PLCD4: Difference between revisions

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{{Infobox_gene}}
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'''1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4''' is an [[enzyme]] that in humans is encoded by the ''PLCD4'' [[gene]].<ref name="pmid10702683">{{cite journal |vauthors=Kim H, Suh PG, Ryu SH, Park SH | title = Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 87 | issue = 3–4 | pages = 254–5 |date=Apr 2000 | pmid = 10702683 | pmc =  | doi =10.1159/000015437  }}</ref><ref name="pmid9056492">{{cite journal |vauthors=Ghosh S, Pawelczyk T, Lowenstein JM | title = Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties | journal = Protein Expr Purif | volume = 9 | issue = 2 | pages = 262–78 |date=Jun 1997 | pmid = 9056492 | pmc = | doi = 10.1006/prep.1996.0682}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLCD4 phospholipase C, delta 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84812| accessdate = }}</ref>
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==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Phospholipase C, delta 4
| HGNCid = 9062
| Symbol = PLCD4
| AltSymbols =; MGC12837
| OMIM = 605939
| ECnumber = 
| Homologene = 88782
| MGIid = 107469
| GeneAtlas_image1 = PBB_GE_PLCD4_gnf1h00905_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84812
    | Hs_Ensembl = ENSG00000115556
    | Hs_RefseqProtein = NP_116115
    | Hs_RefseqmRNA = NM_032726
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 219180866
    | Hs_GenLoc_end = 219210140
    | Hs_Uniprot = 
    | Mm_EntrezGene = 18802
    | Mm_Ensembl = ENSMUSG00000026173
    | Mm_RefseqmRNA = NM_001081456
    | Mm_RefseqProtein = NP_001074925
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 74476095
    | Mm_GenLoc_end = 74501001
    | Mm_Uniprot =
  }}
}}
'''Phospholipase C, delta 4''', also known as '''PLCD4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLCD4 phospholipase C, delta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84812| accessdate = }}</ref>


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| section_title =
| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Cefai D, Debre P, Kaczorek M, etal |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=10.1172/JCI114950  | pmc=329852 }}
| citations =
*{{cite journal   |vauthors=Zauli G, Previati M, Caramelli E, etal |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695–700 |year= 1995 |pmid= 7589147 |doi=10.1002/eji.1830250944 }}
*{{cite journal | author=Cefai D, Debre P, Kaczorek M, ''et al.'' |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117-24 |year= 1991 |pmid= 1979339 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Zauli G, Previati M, Caramelli E, ''et al.'' |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695-700 |year= 1995 |pmid= 7589147 |doi=  }}
*{{cite journal  |vauthors=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=10.1074/jbc.272.36.22385 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi=  }}
*{{cite journal   |vauthors=Mayne M, Bratanich AC, Chen P, etal |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease |journal=Neuroimmunomodulation |volume=5 |issue= 3–4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363–74 |year= 1999 |pmid= 10501179 |doi=10.1046/j.1471-4159.1999.0731363.x }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi=  }}
*{{cite journal  |vauthors=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538–42 |year= 2000 |pmid= 10843712 |doi=  10.4049/jimmunol.164.12.6538}}
*{{cite journal  | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363-74 |year= 1999 |pmid= 10501179 |doi= }}
*{{cite journal   |vauthors=Ananthanarayanan B, Das S, Rhee SG, etal |title=Membrane targeting of C2 domains of phospholipase C-delta isoforms |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3568–75 |year= 2002 |pmid= 11706040 |doi= 10.1074/jbc.M109705200 }}
*{{cite journal  | author=Kim H, Suh PG, Ryu SH, Park SH |title=Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 254-5 |year= 2000 |pmid= 10702683 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538-42 |year= 2000 |pmid= 10843712 |doi=  }}
*{{cite journal  |vauthors=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=10.1006/viro.2002.1676 }}
*{{cite journal | author=Ananthanarayanan B, Das S, Rhee SG, ''et al.'' |title=Membrane targeting of C2 domains of phospholipase C-delta isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3568-75 |year= 2002 |pmid= 11706040 |doi= 10.1074/jbc.M109705200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Lee SB, Várnai P, Balla A, etal |title=The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24362–71 |year= 2004 |pmid= 15037625 |doi= 10.1074/jbc.M312772200 }}
*{{cite journal  | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi=  }}
*{{cite journal   |vauthors=Leung DW, Tompkins C, Brewer J, etal |title=Phospholipase C δ-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells |journal=Mol. Cancer |volume=3 |issue=  |pages= 15 |year= 2004 |pmid= 15140260 |doi= 10.1186/1476-4598-3-15 | pmc=420486 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lee SB, Várnai P, Balla A, ''et al.'' |title=The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24362-71 |year= 2004 |pmid= 15037625 |doi= 10.1074/jbc.M312772200 }}
*{{cite journal   |vauthors=Chae SW, Kim JM, Yun YP, etal |title=Identification and analysis of the promoter region of the human PLC-delta4 gene |journal=Mol. Biol. Rep. |volume=34 |issue= 2 |pages= 69–77 |year= 2007 |pmid= 17394098 |doi= 10.1007/s11033-006-9014-x }}
*{{cite journal | author=Leung DW, Tompkins C, Brewer J, ''et al.'' |title=Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. |journal=Mol. Cancer |volume=3 |issue=  |pages= 15 |year= 2004 |pmid= 15140260 |doi= 10.1186/1476-4598-3-15 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Chae SW, Kim JM, Yun YP, ''et al.'' |title=Identification and analysis of the promoter region of the human PLC-delta4 gene. |journal=Mol. Biol. Rep. |volume=34 |issue= 2 |pages= 69-77 |year= 2007 |pmid= 17394098 |doi= 10.1007/s11033-006-9014-x }}
}}
{{refend}}
{{refend}}


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[[Category:EC 3.1.4]]
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Latest revision as of 18:16, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.[1][2][3]

References

  1. ↑ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization". Cytogenet Cell Genet. 87 (3–4): 254–5. doi:10.1159/000015437. PMID 10702683.
  2. ↑ Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
  3. ↑ "Entrez Gene: PLCD4 phospholipase C, delta 4".

Further reading


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