 21810861.
- ↑ Mehta LS, Beckie TM, DeVon HA, Grines CL, Krumholz HM, Johnson MN; et al. (2016). "Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association". Circulation. 133 (9): 916–47. doi:10.1161/CIR.0000000000000351. PMID 26811316.
- ↑ Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR; et al. (2014). "2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". Circulation. 130 (25): 2354–94. doi:10.1161/CIR.0000000000000133. PMID 25249586.
- ↑ Antithrombotic Trialists' Collaboration (2002). "Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients". BMJ. 324 (7329): 71–86. PMC 64503. PMID 11786451. Review in: ACP J Club. 2002 Jul-Aug;137(1):5
- ↑ Choi JW, Davidson CJ (2002). "Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy". J Invasive Cardiol. 14 (11): 675–8. PMID 12403896.
- ↑ Saw J (2013). "Spontaneous coronary artery dissection". Can J Cardiol. 29 (9): 1027–33. doi:10.1016/j.cjca.2012.12.018. PMID 23498840.