Osteosarcoma causes: Difference between revisions

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Latest revision as of 15:56, 19 October 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

There are no established exact causes for osteosarcoma. But physicians and medical researchers suggest that the the DNA mutations (either inherited or acquired after birth) inside the bone cellular system can be responsible for the occurrence of OS.

Causes

Common Causes

Common causes of osteosarcoma may include:

There is limited understanding about the exact etiology of osteosarcoma.^[1]^[2]^[3]^[4]^[5]^[6].

The peak age during puberty seems to have an important relationship between rapid bone growth and the development and progression of OS.
Commonly osteosarcoma occur at an earlier age in girls than boys.
Osteosarcoma have also been associated with the previous history of radiation, the use of diagnostic radiocontrast agent s such as:
- Intravenous radium 224
- Thorotrast
- Exposure to alkylating agents

Less Common Causes

Less common causes of osteosarcoma include:

On the other hand, the conditions associated with an increased risk of development of osteosarcoma include:
- Paget’s disease
- Solitary or multiple osteochondroma
- Solitary enchondroma or enchondromatosis (Ollier’s disease)
- Multiple hereditary exostoses
- Fibrous dysplasia
- Chronic osteomyelitis
- Sites of bone infractions and sites of metallic implants

References

↑ Kim HJ, Chalmers PN, Morris CD (February 2010). "Pediatric osteogenic sarcoma". Curr. Opin. Pediatr. 22 (1): 61–6. doi:10.1097/MOP.0b013e328334581f. PMID 19915470.
↑ Moore DD, Luu HH (2014). "Osteosarcoma". Cancer Treat. Res. 162: 65–92. doi:10.1007/978-3-319-07323-1_4. PMID 25070231.
↑ Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M (March 2010). "Clinical presentation and imaging of bone and soft-tissue sarcomas". Cleve Clin J Med. 77 Suppl 1: S2–7. doi:10.3949/ccjm.77.s1.01. PMID 20179183.
↑ Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH (November 2010). "The prognosis for patients with osteosarcoma who have received prior manipulative therapy". J Bone Joint Surg Br. 92 (11): 1580–5. doi:10.1302/0301-620X.92B11.24706. PMID 21037356.
↑ Ma C, Han J, Dong D, Wang N (June 2018). "MicroRNA-152 Suppresses Human Osteosarcoma Cell Proliferation and Invasion by Targeting E2F Transcription Factor 3". Oncol. Res. 26 (5): 765–773. doi:10.3727/096504017X15021536183535. PMID 28810933.
↑ Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M (July 2018). "The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients". BMC Med. Genet. 19 (1): 112. doi:10.1186/s12881-018-0627-4. PMC 6035436. PMID 29980176.

Template:WH Template:WS

[pmid19915470-1] Kim HJ, Chalmers PN, Morris CD (February 2010). "Pediatric osteogenic sarcoma". Curr. Opin. Pediatr. 22 (1): 61–6. doi:10.1097/MOP.0b013e328334581f. PMID 19915470.

[pmid25070231-2] Moore DD, Luu HH (2014). "Osteosarcoma". Cancer Treat. Res. 162: 65–92. doi:10.1007/978-3-319-07323-1_4. PMID 25070231.

[pmid20179183-3] Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M (March 2010). "Clinical presentation and imaging of bone and soft-tissue sarcomas". Cleve Clin J Med. 77 Suppl 1: S2–7. doi:10.3949/ccjm.77.s1.01. PMID 20179183.

[pmid21037356-4] Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH (November 2010). "The prognosis for patients with osteosarcoma who have received prior manipulative therapy". J Bone Joint Surg Br. 92 (11): 1580–5. doi:10.1302/0301-620X.92B11.24706. PMID 21037356.

[pmid28810933-5] Ma C, Han J, Dong D, Wang N (June 2018). "MicroRNA-152 Suppresses Human Osteosarcoma Cell Proliferation and Invasion by Targeting E2F Transcription Factor 3". Oncol. Res. 26 (5): 765–773. doi:10.3727/096504017X15021536183535. PMID 28810933.

[pmid29980176-6] Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M (July 2018). "The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients". BMC Med. Genet. 19 (1): 112. doi:10.1186/s12881-018-0627-4. PMC 6035436. PMID 29980176.

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[6]

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{CMG}}
+{{CMG}}; {{AE}}[[User:DrMars|Mohammadmain Rezazadehsaatlou[2]]].
 {{Osteosarcoma}}
 ==Overview==
-==Causes==
+There are no established exact causes for [[osteosarcoma]]. But physicians and medical researchers suggest that the the [[DNA mutations]] (either [[inherited]] or [[acquired]] after birth) inside the [[bone]] cellular system can be responsible for the occurrence of [[Osteosarcoma|OS]].
-The causes of osteosarcoma are not known. Questions remain about whether [[radium]], or [[fluoride]], in drinking water can act as "environmental triggers" for increasing the incidence of the disease.
-A low [[selenium]] or [[Vitamin D|Vitamin D3]] level or a high level of [[inflammation]], as measured by interleukin-6, interleukin-8, or Nf-kB, Tumor Necrosis Factor Alpha may have a significant role as tumor suppressors and tumor initiators respectively.
+== Causes ==
-Recent studies show that an increased level of c-Fos can lead to osteosarcoma. The study that showed this result was done on transgenic mice in which the Fluid Sheer Stress (FSS) was increased to increase the number of osteoblast. Since c-Fos is ubiquitous in its overexpression it can not only increase the osteoblast resulting in the symptoms osteosarcoma. Therefore it is recently believed that a biological effect that may cause osteosarcoma is an error in the molecular pathway that controls c-Fos, causing an overexpression with no other counter stimuli to stop over production.
+=== Common Causes ===
+Common causes of [[osteosarcoma]] may include:
+* There is limited understanding about the exact etiology of [[osteosarcoma]].<ref name="pmid19915470">{{cite journal |vauthors=Kim HJ, Chalmers PN, Morris CD |title=Pediatric osteogenic sarcoma |journal=Curr. Opin. Pediatr. |volume=22 |issue=1 |pages=61–6 |date=February 2010 |pmid=19915470 |doi=10.1097/MOP.0b013e328334581f |url=}}</ref><ref name="pmid25070231">{{cite journal |vauthors=Moore DD, Luu HH |title=Osteosarcoma |journal=Cancer Treat. Res. |volume=162 |issue= |pages=65–92 |date=2014 |pmid=25070231 |doi=10.1007/978-3-319-07323-1_4 |url=}}</ref><ref name="pmid20179183">{{cite journal |vauthors=Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M |title=Clinical presentation and imaging of bone and soft-tissue sarcomas |journal=Cleve Clin J Med |volume=77 Suppl 1 |issue= |pages=S2–7 |date=March 2010 |pmid=20179183 |doi=10.3949/ccjm.77.s1.01 |url=}}</ref><ref name="pmid21037356">{{cite journal |vauthors=Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH |title=The prognosis for patients with osteosarcoma who have received prior manipulative therapy |journal=J Bone Joint Surg Br |volume=92 |issue=11 |pages=1580–5 |date=November 2010 |pmid=21037356 |doi=10.1302/0301-620X.92B11.24706 |url=}}</ref><ref name="pmid28810933">{{cite journal |vauthors=Ma C, Han J, Dong D, Wang N |title=MicroRNA-152 Suppresses Human Osteosarcoma Cell Proliferation and Invasion by Targeting E2F Transcription Factor 3 |journal=Oncol. Res. |volume=26 |issue=5 |pages=765–773 |date=June 2018 |pmid=28810933 |doi=10.3727/096504017X15021536183535 |url=}}</ref><ref name="pmid29980176">{{cite journal |vauthors=Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M |title=The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients |journal=BMC Med. Genet. |volume=19 |issue=1 |pages=112 |date=July 2018 |pmid=29980176 |pmc=6035436 |doi=10.1186/s12881-018-0627-4 |url=}}</ref>.
-===Drugs===
+* The peak age during [[puberty]] seems to have an important relationship between rapid bone growth and the development and progression of [[Osteosarcoma|OS]].
-*[[Pergolide]]
+* Commonly [[osteosarcoma]] occur at an earlier age in girls than boys.
+*[[Osteosarcoma]] have also been associated with the previous history of [[radiation]], the use of diagnostic [[radiocontrast]] agent s such as:
+**[[Intravenous]] [[radium]] 224
+**[[Thorotrast]]
+** Exposure to [[Alkylating agent|alkylating agents]]
+=== Less Common Causes ===
+Less common causes of [[osteosarcoma]] include:
+* On the other hand, the conditions associated with an increased risk of development of [[osteosarcoma]] include:
+**[[Paget’s disease]]
+**[[Solitary]] or multiple [[osteochondroma]]
+**[[Solitary]] [[enchondroma]] or [[Enchondroma|enchondromatosis]] ([[Ollier disease|Ollier’s disease]])
+** Multiple [[Heredity|hereditary]] [[exostoses]]
+**[[Fibrous dysplasia]]
+** Chronic [[osteomyelitis]]
+** Sites of [[bone]] infractions and sites of metallic [[implants]]
 ==References==
@@ Line 23: / Line 40: @@
 [[Category:Orthopedics]]
 [[Category:Mature chapter]]
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Orthopedics]]