Perilipin-3: Difference between revisions

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== Function ==
== Function ==


[[Mannose 6-phosphate receptor]]s (MPRs) deliver [[lysosome|lysosomal]] [[hydrolase]] from the [[Golgi apparatus|Golgi]] to [[endosome]]s and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 ([[RAB9A]]), a member of the [[Ras (protein)|RAS oncogene]] family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.<ref name="Carroll_2001">{{cite journal |vauthors=Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR | title= Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. | journal = Science |volume = 292| issue = 5520 | pages = 1373–6 |date=May 2001| pmid= 11359012 | doi =  10.1126/science.1056791|  url= |  issn= }}</ref>
[[Mannose 6-phosphate receptor]]s (MPRs) deliver [[lysosome|lysosomal]] [[hydrolase]] from the [[Golgi apparatus|Golgi]] to [[endosome]]s and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 ([[RAB9A]]), a member of the [[Ras (protein)|RAS oncogene]] family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.<ref name="Carroll_2001">{{cite journal |vauthors=Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR | title= Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. | journal = Science |volume = 292| issue = 5520 | pages = 1373–6 |date=May 2001| pmid= 11359012 | doi =  10.1126/science.1056791|  url= |  issn= |bibcode=2001Sci...292.1373C}}</ref>


The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,<ref name="pmid19451273">{{cite journal |vauthors=Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S | title = TIP47 functions in the biogenesis of lipid droplets | journal = J. Cell Biol. | volume = 185 | issue = 4 | pages = 641–55 |date=May 2009 | pmid = 19451273 | doi = 10.1083/jcb.200812042 | url = | issn = | pmc = 2711566 }}</ref> despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for [[lipid]] droplets.<ref name="pmid18202123">{{cite journal |vauthors=Ducharme NA, Bickel PE | title = Lipid droplets in lipogenesis and lipolysis | journal = Endocrinology | volume = 149 | issue = 3 | pages = 942–9 |date=March 2008 | pmid = 18202123 | doi = 10.1210/en.2007-1713 | url = | issn = }}</ref>
The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,<ref name="pmid19451273">{{cite journal |vauthors=Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S | title = TIP47 functions in the biogenesis of lipid droplets | journal = J. Cell Biol. | volume = 185 | issue = 4 | pages = 641–55 |date=May 2009 | pmid = 19451273 | doi = 10.1083/jcb.200812042 | url = http://pubman.mpdl.mpg.de/pubman/item/escidoc:588093/component/escidoc:2223664/588093.pdf| issn = | pmc = 2711566 }}</ref> despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for [[lipid]] droplets.<ref name="pmid18202123">{{cite journal |vauthors=Ducharme NA, Bickel PE | title = Lipid droplets in lipogenesis and lipolysis | journal = Endocrinology | volume = 149 | issue = 3 | pages = 942–9 |date=March 2008 | pmid = 18202123 | doi = 10.1210/en.2007-1713 | url = | issn = }}</ref>


TIP47 belongs to the [[perilipin#Perilipin family of proteins|peripilin protein family]] and shares significant homology with the other genes of this family, including [[perilipin]] and [[adipose differentiation-related protein|adipophilin]].<ref name="pmid17878492">{{cite journal | author = Brasaemle DL | title = Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis | journal = J. Lipid Res. | volume = 48 | issue = 12 | pages = 2547–59 |date=December 2007 | pmid = 17878492 | doi = 10.1194/jlr.R700014-JLR200 | url = | issn = }}</ref>
TIP47 belongs to the [[perilipin#Perilipin family of proteins|peripilin protein family]] and shares significant homology with the other genes of this family, including [[perilipin]] and [[adipose differentiation-related protein|adipophilin]].<ref name="pmid17878492">{{cite journal | author = Brasaemle DL | title = Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis | journal = J. Lipid Res. | volume = 48 | issue = 12 | pages = 2547–59 |date=December 2007 | pmid = 17878492 | doi = 10.1194/jlr.R700014-JLR200 | url = http://www.jlr.org/content/48/12/2547.full.pdf| issn = }}</ref>


==Interactions==
==Interactions==
M6PRBP1 has been shown to [[Protein-protein interaction|interact]] with both [[Mannose 6-phosphate receptor]]s.<ref name=pmid9590177>{{cite journal |doi=10.1016/S0092-8674(00)81171-X |last=Díaz |first=E |authorlink= |author2=Pfeffer S R  |date=May 1998 |title=TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking |journal=Cell |volume=93 |issue=3 |pages=433–43 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 9590177 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10908666>{{cite journal |last=Orsel |first=J G |authorlink= |author2=Sincock P M |author3=Krise J P |author4=Pfeffer S R  |date=August 2000  |title=Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=16 |pages=9047–51 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10908666 |doi = 10.1073/pnas.160251397 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16819 }}</ref>
M6PRBP1 has been shown to [[Protein-protein interaction|interact]] with both [[Mannose 6-phosphate receptor]]s.<ref name=pmid9590177>{{cite journal |doi=10.1016/S0092-8674(00)81171-X |last=Díaz |first=E |authorlink= |author2=Pfeffer S R  |date=May 1998 |title=TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking |journal=Cell |volume=93 |issue=3 |pages=433–43 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 9590177 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10908666>{{cite journal |last=Orsel |first=J G |authorlink= |author2=Sincock P M |author3=Krise J P |author4=Pfeffer S R  |date=August 2000  |title=Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=16 |pages=9047–51 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10908666 |doi = 10.1073/pnas.160251397 | bibcode =2000PNAS...97.9047O | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16819 }}</ref>


== References ==
== References ==
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*{{cite journal  |vauthors=Than NG, Sumegi B, Than GN, etal |title=Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. |journal=Tumour Biol. |volume=20 |issue= 4 |pages= 184–92 |year= 1999 |pmid= 10393528 |doi=10.1159/000030062  }}
*{{cite journal  |vauthors=Than NG, Sumegi B, Than GN, etal |title=Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. |journal=Tumour Biol. |volume=20 |issue= 4 |pages= 184–92 |year= 1999 |pmid= 10393528 |doi=10.1159/000030062  }}
*{{cite journal  |vauthors=Krise JP, Sincock PM, Orsel JG, Pfeffer SR |title=Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25188–93 |year= 2000 |pmid= 10829017 |doi= 10.1074/jbc.M001138200 }}
*{{cite journal  |vauthors=Krise JP, Sincock PM, Orsel JG, Pfeffer SR |title=Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25188–93 |year= 2000 |pmid= 10829017 |doi= 10.1074/jbc.M001138200 }}
*{{cite journal  |vauthors=Orsel JG, Sincock PM, Krise JP, Pfeffer SR |title=Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9047–51 |year= 2000 |pmid= 10908666 |doi= 10.1073/pnas.160251397  | pmc=16819 }}
*{{cite journal  |vauthors=Orsel JG, Sincock PM, Krise JP, Pfeffer SR |title=Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9047–51 |year= 2000 |pmid= 10908666 |doi= 10.1073/pnas.160251397  | pmc=16819 |bibcode=2000PNAS...97.9047O }}
*{{cite journal  |vauthors=Barbero P, Buell E, Zulley S, Pfeffer SR |title=TIP47 is not a component of lipid droplets. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24348–51 |year= 2001 |pmid= 11313361 |doi= 10.1074/jbc.M102468200 }}
*{{cite journal  |vauthors=Barbero P, Buell E, Zulley S, Pfeffer SR |title=TIP47 is not a component of lipid droplets. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24348–51 |year= 2001 |pmid= 11313361 |doi= 10.1074/jbc.M102468200 }}
*{{cite journal  |vauthors=Carroll KS, Hanna J, Simon I, etal |title=Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. |journal=Science |volume=292 |issue= 5520 |pages= 1373–6 |year= 2001 |pmid= 11359012 |doi= 10.1126/science.1056791 }}
*{{cite journal  |vauthors=Carroll KS, Hanna J, Simon I, etal |title=Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. |journal=Science |volume=292 |issue= 5520 |pages= 1373–6 |year= 2001 |pmid= 11359012 |doi= 10.1126/science.1056791 |bibcode=2001Sci...292.1373C }}
*{{cite journal  |vauthors=Hanna J, Carroll K, Pfeffer SR |title=Identification of residues in TIP47 essential for Rab9 binding. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7450–4 |year= 2002 |pmid= 12032303 |doi= 10.1073/pnas.112198799  | pmc=124251 }}
*{{cite journal  |vauthors=Hanna J, Carroll K, Pfeffer SR |title=Identification of residues in TIP47 essential for Rab9 binding. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7450–4 |year= 2002 |pmid= 12032303 |doi= 10.1073/pnas.112198799  | pmc=124251 |bibcode=2002PNAS...99.7450H }}
*{{cite journal  |vauthors=Miura S, Gan JW, Brzostowski J, etal |title=Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32253–7 |year= 2002 |pmid= 12077142 |doi= 10.1074/jbc.M204410200 }}
*{{cite journal  |vauthors=Miura S, Gan JW, Brzostowski J, etal |title=Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32253–7 |year= 2002 |pmid= 12077142 |doi= 10.1074/jbc.M204410200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Sincock PM, Ganley IG, Krise JP, etal |title=Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport. |journal=Traffic |volume=4 |issue= 1 |pages= 18–25 |year= 2003 |pmid= 12535272 |doi=10.1034/j.1600-0854.2003.40104.x  }}
*{{cite journal  |vauthors=Sincock PM, Ganley IG, Krise JP, etal |title=Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport. |journal=Traffic |volume=4 |issue= 1 |pages= 18–25 |year= 2003 |pmid= 12535272 |doi=10.1034/j.1600-0854.2003.40104.x  }}
*{{cite journal  |vauthors=Than NG, Sumegi B, Bellyei S, etal |title=Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells. |journal=Eur. J. Biochem. |volume=270 |issue= 6 |pages= 1176–88 |year= 2003 |pmid= 12631276 |doi=10.1046/j.1432-1033.2003.03475.x  }}
*{{cite journal  |vauthors=Than NG, Sumegi B, Bellyei S, etal |title=Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells. |journal=Eur. J. Biochem. |volume=270 |issue= 6 |pages= 1176–88 |year= 2003 |pmid= 12631276 |doi=10.1046/j.1432-1033.2003.03475.x  }}

Latest revision as of 13:42, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene.[1] Its gene product, as well as the gene itself, is commonly known as TIP47.

Function

Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[2]

The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[3] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.[4]

TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin.[5]

Interactions

M6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors.[6][7]

References

  1. ↑ "Entrez Gene: M6PRBP1 mannose-6-phosphate receptor binding protein 1".
  2. ↑ Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6. Bibcode:2001Sci...292.1373C. doi:10.1126/science.1056791. PMID 11359012.
  3. ↑ Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S (May 2009). "TIP47 functions in the biogenesis of lipid droplets" (PDF). J. Cell Biol. 185 (4): 641–55. doi:10.1083/jcb.200812042. PMC 2711566. PMID 19451273.
  4. ↑ Ducharme NA, Bickel PE (March 2008). "Lipid droplets in lipogenesis and lipolysis". Endocrinology. 149 (3): 942–9. doi:10.1210/en.2007-1713. PMID 18202123.
  5. ↑ Brasaemle DL (December 2007). "Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis" (PDF). J. Lipid Res. 48 (12): 2547–59. doi:10.1194/jlr.R700014-JLR200. PMID 17878492.
  6. ↑ Díaz, E; Pfeffer S R (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell. UNITED STATES. 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. ISSN 0092-8674. PMID 9590177.
  7. ↑ Orsel, J G; Sincock P M; Krise J P; Pfeffer S R (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9047–51. Bibcode:2000PNAS...97.9047O. doi:10.1073/pnas.160251397. ISSN 0027-8424. PMC 16819. PMID 10908666.

Further reading

External links


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