Optic nerve glioma classification: Difference between revisions

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==Overview==
==Overview==
Optic nerve gliomas may be classified into two subtypes based on anatomic location, and whether or not they are associated with neurofibromatosis type 1. Optic nerve gliomas may be classified according to anatomic location into two subtypes: anterior tumors and posterior tumors.
Optic nerve glioma may be classified into several subtypes based on [[microscopic]] [[histopathology]], anatomic location, and association with [[neurofibromatosis]] type 1. Optic pathway gliomas are classified according to WHO classification into two subtypes: [[pilocytic astrocytoma]] and fibrillary astrocytoma. Optic nerve gliomas may be classified according to anatomic location into two subtypes: anterior visual pathway tumors and posterior visual pathway [[tumors]]. Based on whether or not they are associated with [[neurofibromatosis type 1]], they may be classified into two subtypes: optic nerve gliomas associated with [[neurofibromatosis type 1]] and optic nerve gliomas not associated with [[neurofibromatosis type 1]].
 
==Classification==
==Classification==
Optic nerve gliomas may be classified into several subtypes based on anatomic location, and whether or not they are associated with neurofibromatosis type 1. Optic nerve gliomas may be classified according to anatomic location into two subtypes: anterior tumors and posterior tumors.
*Optic nerve glioma may be classified into several subtypes based on [[microscopic]] [[histopathology]], anatomic location, and association with neurofibromatosis type 1.
According to their location along the optic pathway, the two major categories are:
 
 
{| class="wikitable"
|+
! colspan="2" |Classifications of Optic Nerve Glioma
|-
| rowspan="2" |Microscopic Histopathology
|Fibrillary astrocytoma(40%)
|-
|[[Pilocytic astrocytoma]](60%)
|-
| rowspan="2" |Association with Neurofibromatosis type 1
|Optic nerve gliomas associated with [[neurofibromatosis type 1]]
|-
|Optic nerve gliomas not associated with [[neurofibromatosis type 1]]
|-
| rowspan="2" |Anatomic location
|Anterior visual pathway
 
*Orbital
*Intracanalicular
*Intracranial prechiasmal lesions.
|-
|Posterior visual pathway
 
*[[Optic chiasm]]
*[[Hypothalamus]]
*Anterior third [[ventricle]]
|}
 
==Classification based on Microscopic Histopathology==
 
*Optic pathway gliomas are classified according to WHO classification into two subtypes:
 
:*[[Pilocytic astrocytoma]](60%)
 
:*Fibrillary astrocytoma(40%)
==Classification based on Association with Neurofibromatosis type 1==
*Based on whether or not they are associated with [[neurofibromatosis type 1]], they may be classified into two subtypes:  
 
:*Optic nerve gliomas associated with [[neurofibromatosis type 1]]
 
:*Optic nerve gliomas not associated with [[neurofibromatosis type 1]]
[[Neurofibromatosis type 1]] tumors are more likely to involve anterior visual pathway. Optic nerve gliomas without an association with neurofibromatosis type 1 are more frequent in the posterior visual pathway.<ref name="pmid18796556">{{cite journal| author=Taylor T, Jaspan T, Milano G, Gregson R, Parker T, Ritzmann T et al.| title=Radiological classification of optic pathway gliomas: experience of a modified functional classification system. | journal=Br J Radiol | year= 2008 | volume= 81 | issue= 970 | pages= 761-6 | pmid=18796556 | doi=10.1259/bjr/65246351 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18796556  }} </ref>  In children diagnosed with NF-1, approximately 15% develop optic gliomas.<ref name="pmid9029062">{{cite journal| author=Listernick R, Louis DN, Packer RJ, Gutmann DH| title=Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force. | journal=Ann Neurol | year= 1997 | volume= 41 | issue= 2 | pages= 143-9 | pmid=9029062 | doi=10.1002/ana.410410204 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9029062  }} </ref> <ref name="pmid8021787">{{cite journal| author=Listernick R, Charrow J, Greenwald M, Mets M| title=Natural history of optic pathway tumors in children with neurofibromatosis type 1: a longitudinal study. | journal=J Pediatr | year= 1994 | volume= 125 | issue= 1 | pages= 63-6 | pmid=8021787 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8021787  }} </ref>  Twenty to forty percent of optic gliomas occur in children with NF-1.
 
==Classification based on Anatomic location==
*According to their location along the optic pathway, the two major categories are:
===Anterior visual pathway===  
===Anterior visual pathway===  
*Orbital
*Orbital
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Most of anterior visual pathway tumors are classified as pilocytic astrocytomas and they occur most frequently in prepubertal children.<ref name="pmid7108594">{{cite journal| author=Tenny RT, Laws ER, Younge BR, Rush JA| title=The neurosurgical management of optic glioma. Results in 104 patients. | journal=J Neurosurg | year= 1982 | volume= 57 | issue= 4 | pages= 452-8 | pmid=7108594 | doi=10.3171/jns.1982.57.4.0452 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7108594  }} </ref>  
Most of anterior visual pathway tumors are classified as pilocytic astrocytomas and they occur most frequently in prepubertal children.<ref name="pmid7108594">{{cite journal| author=Tenny RT, Laws ER, Younge BR, Rush JA| title=The neurosurgical management of optic glioma. Results in 104 patients. | journal=J Neurosurg | year= 1982 | volume= 57 | issue= 4 | pages= 452-8 | pmid=7108594 | doi=10.3171/jns.1982.57.4.0452 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7108594  }} </ref>  
===Posterior visual pathway===  
===Posterior visual pathway===  
*Optic chiasm
*[[Optic chiasm]]
*Hypothalamus
*[[Hypothalamus]]
*Anterior third ventricle  
*Anterior third [[ventricle]]
Most of posterior visual pathway tumors are classified histologically as pilocytic astrocytomas, and occasionally gangliogliomas. Hypothalamic and chiasmal lesions present at a mean age of about three years.<ref name="pmid2340532">{{cite journal| author=Benes V, Julisová I, Julis I| title=Our treatment philosophy of gliomas of the anterior visual pathways. | journal=Childs Nerv Syst | year= 1990 | volume= 6 | issue= 2 | pages= 75-8 | pmid=2340532 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2340532  }} </ref>  
 
About 10% of optic pathway tumors are located within an optic nerve, one third of the tumors involve both optic nerve and chiasm, another one third involves predominantly the chiasm itself, and one fourth involves predominantly the hypothalamus. 5 5% of optic nerve gliomas are multicentric.
<br />
===Association with NF1===
 
Neurofibromatosis type 1 tumors are more likely to involve anterior visual pathway. Optic nerve gliomas without an association with neurofibromatosis type 1 are more frequent in the posterior visual pathway.<ref name="pmid18796556">{{cite journal| author=Taylor T, Jaspan T, Milano G, Gregson R, Parker T, Ritzmann T et al.| title=Radiological classification of optic pathway gliomas: experience of a modified functional classification system. | journal=Br J Radiol | year= 2008 | volume= 81 | issue= 970 | pages= 761-6 | pmid=18796556 | doi=10.1259/bjr/65246351 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18796556  }} </ref> NF-1 is an autosomal dominant disorder with an incidence of one in 3000-5000 births. In children diagnosed with NF-1, approximately 15% develop optic gliomas.<ref name="pmid9029062">{{cite journal| author=Listernick R, Louis DN, Packer RJ, Gutmann DH| title=Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force. | journal=Ann Neurol | year= 1997 | volume= 41 | issue= 2 | pages= 143-9 | pmid=9029062 | doi=10.1002/ana.410410204 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9029062  }} </ref> <ref name="pmid8021787">{{cite journal| author=Listernick R, Charrow J, Greenwald M, Mets M| title=Natural history of optic pathway tumors in children with neurofibromatosis type 1: a longitudinal study. | journal=J Pediatr | year= 1994 | volume= 125 | issue= 1 | pages= 63-6 | pmid=8021787 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8021787  }} </ref>  Twenty to forty percent of optic gliomas occur in children with NF-1.
* Most of posterior visual pathway tumors are classified histologically as [[pilocytic astrocytomas]], and occasionally gangliogliomas.
* [[Hypothalamic]] and chiasmal lesions present at a mean age of about three years.<ref name="pmid2340532">{{cite journal| author=Benes V, Julisová I, Julis I| title=Our treatment philosophy of gliomas of the anterior visual pathways. | journal=Childs Nerv Syst | year= 1990 | volume= 6 | issue= 2 | pages= 75-8 | pmid=2340532 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2340532  }} </ref>  
 
* About 10% of optic pathway tumors are located within an optic nerve, one third of the tumors involve both [[optic nerve]] and chiasm, another one third involves predominantly the chiasm itself, and one fourth involves predominantly the hypothalamus. 5 5% of optic nerve gliomas are multicentric.


==References==
==References==
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[[Category:Up-To-Date]]
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[[Category:Neurosurgery]]

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Optic nerve glioma may be classified into several subtypes based on microscopic histopathology, anatomic location, and association with neurofibromatosis type 1. Optic pathway gliomas are classified according to WHO classification into two subtypes: pilocytic astrocytoma and fibrillary astrocytoma. Optic nerve gliomas may be classified according to anatomic location into two subtypes: anterior visual pathway tumors and posterior visual pathway tumors. Based on whether or not they are associated with neurofibromatosis type 1, they may be classified into two subtypes: optic nerve gliomas associated with neurofibromatosis type 1 and optic nerve gliomas not associated with neurofibromatosis type 1.

Classification

  • Optic nerve glioma may be classified into several subtypes based on microscopic histopathology, anatomic location, and association with neurofibromatosis type 1.


Classifications of Optic Nerve Glioma
Microscopic Histopathology Fibrillary astrocytoma(40%)
Pilocytic astrocytoma(60%)
Association with Neurofibromatosis type 1 Optic nerve gliomas associated with neurofibromatosis type 1
Optic nerve gliomas not associated with neurofibromatosis type 1
Anatomic location Anterior visual pathway
  • Orbital
  • Intracanalicular
  • Intracranial prechiasmal lesions.
Posterior visual pathway

Classification based on Microscopic Histopathology

  • Optic pathway gliomas are classified according to WHO classification into two subtypes:
  • Fibrillary astrocytoma(40%)

Classification based on Association with Neurofibromatosis type 1

Neurofibromatosis type 1 tumors are more likely to involve anterior visual pathway. Optic nerve gliomas without an association with neurofibromatosis type 1 are more frequent in the posterior visual pathway.[1] In children diagnosed with NF-1, approximately 15% develop optic gliomas.[2] [3] Twenty to forty percent of optic gliomas occur in children with NF-1.

Classification based on Anatomic location

  • According to their location along the optic pathway, the two major categories are:

Anterior visual pathway

  • Orbital
  • Intracanalicular
  • Intracranial prechiasmal lesions.

Most of anterior visual pathway tumors are classified as pilocytic astrocytomas and they occur most frequently in prepubertal children.[4]

Posterior visual pathway


  • Most of posterior visual pathway tumors are classified histologically as pilocytic astrocytomas, and occasionally gangliogliomas.
  • Hypothalamic and chiasmal lesions present at a mean age of about three years.[5]
  • About 10% of optic pathway tumors are located within an optic nerve, one third of the tumors involve both optic nerve and chiasm, another one third involves predominantly the chiasm itself, and one fourth involves predominantly the hypothalamus. 5 5% of optic nerve gliomas are multicentric.

References

  1. ↑ Taylor T, Jaspan T, Milano G, Gregson R, Parker T, Ritzmann T; et al. (2008). "Radiological classification of optic pathway gliomas: experience of a modified functional classification system". Br J Radiol. 81 (970): 761–6. doi:10.1259/bjr/65246351. PMID 18796556.
  2. ↑ Listernick R, Louis DN, Packer RJ, Gutmann DH (1997). "Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force". Ann Neurol. 41 (2): 143–9. doi:10.1002/ana.410410204. PMID 9029062.
  3. ↑ Listernick R, Charrow J, Greenwald M, Mets M (1994). "Natural history of optic pathway tumors in children with neurofibromatosis type 1: a longitudinal study". J Pediatr. 125 (1): 63–6. PMID 8021787.
  4. ↑ Tenny RT, Laws ER, Younge BR, Rush JA (1982). "The neurosurgical management of optic glioma. Results in 104 patients". J Neurosurg. 57 (4): 452–8. doi:10.3171/jns.1982.57.4.0452. PMID 7108594.
  5. ↑ Benes V, Julisová I, Julis I (1990). "Our treatment philosophy of gliomas of the anterior visual pathways". Childs Nerv Syst. 6 (2): 75–8. PMID 2340532.

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