PDGFB: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Platelet-derived growth factor subunit B''' is a [[protein]] that in humans is encoded by the ''PDGFB'' [[gene]].<ref name="pmid2991848">{{cite journal | vauthors = Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F | title = Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor | journal = Nucleic Acids Res | volume = 13 | issue = 14 | pages = 5007–18 | date = Sep 1985 | pmid = 2991848 | pmc = 321845 | doi = 10.1093/nar/13.14.5007 }}</ref><ref name="pmid1661670">{{cite journal | vauthors = Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR | title = Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation | journal = EMBO J | volume = 10 | issue = 13 | pages = 4113–20 | date = Jan 1992 | pmid = 1661670 | pmc = 453161 | doi = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
 
| image = PBB_Protein_PDGFB_image.jpg
The protein encoded by this gene is a member of the [[platelet-derived growth factor]] family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha ([[PDGFA]]) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pdg.
 
| PDB = {{PDB2|1pdg}}
== Clinical significance ==
  | Name = Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
 
| HGNCid = 8800
Mutations in this gene are associated with [[meningioma]]. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for [[COL1A1]] are located, are associated with a particular type of skin tumor called [[dermatofibrosarcoma protuberans]] resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5155| accessdate = }}</ref>
| Symbol = PDGFB
| AltSymbols =; FLJ12858; PDGF2; SIS; SSV; c-sis
| OMIM = 190040
| ECnumber =
| Homologene = 74303
| MGIid = 97528
| GeneAtlas_image1 = PBB_GE_PDGFB_204200_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDGFB_216061_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PDGFB_217112_at_tn.png
| Function = {{GNF_GO|id=GO:0005161 |text = platelet-derived growth factor receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006929 |text = substrate-bound cell migration}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0030031 |text = cell projection biogenesis}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5155
    | Hs_Ensembl = ENSG00000100311
    | Hs_RefseqProtein = NP_002599
    | Hs_RefseqmRNA = NM_002608
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 37949310
    | Hs_GenLoc_end = 37971006
    | Hs_Uniprot = P01127
    | Mm_EntrezGene = 18591
    | Mm_Ensembl = ENSMUSG00000000489
    | Mm_RefseqmRNA = XM_985718
    | Mm_RefseqProtein = XP_990812
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 79823129
    | Mm_GenLoc_end = 79842063
    | Mm_Uniprot = Q549C6
  }}
}}
'''Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)''', also known as '''PDGFB''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5155| accessdate = }}</ref>
}}
==See also==
==See also==
*[[Platelet-derived growth factor]]
*[[Platelet-derived growth factor]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin}}
{{PBB_Further_reading
*{{cite journal | vauthors = Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D | title = Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment | journal = Biochem. Soc. Trans. | volume = 34 | issue = Pt 3 | pages = 454–5 | year = 2006 | pmid = 16709185 | doi = 10.1042/BST0340454 }}
| citations =
*{{cite journal | author=Kurup S, Abramsson A, Li JP, ''et al.'' |title=Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 454-5 |year= 2006 |pmid= 16709185 |doi= 10.1042/BST0340454 }}
}}
{{refend}}
{{refend}}


{{gene-22-stub}}
{{PDB Gallery|geneid=5155}}
{{Growth factors}}
{{Growth factor receptor modulators}}


[[Category:Growth factors]]
[[Category:Growth factors]]
{{WikiDoc Sources}}
 
 
{{gene-22-stub}}

Latest revision as of 00:41, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.[1][2]

Function

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha (PDGFA) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.

Clinical significance

Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.[3]

See also

References

  1. ↑ Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848.
  2. ↑ Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. 10 (13): 4113–20. PMC 453161. PMID 1661670.
  3. ↑ "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)".

Further reading

  • Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185.


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