Paget's disease of the breast medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
[[Chemotherapy]] and [[radiotherapy]] are indicated for Paget's disease of the breast as [[adjuvant therapy]] or [[Palliative care|palliative]] treatment in patients with underlying [[ductal carcinoma]] or [[invasive breast cancer]]. [[Surgery]] is the mainstay of treatment for Paget's disease of the breast. | |||
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==Medical Therapy== | ==Medical Therapy== | ||
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=== Non-operative management=== | === Non-operative management=== | ||
*The mainstay of therapies for Paget's disease of the breast are divided into 2 groups: hormonal therapy and targeted therapy.<ref name="pmid20071685">{{cite journal |vauthors=Virnig BA, Tuttle TM, Shamliyan T, Kane RL |title=Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes |journal=J. Natl. Cancer Inst. |volume=102 |issue=3 |pages=170–8 |year=2010 |pmid=20071685 |doi=10.1093/jnci/djp482 |url=}}</ref> | |||
'''Hormonal Therapy''' | |||
:*Selective estrogen receptor modulators, such as: | |||
:*[[Tamoxifen]] | |||
:*[[Raloxifene]] | |||
'''Targeted Therapy''' | |||
:*HER2-directed therapy | |||
:*[[Trastuzumab]] | |||
*The primary goal of medical therapy is to reduce the risk of ipsilateral or contralateral breast invasion and also decreases the risk of recurrence.<ref name="pmid20071685">{{cite journal |vauthors=Virnig BA, Tuttle TM, Shamliyan T, Kane RL |title=Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes |journal=J. Natl. Cancer Inst. |volume=102 |issue=3 |pages=170–8 |year=2010 |pmid=20071685 |doi=10.1093/jnci/djp482 |url=}}</ref> | |||
==References== | ==References== | ||
Revision as of 17:16, 7 February 2019
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Paget's disease of the breast Microchapters |
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Differentiating Paget's disease of the breast from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Paget's disease of the breast medical therapy On the Web |
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American Roentgen Ray Society Images of Paget's disease of the breast medical therapy |
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Directions to Hospitals Treating Paget's disease of the breast |
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Risk calculators and risk factors for Paget's disease of the breast medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Chemotherapy and radiotherapy are indicated for Paget's disease of the breast as adjuvant therapy or palliative treatment in patients with underlying ductal carcinoma or invasive breast cancer. Surgery is the mainstay of treatment for Paget's disease of the breast.
Medical Therapy
The mainstay of treatment for Paget's disease of the breast is surgery. Non-operative management is reserved for a very small proportion of patients.
Non-operative management
- The mainstay of therapies for Paget's disease of the breast are divided into 2 groups: hormonal therapy and targeted therapy.[1]
Hormonal Therapy
- Selective estrogen receptor modulators, such as:
- Tamoxifen
- Raloxifene
Targeted Therapy
- HER2-directed therapy
- Trastuzumab
- The primary goal of medical therapy is to reduce the risk of ipsilateral or contralateral breast invasion and also decreases the risk of recurrence.[1]