Protein energy malnutrition pathophysiology: Difference between revisions

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{{Protein energy malnutrition}}
{{Protein energy malnutrition}}


{{CMG}}; {{AE}} {{DAMI}}
{{CMG}}; {{AE}} {{DAMI}}, {{HK}}


==Overview==
==Overview==
It is thought that [[kwashiorkor]] is produced by a deficiency in the adequate consumption of protein rich foods during the [[weaning]] process. However, the associated [[edema]] is not fully understand. Several [[Theory|theories]] have been put forward to explain this finding.
Protein-energy malnutrition represents a shift of the body from fed to fasting/starvation state. Starvation leads to a decreased basal [[Blood plasma|plasma]] [[insulin]] concentration and in decrease of [[glucose]]-stimulated [[insulin]] secretion. Prolonged fasting results in a deficiency in [[Amino acid|amino acids]] used for [[gluconeogenesis]]. It is thought that [[kwashiorkor]] is produced by a deficiency in the adequate consumption of [[Protein|protein-]]<nowiki/>rich foods during the [[weaning]] process. However, the associated [[edema]] is not fully understood. Several [[Theory|theories]] have been put forward to explain this finding. [[Marasmus]] on the other hand is thought to be due to the total [[Calorie|caloric]] deficiency leading to [[wasting]]<nowiki/>in a child. [[Marasmus]] always results from a negative energy balance.
 
[[Marasmus]] on the other hand is thought to be due to the total caloric deficiency leading to [[wasting]] in a child. [[Marasmus]] always results from a negative energy balance.


==Pathophysiology==
==Pathophysiology==
Several studies have shown that a deficiency in the consumption of [[protein]], [[carbohydrates]] and [[fat]] is responsible for the development of protein energy malnutrition. However, other studies propose that [[Chronic|chronic infections]] such as [[Helminthic therapy|helminthic]] [[infections]] are mainly responsible for the development of protein energy malnutrition.<ref name="pmid7825621">{{cite journal| author=Cederholm T, Jägrén C, Hellström K| title=Outcome of protein-energy malnutrition in elderly medical patients. | journal=Am J Med | year= 1995 | volume= 98 | issue= 1 | pages= 67-74 | pmid=7825621 | doi=10.1016/S0002-9343(99)80082-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7825621  }} </ref> The underlying mechanisms include the following:
Several studies have shown that a deficiency in the consumption of [[protein]], [[carbohydrates]] and [[fat]] is responsible for the development of protein-energy malnutrition. However, other studies have proposed that [[Chronic|chronic infections]] such as [[Helminthic therapy|helminthic]] [[infections]] are mainly responsible for the development of protein-energy malnutrition.<ref name="pmid7825621">{{cite journal| author=Cederholm T, Jägrén C, Hellström K| title=Outcome of protein-energy malnutrition in elderly medical patients. | journal=Am J Med | year= 1995 | volume= 98 | issue= 1 | pages= 67-74 | pmid=7825621 | doi=10.1016/S0002-9343(99)80082-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7825621  }} </ref> The underlying mechanisms include the following:
*Decreased food intake because of [[anorexia]]  
*Decreased food intake because of [[anorexia]]  
*Decreased [[nutrient]] [[absorption]]
*Decreased [[nutrient]] [[absorption]]
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*Direct [[nutrient]] losses  
*Direct [[nutrient]] losses  


The pathologic changes involved in protein energy malnutrition include:<ref name="pmid5095523">{{cite journal| author=Lerner AB| title=On the etiology of vitiligo and gray hair. | journal=Am J Med | year= 1971 | volume= 51 | issue= 2 | pages= 141-7 | pmid=5095523 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5095523  }} </ref>
The pathologic changes involved in protein-energy malnutrition include:<ref name="pmid5095523">{{cite journal| author=Lerner AB| title=On the etiology of vitiligo and gray hair. | journal=Am J Med | year= 1971 | volume= 51 | issue= 2 | pages= 141-7 | pmid=5095523 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5095523  }} </ref>
*[[Immunology|Immunologic deficiency]] in the [[humoral]] and [[cellular]] subsystem as a result of [[protein]] deficiency.
*[[Immunology|Immunologic deficiency]] in the [[humoral]] and [[cellular]] subsystem as a result of [[protein]] deficiency.
*[[Metabolic disorder|Metabolic disturbances]] cause impaired [[Intercellular communication|intercellular]] [[degradation]] of [[fatty acids]] as a result of [[carbohydrate]] [[deficiency]].
*[[Metabolic disorder|Metabolic disturbances]] cause impaired [[Intercellular communication|intercellular]] [[degradation]] of [[fatty acids]] as a result of [[carbohydrate]] [[deficiency]].
*Poor synthesis of [[pigments]] in the [[hair]] and [[skin]] observed with more [[frequency]] among children with low levels of [[Zinc]].
*Poor synthesis of [[pigments]] in the [[hair]] and [[skin]] is observed, with more [[frequency]] among children with low levels of [[zinc]].
 
== Pathogenesis ==
 
=== Hormonal and molecular mechanisms (fed to starvation state) ===
* Protein-energy malnutrition represents a shift of the body from fed to fasting/starvation state.
* The post-fed state may be considered as a useful reference point, as it denotes the period of [[Metabolism|metabolic]] transition from the fed to the fasted condition.
* [[Physiological|Physiologically]], the decrease in circulating [[insulin]] to postabsorptive levels results in a marked reduction of [[glucose]] uptake by peripheral [[insulin]]-dependent [[tissues]] ([[muscle]] and [[Adipose tissue|adipose tissues]]) and a shift toward utilization of [[fatty acids]] as energy currency.
* [[Glucose]] consumption continues by non-[[insulin]] dependent [[Tissue (biology)|tissues]] ([[brain]], [[renal medulla]], and formed elements of the [[blood]]) and the [[splanchnic]] bed.
* The major site of [[glucose]] utilization is the [[brain]], which depends completely upon a continuous supply of [[glucose]] for [[oxidative metabolism]] during pot-absorptive state.
* Maintenance of [[blood]] [[glucose]] balance is achieved by the [[hepatic]] production of [[glucose]] at rates equal to those of [[Tissue (biology)|tissue]] utilization.
'''Insulin and glucagon in starvation'''
* Starvation leads to a decreased basal [[Blood plasma|plasma]] [[insulin]] concentration and in decrease of [[glucose]]-stimulated [[insulin]] secretion. There is also an increase in counter-regulatory [[hormone]] concentration, for example, [[glucagon]], [[cortisol]] and [[catecholamines]] in order to replete the [[glucose]] levels in the [[blood plasma]].<ref name="pmid4686383">{{cite journal |vauthors=Saudek CD, Boulter PR, Arky RA |title=The natriuretic effect of glucagon and its role in starvation |journal=J. Clin. Endocrinol. Metab. |volume=36 |issue=4 |pages=761–5 |year=1973 |pmid=4686383 |doi=10.1210/jcem-36-4-761 |url=}}</ref><ref name="pmid4155624">{{cite journal |vauthors=Hedeskov CJ, Capito K |title=The effect of starvation on insulin secretion and glucose metabolism in mouse pancreatic islets |journal=Biochem. J. |volume=140 |issue=3 |pages=423–33 |year=1974 |pmid=4155624 |pmc=1168019 |doi= |url=}}</ref>
* In case of starvation, there is regulated and controlled production of [[ketone bodies]] causes a harmless [[physiological]] state known as dietary [[ketosis]]. In [[ketosis]], the [[blood]] [[pH]] remains within normal limits.<ref name="urlWiley: Metabolism at a Glance, 3rd Edition - J. G. Salway3">{{cite web |url=http://www.wiley.com/WileyCDA/WileyTitle/productCd-1118682076.html |title=Wiley: Metabolism at a Glance, 3rd Edition - J. G. Salway |format= |work= |accessdate=}}</ref>
 
* The rate of [[lipolysis]] and [[ketogenesis]] depends upon the action of three [[enzymes]]:<sup>[[Diabetic ketoacidosis pathophysiology#cite note-urlKetone bodies: a review of physiology.2C pathophysiology and application of monitoring to diabetes - Laffel - 1999 - Diabetes.2FMetabolism Research and Reviews - Wiley Online Library-5|[5]]]</sup>
** '''[[Hormone-sensitive lipase]]''' (or triglyceride lipase), which is found in peripheral [[adipocytes]]
** '''Acetyl CoA carboxylase''', which is found in the [[liver]]
** '''Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase''' (mHS), which is also found in the [[liver]]
 
* [[Insulin]] and [[glucagon]] play the key roles in regulating [[lipolysis]] and [[ketogenesis]] by acting in opposition to each other.
* [[Insulin]] inhibits [[ketogenesis]] by causing the [[dephosphorylation]] of [[hormone-sensitive lipase]] ([[Hormone-sensitive lipase|HSL]]) and leads to [[lipogenesis]] by stimulating acetyl CoA carboxylase.<sup>[[Diabetic ketoacidosis pathophysiology#cite note-pmid14641008-6|[6]]]</sup>
* In the [[adipose tissue]], [[dephosphorylation]] of [[hormone-sensitive lipase]] ([[Hormone sensitive lipase|HSL]]) decreases the degradation of [[triglycerides]] into [[fatty acids]] and [[glycerol]], the [[rate-limiting step]] in the release of [[free fatty acids]] from the [[adipocyte]]. This subsequently reduces the amount of [[substrate]] that is available for [[ketogenesis]].<sup>[[Diabetic ketoacidosis pathophysiology#cite note-pmid4146798-7|[7]]]</sup>
* [[Insulin]] also [[Dephosphorylation|dephosphorylates]] the [[inhibitory]] sites on acetyl CoA carboxylase leading to [[enzyme]] activation and increased production of [[Malonyl-CoA|malonyl CoA]]. [[Malonyl-CoA|Malonyl CoA]] [[Inhibitor|inhibits]][[beta oxidation]] of [[fatty acids]] thereby decreasing [[ketogenesis]].<sup>[[Diabetic ketoacidosis pathophysiology#cite note-pmid4146798-7|[7]]]</sup>
* [[Glucagon]] stimulates [[ketogenesis]] by causing the [[phosphorylation]] of both [[hormone-sensitive lipase]] ([[Hormone-sensitive lipase|HSL]]) and acetyl CoA carboxylase via [[cyclic AMP]]-dependent [[protein kinase]]. In the [[adipocytes]], [[phosphorylation]] of [[lipase]] by [[cyclic AMP]]-dependent [[protein kinase]] causes degradation of [[triglycerides]] into [[fatty acids]].<sup>[[Diabetic ketoacidosis pathophysiology#cite note-pmid6122545-8|[8]]][[Diabetic ketoacidosis pathophysiology#cite note-pmid2858203-9|[9]]]</sup>
* In [[Hepatocyte|hepatocytes]], [[phosphorylation]] of [[Acetyl-CoA carboxylase|acetyl CoA carboxylase]] by [[cyclic AMP]]-dependent [[protein kinase]] decreases the production of [[Malonyl-CoA|malonyl CoA]] which subsequently stimulates [[fatty acid]] uptake by the [[mitochondria]] of the [[Cell (biology)|cells]] for [[oxidation]], and thus increases the amount of [[substrate]] available for [[ketogenesis]].
* The activity of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHS) is increased by [[starvation]] and a high-fat [[Diet (nutrition)|diet]], and it is decreased by [[insulin]].<sup>[[Diabetic ketoacidosis pathophysiology#cite note-pmid7902069-10|[10]]]</sup>
'''Eventual decreased gluconeogenesis in protein-energy malnutrition'''
* Prolonged fasting results in a deficiency in [[Amino acid|amino acids]] used for [[gluconeogenesis]].
* [[Glucagon]] concentrations have been found to be lower in children with kwashiorkor compared with marasmus but similar to normal controls.<ref name="urlPediatric Research - Mechanisms Behind Decreased Endogenous Glucose Production in Malnourished Children">{{cite web |url=https://www.nature.com/pr/journal/v68/n5-1/full/pr2010201a.html |title=Pediatric Research - Mechanisms Behind Decreased Endogenous Glucose Production in Malnourished Children |format= |work= |accessdate=}}</ref>
'''Malnutrition, Leptin, and Immunity'''
* [[Leptin]] is a central mediator connecting [[nutrition]] and [[Immunity (medical)|immunity]].<ref name="pmid9250134">{{cite journal |vauthors=Scrimshaw NS, SanGiovanni JP |title=Synergism of nutrition, infection, and immunity: an overview |journal=Am. J. Clin. Nutr. |volume=66 |issue=2 |pages=464S–477S |year=1997 |pmid=9250134 |doi= |url=}}</ref>
* Protein-energy malnutrition reduces [[leptin]] concentrations and increases [[serum]] levels of [[Stress hormone|stress hormones]], i.e., [[glucocorticoids]].<ref name="pmid16514171">{{cite journal |vauthors=Monk JM, Makinen K, Shrum B, Woodward B |title=Blood corticosterone concentration reaches critical illness levels early during acute malnutrition in the weanling mouse |journal=Exp. Biol. Med. (Maywood) |volume=231 |issue=3 |pages=264–8 |year=2006 |pmid=16514171 |doi= |url=}}</ref>
* [[Leptin]] concentrations are related to body adipose tissue and are rapidly reduced by fasting.
* Low [[leptin]] concentrations and [[glucocorticoids]] impair [[macrophage]] functions by decreasing [[NF-kB]] translocation into the [[nucleus]].<ref name="pmid9079197">{{cite journal |vauthors=Auphan N, Didonato JA, Helmberg A, Rosette C, Karin M |title=Immunoregulatory genes and immunosuppression by glucocorticoids |journal=Arch. Toxicol. Suppl. |volume=19 |issue= |pages=87–95 |year=1997 |pmid=9079197 |doi= |url=}}</ref>


=== Pathogenesis of marasmus ===
=== Pathogenesis of marasmus ===
When [[subcutaneous fat]] and [[muscle]] are lost because of [[endogenous]] mobilization of all available [[energy]] and [[nutrients]], [[marasmus]] is diagnosed. The overall [[metabolic]] adaptations that occur during [[marasmus]] are similar to those in [[starvation]]. Initially, [[gluconeogenesis]] aims at maintaining the [[energy]] requirements of the body leading to a perceived increased [[metabolic rate]]. As [[Fasting plasma glucose|fasting]] progresses, [[gluconeogenesis]] is suppressed to minimize [[Muscle atrophy|muscle protein breakdown]], and [[ketones]] derived from [[fat]] become the main [[fuel]] for the [[brain]]. One of the main [[Adaptation|adaptations]] to long-standing [[energy]] [[deficiency]] is a decreased rate of [[Growth|linear growth]], leading to permanent [[Stunted growth|stunting]].
* Marasmus results when [[subcutaneous fat]] and [[muscle]] are lost because of [[endogenous]] mobilization of all available [[energy]] and [[nutrients]].  
* The overall [[metabolic]] adaptations that occur during [[marasmus]] are similar to those in [[starvation]].
* Initially, [[gluconeogenesis]] is triggered and aims at maintaining the [[energy]] requirements of the body leading to a perceived increase in [[metabolic rate]].
* As [[Fasting plasma glucose|fasting]] progresses, [[gluconeogenesis]] is suppressed to minimize [[Muscle atrophy|muscle protein breakdown]], and [[ketones]] derived from [[fat]] become the main [[fuel]] for the [[brain]].
* One of the main [[Adaptation|adaptations]] to long-standing [[energy]] [[deficiency]] is a decreased rate of [[Growth|linear growth]], leading to permanent [[Stunted growth|stunting]].


=== Pathogenesis of edema in kwashiorkor ===
=== Pathogenesis of edema in kwashiorkor ===
Several [[Theory|theories]] have been postulated to explain the mechanism of [[edema]] seen in children with [[kwashiorkor]]. Some of them include:
Several [[Theory|theories]] have been postulated to explain the mechanism of [[edema]] seen in children with [[kwashiorkor]]. Some of them include:


'''1. Protein deficiency/[[hypoalbuminemia]]''' : It was initially believed that a deficiency in the consumption of [[protein]] was responsible for the development of [[kwashiorkor]] in [[children]].  
'''1. Protein deficiency / [[hypoalbuminemia]]'''  
 
It was initially believed that a deficiency in the consumption of [[protein]] was responsible for the development of [[kwashiorkor]] in [[children]].  
*[[Albumin]] [[concentrations]] were also noted to increase steadily within two weeks after [[refeeding]].
*[[Albumin]] [[concentrations]] were also noted to increase steadily within two weeks after [[refeeding]].
*Presence of features similar to [[congenital nephrotic syndrome]], in which the primary [[pathology]] is [[renal]] loss of [[albumin]].<ref name="pmid25223408">{{cite journal| author=Coulthard MG| title=Oedema in kwashiorkor is caused by hypoalbuminaemia. | journal=Paediatr Int Child Health | year= 2015 | volume= 35 | issue= 2 | pages= 83-9 | pmid=25223408 | doi=10.1179/2046905514Y.0000000154 | pmc=4462841 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25223408  }} </ref>
*Presence of features similar to [[congenital nephrotic syndrome]], in which the primary [[pathology]] is [[renal]] loss of [[albumin]].<ref name="pmid25223408">{{cite journal| author=Coulthard MG| title=Oedema in kwashiorkor is caused by hypoalbuminaemia. | journal=Paediatr Int Child Health | year= 2015 | volume= 35 | issue= 2 | pages= 83-9 | pmid=25223408 | doi=10.1179/2046905514Y.0000000154 | pmc=4462841 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25223408  }} </ref>
Multiple [[Evidence|evidences]] have now shown that inadequate intake of [[dietary]] [[protein]] is not the primary trigger for [[edematous malnutrition]].
Multiple [[Evidence|evidences]] have now shown that inadequate intake of [[dietary]] [[protein]] is not the primary trigger for [[edematous malnutrition]].
*Some [[patients]] have [[edematous malnutrition]] without [[hypoalbuminemia]]
*Some [[patients]] have [[edematous malnutrition]] without [[hypoalbuminemia]].
*Others develop [[edematous malnutrition]] ([[kwashiorkor]]) despite adequate proportion of [[protein]] in the diet (eg, in exclusively [[Breastfeeding|breastfed]] [[infants]])
*Others develop [[edematous malnutrition]] ([[kwashiorkor]]) despite adequate proportion of [[protein]] in the diet (e.g, in exclusively [[Breastfeeding|breastfed]] [[infants]]).
*Others recover from [[edematous malnutrition]] with supportive care even without enhancing the [[protein]] content of the [[diet]].<ref name="pmid9830208">{{cite journal| author=Golden MH| title=Oedematous malnutrition. | journal=Br Med Bull | year= 1998 | volume= 54 | issue= 2 | pages= 433-44 | pmid=9830208 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9830208  }} </ref><ref name="pmid20345018">{{cite journal| author=Manary MJ, Heikens GT, Golden M| title=Kwashiorkor: more hypothesis testing is needed to understand the aetiology of oedema. | journal=Malawi Med J | year= 2009 | volume= 21 | issue= 3 | pages= 106-7 | pmid=20345018 | doi= | pmc=3717490 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20345018  }} </ref><ref name="pmid25844980">{{cite journal| author=Golden MH| title=Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium - a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia. | journal=Paediatr Int Child Health | year= 2015 | volume= 35 | issue= 2 | pages= 90-109 | pmid=25844980 | doi=10.1179/2046905515Y.0000000010 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25844980  }} </ref>
*Some recover from [[edematous malnutrition]] with supportive care even without enhancing the [[protein]] content of the [[diet]].<ref name="pmid9830208">{{cite journal| author=Golden MH| title=Oedematous malnutrition. | journal=Br Med Bull | year= 1998 | volume= 54 | issue= 2 | pages= 433-44 | pmid=9830208 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9830208  }} </ref><ref name="pmid20345018">{{cite journal| author=Manary MJ, Heikens GT, Golden M| title=Kwashiorkor: more hypothesis testing is needed to understand the aetiology of oedema. | journal=Malawi Med J | year= 2009 | volume= 21 | issue= 3 | pages= 106-7 | pmid=20345018 | doi= | pmc=3717490 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20345018  }} </ref><ref name="pmid25844980">{{cite journal| author=Golden MH| title=Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium - a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia. | journal=Paediatr Int Child Health | year= 2015 | volume= 35 | issue= 2 | pages= 90-109 | pmid=25844980 | doi=10.1179/2046905515Y.0000000010 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25844980 }} </ref>
 
'''2. [[Oxidant|Oxidant stress]]'''
* Excessive [[Oxidant|oxidant stress]] was also proposed as a mechanism of development of [[kwashiorkor]], however, it was discovered that that the administration of [[antioxidant]] was not successful in the [[Prevention (medical)|prevention]] of the development of this [[malnutrition]] in a series of trials.
* [[Antioxidant]] depletion is a consequence rather than cause of [[kwashiorkor]].<ref name="pmid15851401">{{cite journal| author=Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M| title=Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. | journal=BMJ | year= 2005 | volume= 330 | issue= 7500 | pages= 1109 | pmid=15851401 | doi=10.1136/bmj.38427.404259.8F | pmc=557886 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15851401  }} </ref>
'''3. [[Microbiome]]'''
* Changes in [[intestinal]] [[microbiome]] have also been suggested as a cause of the development of [[kwashiorkor]].
* This has not been fully supported because evidence shows that neither the [[Microbiota|fecal microbiota]] transfer nor the local [[Diet (nutrition)|diet]] alone was sufficient to cause the [[malnutrition]] leading to the conclusion that changes in [[Microbiota|fecal microbiota]] are only effects rather than causes of [[kwashiorkor]].<ref name="pmid23363771">{{cite journal| author=Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J et al.| title=Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. | journal=Science | year= 2013 | volume= 339 | issue= 6119 | pages= 548-54 | pmid=23363771 | doi=10.1126/science.1229000 | pmc=3667500 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23363771  }} </ref><ref name="pmid23576812">{{cite journal| author=Prentice AM, Nabwera H, Kwambana B, Antonio M, Moore SE| title=Microbes and the malnourished child. | journal=Sci Transl Med | year= 2013 | volume= 5 | issue= 180 | pages= 180fs11 | pmid=23576812 | doi=10.1126/scitranslmed.3006212 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23576812  }} </ref><ref name="pmid25717097">{{cite journal| author=Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I et al.| title=Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. | journal=Sci Transl Med | year= 2015 | volume= 7 | issue= 276 | pages= 276ra24 | pmid=25717097 | doi=10.1126/scitranslmed.aaa4877 | pmc=4423598 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25717097 }} </ref>


'''2. [[Oxidant]] stress''' : Excessive [[Oxidant|oxidant stress]] was also proposed as a mechanism of development of [[kwashiorkor]], however, it was discovered that that the administration of [[antioxidant]] was not successful in prevention of the development of this [[malnutrition]] in a series of trials. Hence the conclusion that [[antioxidant]] depletion is a consequence rather than cause of [[kwashiorkor]].<ref name="pmid15851401">{{cite journal| author=Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M| title=Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. | journal=BMJ | year= 2005 | volume= 330 | issue= 7500 | pages= 1109 | pmid=15851401 | doi=10.1136/bmj.38427.404259.8F | pmc=557886 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15851401  }} </ref>
==Genetics==
Protein-energy malnutrition is frequently reported in [[Cri du chat syndrome]](CDS), a [[genetic disease]] that causes [[developmental delay]] and global [[growth retardation]].


'''3. Microbiome''' : Changes in intestinal  microbiome has also been suggested as a cause of the development of kwashiorkor. However, these has not been fully supported because evidences show that neither the fecal microbiota transfer nor the local diet alone was sufficient to cause the malnutrition leading to the conclusion that changes in fecal microbiota are only effects rather than causes of kwashiorkor.<ref name="pmid23363771">{{cite journal| author=Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J et al.| title=Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. | journal=Science | year= 2013 | volume= 339 | issue= 6119 | pages= 548-54 | pmid=23363771 | doi=10.1126/science.1229000 | pmc=3667500 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23363771  }} </ref><ref name="pmid23576812">{{cite journal| author=Prentice AM, Nabwera H, Kwambana B, Antonio M, Moore SE| title=Microbes and the malnourished child. | journal=Sci Transl Med | year= 2013 | volume= 5 | issue= 180 | pages= 180fs11 | pmid=23576812 | doi=10.1126/scitranslmed.3006212 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23576812  }} </ref><ref name="pmid25717097">{{cite journal| author=Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I et al.| title=Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. | journal=Sci Transl Med | year= 2015 | volume= 7 | issue= 276 | pages= 276ra24 | pmid=25717097 | doi=10.1126/scitranslmed.aaa4877 | pmc=4423598 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25717097  }} </ref>
==Associated conditions==
Some of the conditions that are associated with [[kwashiorkor]] include:
*[[Vitamin A deficiency]]
*[[Vitamin D deficiency]]
*[[Thiamine deficiency]]
*[[Zinc deficiency]]
*[[Iodine deficiency]]
*[[Iron deficiency]]
*[[Dehydration]]
*[[Sepsis]]
*''[[Shigella]]'' and ''[[Campylobacter]]'' infections


===Genetics===
==Gross pathology==
Protein energy malnutrition is frequently reported in Cri du chat syndrome(CDS), a genetic disease that causes developmental delay and global growth retardation.
[[Autopsy|Post mortem examination]] of the [[liver]] shows the presence of [[Fatty liver|fatty infiltration]] and [[necrosis]] which disappears with adequate treatment.<ref name="Lefrancde Luca2016">{{cite journal|last1=Lefranc|first1=Violaine|last2=de Luca|first2=Arnaud|last3=Hankard|first3=Régis|title=Protein-energy malnutrition is frequent and precocious in children with cri du chat syndrome|journal=American Journal of Medical Genetics Part A|volume=170|issue=5|year=2016|pages=1358–1362|issn=15524825|doi=10.1002/ajmg.a.37597}}</ref>


===Associated conditions===
==Microscopic pathology==
Some of the conditions that are associated with kwashiokor include;
Both in kwashiorkor and marasmus [[hair analysis]] is therefore advocated as a useful diagnostic procedure for both conditions. In both cases, there is a decrease in the amount of [[melanin]] present in the [[Scalp|scalp hair.]]
*Vitamin A deficiency
*Vitamin D deficiency
*Thiamine deficiency
*Zinc deficiency
*Iodine deficiency
*Iron deficiency
*Dehydration
*Sepsis
*Shigella and Campylobacter infections.


===Gross pathology===
=== Kwashiorkor ===
Post mortem examination of the liver shows the presence of fatty infiltration and necrosis which disappears with adequate treatment.<ref name="Lefrancde Luca2016">{{cite journal|last1=Lefranc|first1=Violaine|last2=de Luca|first2=Arnaud|last3=Hankard|first3=Régis|title=Protein-energy malnutrition is frequent and precocious in children with cri du chat syndrome|journal=American Journal of Medical Genetics Part A|volume=170|issue=5|year=2016|pages=1358–1362|issn=15524825|doi=10.1002/ajmg.a.37597}}</ref>
* In [[kwashiorkor]], [[Microscopy|microscopic studies]] reveal a decreased proportion of [[hairs]] in [[Anagen hair|anagen follicles]]


===Microscopic pathology===
=== Marasmus ===
In kwashiorkor, microscopic studies reveal a decreased proportion of hairs in anagen follicles.
* In [[marasmic]] patients, no [[hairs]] were in the [[Anagen hair|anagen phase,]] with a shift to the [[Telogen Effluvium|telogen phase]]
In marasmic patients, no hairs were in the anagen phase, with a shift to the telogen phase. Marasmic patients have many more broken hairs when compared with patients with kwashiorkor. Hair analysis is therefore advocated as a useful diagnostic procedure for both conditions.
* [[Marasmic]] patients have many more broken hairs when compared with patients with [[kwashiorkor]]
In both cases, there is a decrease in the amount of melanin present in the scalp hair.


==References==
==References==

Latest revision as of 19:49, 20 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2], Syed Hassan A. Kazmi BSc, MD [3]

Overview

Protein-energy malnutrition represents a shift of the body from fed to fasting/starvation state. Starvation leads to a decreased basal plasma insulin concentration and in decrease of glucose-stimulated insulin secretion. Prolonged fasting results in a deficiency in amino acids used for gluconeogenesis. It is thought that kwashiorkor is produced by a deficiency in the adequate consumption of protein-rich foods during the weaning process. However, the associated edema is not fully understood. Several theories have been put forward to explain this finding. Marasmus on the other hand is thought to be due to the total caloric deficiency leading to wastingin a child. Marasmus always results from a negative energy balance.

Pathophysiology

Several studies have shown that a deficiency in the consumption of protein, carbohydrates and fat is responsible for the development of protein-energy malnutrition. However, other studies have proposed that chronic infections such as helminthic infections are mainly responsible for the development of protein-energy malnutrition.[1] The underlying mechanisms include the following:

The pathologic changes involved in protein-energy malnutrition include:[2]

Pathogenesis

Hormonal and molecular mechanisms (fed to starvation state)

Insulin and glucagon in starvation

Eventual decreased gluconeogenesis in protein-energy malnutrition

  • Prolonged fasting results in a deficiency in amino acids used for gluconeogenesis.
  • Glucagon concentrations have been found to be lower in children with kwashiorkor compared with marasmus but similar to normal controls.[6]

Malnutrition, Leptin, and Immunity

Pathogenesis of marasmus

Pathogenesis of edema in kwashiorkor

Several theories have been postulated to explain the mechanism of edema seen in children with kwashiorkor. Some of them include:

1. Protein deficiency / hypoalbuminemia

It was initially believed that a deficiency in the consumption of protein was responsible for the development of kwashiorkor in children.

Multiple evidences have now shown that inadequate intake of dietary protein is not the primary trigger for edematous malnutrition.

2. Oxidant stress

3. Microbiome

Genetics

Protein-energy malnutrition is frequently reported in Cri du chat syndrome(CDS), a genetic disease that causes developmental delay and global growth retardation.

Associated conditions

Some of the conditions that are associated with kwashiorkor include:

Gross pathology

Post mortem examination of the liver shows the presence of fatty infiltration and necrosis which disappears with adequate treatment.[18]

Microscopic pathology

Both in kwashiorkor and marasmus hair analysis is therefore advocated as a useful diagnostic procedure for both conditions. In both cases, there is a decrease in the amount of melanin present in the scalp hair.

Kwashiorkor

Marasmus

References

  1. ↑ Cederholm T, Jägrén C, Hellström K (1995). "Outcome of protein-energy malnutrition in elderly medical patients". Am J Med. 98 (1): 67–74. doi:10.1016/S0002-9343(99)80082-5. PMID 7825621.
  2. ↑ Lerner AB (1971). "On the etiology of vitiligo and gray hair". Am J Med. 51 (2): 141–7. PMID 5095523.
  3. ↑ Saudek CD, Boulter PR, Arky RA (1973). "The natriuretic effect of glucagon and its role in starvation". J. Clin. Endocrinol. Metab. 36 (4): 761–5. doi:10.1210/jcem-36-4-761. PMID 4686383.
  4. ↑ Hedeskov CJ, Capito K (1974). "The effect of starvation on insulin secretion and glucose metabolism in mouse pancreatic islets". Biochem. J. 140 (3): 423–33. PMC 1168019. PMID 4155624.
  5. ↑ "Wiley: Metabolism at a Glance, 3rd Edition - J. G. Salway".
  6. ↑ "Pediatric Research - Mechanisms Behind Decreased Endogenous Glucose Production in Malnourished Children".
  7. ↑ Scrimshaw NS, SanGiovanni JP (1997). "Synergism of nutrition, infection, and immunity: an overview". Am. J. Clin. Nutr. 66 (2): 464S–477S. PMID 9250134.
  8. ↑ Monk JM, Makinen K, Shrum B, Woodward B (2006). "Blood corticosterone concentration reaches critical illness levels early during acute malnutrition in the weanling mouse". Exp. Biol. Med. (Maywood). 231 (3): 264–8. PMID 16514171.
  9. ↑ Auphan N, Didonato JA, Helmberg A, Rosette C, Karin M (1997). "Immunoregulatory genes and immunosuppression by glucocorticoids". Arch. Toxicol. Suppl. 19: 87–95. PMID 9079197.
  10. ↑ Coulthard MG (2015). "Oedema in kwashiorkor is caused by hypoalbuminaemia". Paediatr Int Child Health. 35 (2): 83–9. doi:10.1179/2046905514Y.0000000154. PMC 4462841. PMID 25223408.
  11. ↑ Golden MH (1998). "Oedematous malnutrition". Br Med Bull. 54 (2): 433–44. PMID 9830208.
  12. ↑ Manary MJ, Heikens GT, Golden M (2009). "Kwashiorkor: more hypothesis testing is needed to understand the aetiology of oedema". Malawi Med J. 21 (3): 106–7. PMC 3717490. PMID 20345018.
  13. ↑ Golden MH (2015). "Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium - a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia". Paediatr Int Child Health. 35 (2): 90–109. doi:10.1179/2046905515Y.0000000010. PMID 25844980.
  14. ↑ Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M (2005). "Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial". BMJ. 330 (7500): 1109. doi:10.1136/bmj.38427.404259.8F. PMC 557886. PMID 15851401.
  15. ↑ Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J; et al. (2013). "Gut microbiomes of Malawian twin pairs discordant for kwashiorkor". Science. 339 (6119): 548–54. doi:10.1126/science.1229000. PMC 3667500. PMID 23363771.
  16. ↑ Prentice AM, Nabwera H, Kwambana B, Antonio M, Moore SE (2013). "Microbes and the malnourished child". Sci Transl Med. 5 (180): 180fs11. doi:10.1126/scitranslmed.3006212. PMID 23576812.
  17. ↑ Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I; et al. (2015). "Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy". Sci Transl Med. 7 (276): 276ra24. doi:10.1126/scitranslmed.aaa4877. PMC 4423598. PMID 25717097.
  18. ↑ Lefranc, Violaine; de Luca, Arnaud; Hankard, Régis (2016). "Protein-energy malnutrition is frequent and precocious in children with cri du chat syndrome". American Journal of Medical Genetics Part A. 170 (5): 1358–1362. doi:10.1002/ajmg.a.37597. ISSN 1552-4825.

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