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{{Infobox_gene}}
{{PBB_Controls
'''Syntaxin-8''' is a [[protein]] that in humans is encoded by the ''STX8'' [[gene]].<ref name="pmid9852078">{{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34171–9 | date = Dec 1998 | pmid = 9852078 | pmc =  | doi = 10.1074/jbc.273.51.34171 }}</ref><ref name="pmid10198254">{{cite journal | vauthors = Thoreau V, Bergès T, Callebaut I, Guillier-Gencik Z, Gressin L, Bernheim A, Karst F, Mornon JP, Kitzis A, Chomel JC | title = Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8) | journal = Biochemical and Biophysical Research Communications | volume = 257 | issue = 2 | pages = 577–83 | date = Apr 1999 | pmid = 10198254 | pmc =  | doi = 10.1006/bbrc.1999.0503 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STX8 syntaxin 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9482| accessdate = }}</ref>
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Syntaxin 8 directly interacts with [[HECTd3]] and has similar subcellular localization.<ref name="pmid18821010">{{cite journal | vauthors = Zhang L, Kang L, Bond W, Zhang N | title = Interaction between syntaxin 8 and HECTd3, a HECT domain ligase | journal = Cellular and Molecular Neurobiology | volume = 29 | issue = 1 | pages = 115–21 | date = Feb 2009 | pmid = 18821010 | pmc =  | doi = 10.1007/s10571-008-9303-0 }}</ref> The [[protein]] has been shown to form the [[SNARE]] complex with [[syntaxin 7]], [[vti1b]] and [[endobrevin]]. These function as the machinery for the [[homotypic]] fusion of late [[endosomes]].<ref name="pmid17965969">{{cite journal | vauthors = Kasai K, Suga K, Izumi T, Akagawa K | title = Syntaxin 8 has two functionally distinct di-leucine-based motifs | journal = Cellular & Molecular Biology Letters | volume = 13 | issue = 1 | pages = 144–54 | date = October 2008 | pmid = 17965969 | pmc = | doi = 10.2478/s11658-007-0043-9 }}</ref>
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==Model organisms==
{{GNF_Protein_box
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
| image = PBB_Protein_STX8_image.jpg
|+ ''Stx8'' knockout mouse phenotype
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gl2.
|-
| PDB = {{PDB2|1gl2}}
! Characteristic!! Phenotype
| Name = Syntaxin 8
|-
| HGNCid = 11443
| [[Homozygote]] viability || bgcolor="#488ED3"|Normal
| Symbol = STX8
|-
| AltSymbols =; CARB
| Body weight || bgcolor="#488ED3"|Normal
| OMIM = 604203
|-
| ECnumber =
| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
| Homologene = 37973
|-
| MGIid = 1890156
| Neurological assessment || bgcolor="#488ED3"|Normal
| GeneAtlas_image1 = PBB_GE_STX8_204690_at_tn.png
|-
| GeneAtlas_image2 = PBB_GE_STX8_gnf1h09415_s_at_tn.png
| Grip strength || bgcolor="#488ED3"|Normal
| GeneAtlas_image3 = PBB_GE_STX8_gnf1h09416_s_at_tn.png
|-
| Function =  
| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}  
|-
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}  
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
| Orthologs = {{GNF_Ortholog_box
|-
    | Hs_EntrezGene = 9482
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
    | Hs_Ensembl = ENSG00000170310
|-
    | Hs_RefseqProtein = NP_004844
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
    | Hs_RefseqmRNA = NM_004853
|-
    | Hs_GenLoc_db =
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
    | Hs_GenLoc_chr = 17
|-
    | Hs_GenLoc_start = 9094514
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
    | Hs_GenLoc_end = 9420000
|-
    | Hs_Uniprot = Q9UNK0
| [[Radiography]] || bgcolor="#488ED3"|Normal
    | Mm_EntrezGene = 55943
|-
    | Mm_Ensembl = ENSMUSG00000020903
| Body temperature || bgcolor="#488ED3"|Normal
    | Mm_RefseqmRNA = XM_001002438
|-
    | Mm_RefseqProtein = XP_001002438
| Eye morphology || bgcolor="#488ED3"|Normal
    | Mm_GenLoc_db =
|-
    | Mm_GenLoc_chr = 11
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
    | Mm_GenLoc_start = 67782653
|-
    | Mm_GenLoc_end = 68023348
| [[Haematology]] || bgcolor="#488ED3"|Normal
    | Mm_Uniprot = Q5F234
|-
  }}
| [[Peripheral blood lymphocyte]]s || bgcolor="#488ED3"|Normal
}}
|-
'''Syntaxin 8''', also known as '''STX8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STX8 syntaxin 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9482| accessdate = }}</ref>
| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| Skin Histopathology || bgcolor="#488ED3"|Normal
|-
| Brain histopathology || bgcolor="#488ED3"|Normal
|-
| Eye Histopathology || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAKV/salmonella-challenge/ |title=''Salmonella'' infection data for Stx8 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAKV/citrobacter-challenge/ |title=''Citrobacter'' infection data for Stx8 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of STX8 function. A conditional [[knockout mouse]] line, called ''Stx8<sup>tm2a(EUCOMM)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Stx8 |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432376 |title=Mouse Genome Informatics}}</ref> was generated as part of the [[International Knockout Mouse Consortium]] program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists—at the [[Wellcome Trust Sanger Institute]].<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref> Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}</ref> Twenty four tests were carried out on [[homozygous]] [[mutant]] adult mice, however no significant abnormalities were observed.<ref name="mgp_reference" />


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== Interactions ==
{{PBB_Summary
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| summary_text =  
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==References==
STX8 has been shown to [[Protein-protein interaction|interact]] with [[Vesicle-associated membrane protein 8]],<ref name=pmid11101518>{{cite journal | vauthors = Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R | title = A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6453–64 | date = Dec 2000 | pmid = 11101518 | pmc = 305878 | doi = 10.1093/emboj/19.23.6453 }}</ref> [[VTI1B]]<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid10683148>{{cite journal | vauthors = Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W | title = Preferential association of syntaxin 8 with the early endosome | journal = Journal of Cell Science | volume = 113 ( Pt 6) | issue = 6 | pages = 997–1008 | date = Mar 2000 | pmid = 10683148 }}</ref> and [[STX7]].<ref name=pmid11101518/>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH | title = Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking | journal = Molecular Biology of the Cell | volume = 10 | issue = 11 | pages = 3891–908 | date = Nov 1999 | pmid = 10564279 | pmc = 25687 | doi = 10.1091/mbc.10.11.3891 }}
| citations =
* {{cite journal | vauthors = Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W | title = Preferential association of syntaxin 8 with the early endosome | journal = Journal of Cell Science | volume = 113 ( Pt 6) | issue = 6 | pages = 997–1008 | date = Mar 2000 | pmid = 10683148 | doi =  }}
*{{cite journal  | author=Steegmaier M, Yang B, Yoo JS, ''et al.'' |title=Three novel proteins of the syntaxin/SNAP-25 family. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34171-9 |year= 1999 |pmid= 9852078 |doi=  }}
* {{cite journal | vauthors = McShea A, Samuel T, Eppel JT, Galloway DA, Funk JO | title = Identification of CIP-1-associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle | journal = The Journal of Biological Chemistry | volume = 275 | issue = 30 | pages = 23181–6 | date = Jul 2000 | pmid = 10781590 | doi = 10.1074/jbc.M001772200 }}
*{{cite journal  | author=Thoreau V, Bergès T, Callebaut I, ''et al.'' |title=Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 2 |pages= 577-83 |year= 1999 |pmid= 10198254 |doi= 10.1006/bbrc.1999.0503 }}
* {{cite journal | vauthors = Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH | title = SNAREs contribute to the specificity of membrane fusion | journal = Neuron | volume = 26 | issue = 2 | pages = 457–64 | date = May 2000 | pmid = 10839363 | doi = 10.1016/S0896-6273(00)81177-0 }}
*{{cite journal | author=Prekeris R, Yang B, Oorschot V, ''et al.'' |title=Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3891-908 |year= 1999 |pmid= 10564279 |doi= }}
* {{cite journal | vauthors = Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R | title = A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6453–64 | date = Dec 2000 | pmid = 11101518 | pmc = 305878 | doi = 10.1093/emboj/19.23.6453 }}
*{{cite journal | author=Subramaniam VN, Loh E, Horstmann H, ''et al.'' |title=Preferential association of syntaxin 8 with the early endosome. |journal=J. Cell. Sci. |volume=113 ( Pt 6) |issue= |pages= 997-1008 |year= 2000 |pmid= 10683148 |doi=  }}
* {{cite journal | vauthors = Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE | title = Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 19820–7 | date = Jun 2001 | pmid = 11278762 | doi = 10.1074/jbc.M010838200 }}
*{{cite journal | author=McShea A, Samuel T, Eppel JT, ''et al.'' |title=Identification of CIP-1-associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23181-6 |year= 2000 |pmid= 10781590 |doi= 10.1074/jbc.M001772200 }}
* {{cite journal | vauthors = Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR | title = Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs | journal = Nature Structural Biology | volume = 9 | issue = 2 | pages = 107–11 | date = Feb 2002 | pmid = 11786915 | doi = 10.1038/nsb746 }}
*{{cite journal | author=Scales SJ, Chen YA, Yoo BY, ''et al.'' |title=SNAREs contribute to the specificity of membrane fusion. |journal=Neuron |volume=26 |issue= 2 |pages= 457-64 |year= 2000 |pmid= 10839363 |doi= }}
* {{cite journal | vauthors = Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F | title = Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum | journal = The Biochemical Journal | volume = 368 | issue = Pt 1 | pages = 29–39 | date = Nov 2002 | pmid = 12175335 | pmc = 1222979 | doi = 10.1042/BJ20020845 }}
*{{cite journal | author=Antonin W, Holroyd C, Fasshauer D, ''et al.'' |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6453-64 |year= 2001 |pmid= 11101518 |doi= 10.1093/emboj/19.23.6453 }}
* {{cite journal | vauthors = Xu Y, Martin S, James DE, Hong W | title = GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus | journal = Molecular Biology of the Cell | volume = 13 | issue = 10 | pages = 3493–507 | date = Oct 2002 | pmid = 12388752 | pmc = 129961 | doi = 10.1091/mbc.E02-01-0004 }}
*{{cite journal | author=Wade N, Bryant NJ, Connolly LM, ''et al.'' |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820-7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 }}
* {{cite journal | vauthors = Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C | title = Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 3 | pages = 577–82 | date = Nov 2003 | pmid = 14623309 | doi = 10.1016/j.bbrc.2003.10.030 }}
*{{cite journal | author=Antonin W, Fasshauer D, Becker S, ''et al.'' |title=Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. |journal=Nat. Struct. Biol. |volume=9 |issue= 2 |pages= 107-11 |year= 2002 |pmid= 11786915 |doi= 10.1038/nsb746 }}
* {{cite journal | vauthors = Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA | title = Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease | journal = Journal of Neuroscience Research | volume = 75 | issue = 5 | pages = 698–703 | date = Mar 2004 | pmid = 14991845 | doi = 10.1002/jnr.20028 }}
*{{cite journal | author=Bogdanovic A, Bennett N, Kieffer S, ''et al.'' |title=Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum. |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 29-39 |year= 2002 |pmid= 12175335 |doi= 10.1042/BJ20020845 }}
* {{cite journal | vauthors = Bilan F, Thoreau V, Nacfer M, Dérand R, Norez C, Cantereau A, Garcia M, Becq F, Kitzis A | title = Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity | journal = Journal of Cell Science | volume = 117 | issue = Pt 10 | pages = 1923–35 | date = Apr 2004 | pmid = 15039462 | doi = 10.1242/jcs.01070 }}
*{{cite journal | author=Xu Y, Martin S, James DE, Hong W |title=GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3493-507 |year= 2003 |pmid= 12388752 |doi= 10.1091/mbc.E02-01-0004 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = Mar 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Kim BY, Ueda M, Kominami E, ''et al.'' |title=Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 577-82 |year= 2004 |pmid= 14623309 |doi= }}
*{{cite journal | author=Zhu X, McShea A, Harris PL, ''et al.'' |title=Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. |journal=J. Neurosci. Res. |volume=75 |issue= 5 |pages= 698-703 |year= 2004 |pmid= 14991845 |doi= 10.1002/jnr.20028 }}
*{{cite journal | author=Bilan F, Thoreau V, Nacfer M, ''et al.'' |title=Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity. |journal=J. Cell. Sci. |volume=117 |issue= Pt 10 |pages= 1923-35 |year= 2005 |pmid= 15039462 |doi= 10.1242/jcs.01070 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9482}}
{{WikiDoc Sources}}
{{Vesicular transport proteins}}
 
[[Category:Genes mutated in mice]]

Latest revision as of 16:21, 8 October 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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UniProt

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Wikidata
View/Edit Human

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene.[1][2][3] Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization.[4] The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.[5]

Model organisms

Model organisms have been used in the study of STX8 function. A conditional knockout mouse line, called Stx8tm2a(EUCOMM)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists—at the Wellcome Trust Sanger Institute.[12][13][14] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty four tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.[8]

Interactions

STX8 has been shown to interact with Vesicle-associated membrane protein 8,[16] VTI1B[17][18] and STX7.[16]

References

  1. ↑ Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  2. ↑ Thoreau V, Bergès T, Callebaut I, Guillier-Gencik Z, Gressin L, Bernheim A, Karst F, Mornon JP, Kitzis A, Chomel JC (Apr 1999). "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)". Biochemical and Biophysical Research Communications. 257 (2): 577–83. doi:10.1006/bbrc.1999.0503. PMID 10198254.
  3. ↑ "Entrez Gene: STX8 syntaxin 8".
  4. ↑ Zhang L, Kang L, Bond W, Zhang N (Feb 2009). "Interaction between syntaxin 8 and HECTd3, a HECT domain ligase". Cellular and Molecular Neurobiology. 29 (1): 115–21. doi:10.1007/s10571-008-9303-0. PMID 18821010.
  5. ↑ Kasai K, Suga K, Izumi T, Akagawa K (October 2008). "Syntaxin 8 has two functionally distinct di-leucine-based motifs". Cellular & Molecular Biology Letters. 13 (1): 144–54. doi:10.2478/s11658-007-0043-9. PMID 17965969.
  6. ↑ "Salmonella infection data for Stx8". Wellcome Trust Sanger Institute.
  7. ↑ "Citrobacter infection data for Stx8". Wellcome Trust Sanger Institute.
  8. ↑ 8.0 8.1 8.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ↑ "International Knockout Mouse Consortium".
  11. ↑ "Mouse Genome Informatics".
  12. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  15. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  16. ↑ 16.0 16.1 Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
  17. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  18. ↑ Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W (Mar 2000). "Preferential association of syntaxin 8 with the early endosome". Journal of Cell Science. 113 ( Pt 6) (6): 997–1008. PMID 10683148.

Further reading

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